Componenti

1. Iagnocco Annamaria (Coordinatore)

Contatti

• annamaria.iagnocco@unito.it
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Settore ERC

Attività

Research main topics

Research Group - Principal Investigator: Prof. Annamaria Iagnocco DSCB, Rheumatology Unit Research Activity

The research activity of the Rheumatology Research Group at DSCB led by Professor Annamaria Iagnocco is focused on a broad spectrum of rheumatic diseases, particularly including inflammatory arthropathies and chronic autoimmune diseases. During her career, Professor Iagnocco directed her research mainly on the validation of tools for the diagnosis and clinical monitoring of various autoimmune diseases (i.e. rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis and Sjögren's syndrome) as well as spondyloarthritis, crystal-related arthropathies and osteoarthritis. 

Professor Iagnocco and her research group conducted international studies on the application of several diagnostic methods and the use of innovative ultrasonographic tools (i.e. elastography, three-dimensional ultrasonography, fusion imaging, automated radiofrequency ultrasound) in rheumatic and musculoskeletal diseases.   Importantly, the results obtained from randomized controlled trials and longitudinal multicentre studies were used to validate international guidelines for the evaluation of the therapeutic response in different autoimmune and inflammatory rheumatic diseases. 

Professor Iagnocco is Member of the Presidency of EULAR (European Alliance of Associations for Rheumatology) as Active Past President, Board Member of EULAR, Chair of the Ultrasound Study Group of the Italian Society of Rheumatology, Chair of the North Italian Network, member of several working groups on ultrasound and imaging in rheumatic and musculoskeletal diseases. Moreover, the coordination and direction of national and international research groups and committees, including the OMERACT (Outcome Measures in Rheumatology Clinical Trials) international study group on Clinical Trials, supported her research activity and the investigations of her research group. 

More recently, the Rheumatology Research Group activities at DSCB are mainly focused on the analysis of the inflammatory status in patients with COVID-19 and rheumatic diseases, on the pathogenesis and diagnostics of arthritis and of connective tissue diseases. Moreover, the Research Group is involved in several multicentric studies and national and international clinical trials on new molecules addressing the inflammatory aspects of rheumatic and musculoskeletal diseases. 

Current Research Projects

• Several observational studies evaluating the effects and safety of biotechnological drugs in rheumatic and musculoskeletal diseases (mostly spondyloarthritis, rheumatoid arthritis, systemic lupus erythematosus);
• Studies aimed to develop the classification criteria of calcium pyrophosphate deposition disease and to evaluate the role of ultrasound imaging in the differential diagnosis of inflammatory arthropathies;
• Investigations on the involvement and the severity of SARS-Cov 2 infection in patients with rheumatic and musculoskeletal diseases.

Prodotti della ricerca

Pubblicazioni/Publications

1. Novel and reliable DACTylitis glObal Sonographic (DACTOS) score in psoriatic arthritis. Zabotti A, Sakellariou G, Tinazzi I, Idolazzi L, Batticciotto A, Canzoni M, Carrara G, De Lucia O, Figus F, Girolimetto N, Macchioni P, McConnell R, Possemato N, Iagnocco A. Ann Rheum Dis. 2020;79:1037-43
2. The predictive role of ultrasound-detected tenosynovitis and joint synovitis for flare in patients with rheumatoid arthritis in stable remission. Results of an Italian multicentre study of the Italian Society for Rheumatology Group for Ultrasound: the STARTER study. Filippou G, Sakellariou G, Scirè CA, Carrara G, Rumi F, Bellis E, Adinolfi A, Batticciotto A, Bortoluzzi A, Cagnotto G, Caprioli M, Canzoni M, Cavatorta FP, De Lucia O, Di Sabatino V, Draghessi A, Farina I, Focherini MC, Gabba A, Gutierrez M, Idolazzi L, Luccioli F, Macchioni Pi, Massarotti MS, Mastaglio C, Menza L, Muratore M, Parisi S, Picerno V, Piga M, Ramonda R, Raffeiner B, Rossi D, Rossi S, Rossini P, Scioscia C, Venditti C, Volpe A, Iagnocco A. Ann Rheum Dis 2018; 77:1283-89
3. Identification of calcium pyrophosphate deposition disease (CPPD) by ultrasound: reliability of the OMERACT definitions in an extended set of joints-an international multiobserver study by the OMERACT Calcium Pyrophosphate Deposition Disease Ultrasound Subtask Force. Filippou G, Scirè CA, Adinolfi A, Damjanov NS, Carrara G, Bruyn GAW, Cazenave T, D'Agostino MA, Delle Sedie A, Di Sabatino V, Diaz Cortes ME, Filippucci E, Gandjbakhch F, Gutierrez M, Maccarter DK, Micu M, Möller Parera I, Mouterde G, Mortada MA, Naredo E, Pineda C, Porta F, Reginato AM, Satulu I,  Schmidt WA, Serban T, Terslev L, Vlad V, Vreju FA, Zufferey P, Bozios P, Toscano C, Picerno V, Iagnocco Ann Rheum Dis 2018; 77:1194-1199
4. EULAR recommendations for the use of imaging in the clinical management of peripheral joint osteoarthritis. Sakellariou G, Conaghan PG, Zhang W,  Bijlsma JWJ, Boyesen P, D'Agostino MA, Doherty M, Fodor D,  Kloppenburg M, Miese F, Naredo E, Porcheret M, Iagnocco A. Ann Rheum Dis 2017;76:1484-94
5. An OMERACT reliability exercise of inflammatory and structural abnormalities in patients with knee osteoarthritis using ultrasound assessment. AW Bruyn G, Naredo E, Damjanov N, Bachta A, Baudoin P, Hammer HB, Lamers-Karnebeek FBg, Moller Parera I, Richards B, Taylor M, Ben-Artzi A, D'Agostino MA, Garrido J, Iagnocco Ann Rheum Dis 2016; 75:842-6