Nutrition, reactive metabolites and bioactive compounds in metabolic inflammation
Nutrition, reactive metabolites and bioactive compounds in metabolic inflammation
Componenti
- Mastrocola Raffaella (Coordinatore)
Contatti
Settore ERC
Attività
Dal 2010 attraverso i nostri studi stiamo approfondendo il ruolo patogenetico degli AGEs endogeni, che si producono in conseguenza di diete ricche in acidi grassi saturi o zuccheri, ed esogeni, cioè assunti con gli alimenti, nell’insorgenza di patologie metaboliche, infiammatorie croniche e degenerative. Nelle nostre più recenti pubblicazioni abbiamo dimostrato che l’accumulo di AGEs in vari tessuti interferisce con diverse vie di segnale intracellulari coinvolte nello sviluppo di insulino resistenza, steatoepatite, cachessia diabetica e malattie neurodegenerative, nonché sulla composizione del microbiota, interferendo sull’immunodulazione e inducendo una condizione proinfiammatoria. L’utilizzo di prodotti inibitori della formazione di AGEs, come la piridossamina, ci sta consentendo di osservare numerosi benefici, indicando gli AGEs come nuovi obiettivi terapeutici per la prevenzione di tali patologie.
In stretta collaborazione con il laboratorio diretto dal Prof. Schalkwijk all’Università di Maastricht abbiamo condotto un progetto finalizzato allo studio delle alterazioni del metabolismo sfingolipidico indotte dagli AGEs e dal loro recettore RAGE su modelli in vitro e in topi geneticamente modificati, permettondo di ampliare l'ambito di conoscenze sui meccanismi patogenetici attivati dall'asse AGE/RAGE.
Attualmente sono in corso protocolli sperimentali per valutare l’efficacia dell’inibizione farmacologica di RAGE nella prevenzione delle alterazioni del metabolismo sfingolipidico e del microbiota intestinale e dei conseguenti disordini metabolici e infiammatori.
Prodotti della ricerca
Collino M, Benetti E, Rogazzo M, Mastrocola R, Yaqoob MM, Aragno M, Theimermann C, Fantozzi R. (2024) Corrigendum to "Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR-delta agonism correlates with impaired NLRP3 inflammasome activation'' [Biochem. Pharmacol. 85(2) (2013) 257-264]. Biochemical pharmacology 222 116060 [DOI PMID]
Aimaretti E, Porchietto E, Mantegazza G, Gargari G, Collotta D, Einaudi G, Ferreira Alves G, Marzani E, Algeri A, Dal Bello F, Aragno M, Cifani C, Guglielmetti S, Mastrocola R, Collino M. (2024) Anti-Glycation Properties of Zinc-Enriched Arthrospira platensis (Spirulina) Contribute to Prevention of Metaflammation in a Diet-Induced Obese Mouse Model. Nutrients 16(4) [DOI PMID]
Fornelli C, Sofia Cento A, Nevi L, Mastrocola R, Ferreira Alves G, Caretti G, Collino M, Penna F. (2024) The BET inhibitor JQ1 targets fat metabolism and counteracts obesity. Journal of advanced research [DOI PMID]
Almasri F, Collotta D, Aimaretti E, Sus N, Aragno M, Dal Bello F, Eva C, Mastrocola R, Landberg R, Frank J, Collino M. (2024) Dietary Intake of Fructooligosaccharides Protects against Metabolic Derangements Evoked by Chronic Exposure to Fructose or Galactose in Rats. Molecular nutrition & food research 68(4) e2300476 [DOI PMID]
Kar S, Perrelli A, Bali KK, Mastrocola R, Kar A, Khan B, Gand L, Nayak A, Hartmann C, Kunz WS, Samii A, Bertalanffy H, Retta SF. (2024) Identification of galectin-3 as a novel potential prognostic/predictive biomarker and therapeutic target for cerebral cavernous malformation disease. Genes & diseases 11(1) 67-71 [DOI PMID]
Mastrocola R, Aimaretti E, Ferreira Alves G, Cento AS, Fornelli C, Dal Bello F, Ferraris C, Goitre L, Perrelli A, Retta SF. (2022) Heterozygous Loss of KRIT1 in Mice Affects Metabolic Functions of the Liver, Promoting Hepatic Oxidative and Glycative Stress. International journal of molecular sciences 23(19) [DOI PMID]
Wouters K, Cento AS, Gaens KH, Teunissen M, Scheijen JLJM, Barutta F, Chiazza F, Collotta D, Aragno M, Gruden G, Collino M, Schalkwijk CG, Mastrocola R. (2021) Deletion of RAGE fails to prevent hepatosteatosis in obese mice due to impairment of other AGEs receptors and detoxifying systems. Scientific reports 11(1) 17373 [DOI PMID]
Mastrocola R, Dal Bello F, Cento AS, Gaens K, Collotta D, Aragno M, Medana C, Collino M, Wouters K, Schalkwijk CG. (2021) Altered hepatic sphingolipid metabolism in insulin resistant mice: Role of advanced glycation endproducts. Free radical biology & medicine 169 425-435 [DOI PMID]
Mastrocola R, Collotta D, Gaudioso G, Le Berre M, Cento AS, Ferreira Alves G, Chiazza F, Verta R, Bertocchi I, Manig F, Hellwig M, Fava F, Cifani C, Aragno M, Henle T, Joshi L, Tuohy K, Collino M. (2020) Effects of Exogenous Dietary Advanced Glycation End Products on the Cross-Talk Mechanisms Linking Microbiota to Metabolic Inflammation. Nutrients 12(9) [DOI PMID]
Collotta D, Hull W, Mastrocola R, Chiazza F, Cento AS, Murphy C, Verta R, Alves GF, Gaudioso G, Fava F, Yaqoob M, Aragno M, Tuohy K, Thiemermann C, Collino M. (2020) Baricitinib counteracts metaflammation, thus protecting against diet-induced metabolic abnormalities in mice. Molecular metabolism 39 101009 [DOI PMID]
Felicetti F, Cento AS, Fornengo P, Cassader M, Mastrocola R, D'Ascenzo F, Settanni F, Benso A, Arvat E, Collino M, Fagioli F, Aragno M, Brignardello E. (2020) Advanced glycation end products and chronic inflammation in adult survivors of childhood leukemia treated with hematopoietic stem cell transplantation. Pediatric blood & cancer 67(3) e28106 [DOI PMID]
Vieceli Dalla Sega F, Mastrocola R, Aquila G, Fortini F, Fornelli C, Zotta A, Cento AS, Perrelli A, Boda E, Pannuti A, Marchi S, Pinton P, Ferrari R, Rizzo P, Retta SF. (2019) KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction. International journal of molecular sciences 20(19) [DOI PMID]
Purvis GSD, Collino M, Loiola RA, Baragetti A, Chiazza F, Brovelli M, Sheikh MH, Collotta D, Cento A, Mastrocola R, Aragno M, Cutrin JC, Reutelingsperger C, Grigore L, Catapano AL, Yaqoob MM, Norata GD, Solito E, Thiemermann C. (2019) Identification of AnnexinA1 as an Endogenous Regulator of RhoA, and Its Role in the Pathophysiology and Experimental Therapy of Type-2 Diabetes. Frontiers in immunology 10 571 [DOI PMID]
Barutta F, Bellini S, Mastrocola R, Gambino R, Piscitelli F, di Marzo V, Corbetta B, Vemuri VK, Makriyannis A, Annaratone L, Bruno G, Gruden G. (2018) Reversal of albuminuria by combined AM6545 and perindopril therapy in experimental diabetic nephropathy. British journal of pharmacology 175(23) 4371-4385 [DOI PMID]
Barutta F, Bellini S, Mastrocola R, Bruno G, Gruden G. (2018) MicroRNA and Microvascular Complications of Diabetes. International journal of endocrinology 2018 6890501 [DOI PMID]
Barutta F, Bruno G, Mastrocola R, Bellini S, Gruden G. (2018) The role of cannabinoid signaling in acute and chronic kidney diseases. Kidney international 94(2) 252-258 [DOI PMID]
Mastrocola R, Ferrocino I, Liberto E, Chiazza F, Cento AS, Collotta D, Querio G, Nigro D, Bitonto V, Cutrin JC, Rantsiou K, Durante M, Masini E, Aragno M, Cordero C, Cocolin L, Collino M. (2018) Fructose liquid and solid formulations differently affect gut integrity, microbiota composition and related liver toxicity: a comparative in vivo study. The Journal of nutritional biochemistry 55 185-199 [DOI PMID]
Bressanello D, Liberto E, Collino M, Chiazza F, Mastrocola R, Reichenbach SE, Bicchi C, Cordero C. (2018) Combined untargeted and targeted fingerprinting by comprehensive two-dimensional gas chromatography: revealing fructose-induced changes in mice urinary metabolic signatures. Analytical and bioanalytical chemistry 410(11) 2723-2737 [DOI PMID]
Barutta F, Mastrocola R, Bellini S, Bruno G, Gruden G. (2018) Cannabinoid Receptors in Diabetic Kidney Disease. Current diabetes reports 18(2) 9 [DOI PMID]
Benetti E, Mastrocola R, Chiazza F, Nigro D, D'Antona G, Bordano V, Fantozzi R, Aragno M, Collino M, Minetto MA. (2018) Effects of vitamin D on insulin resistance and myosteatosis in diet-induced obese mice. PloS one 13(1) e0189707 [DOI PMID]
Bellini S, Barutta F, Mastrocola R, Imperatore L, Bruno G, Gruden G. (2017) Heat Shock Proteins in Vascular Diabetic Complications: Review and Future Perspective. International journal of molecular sciences 18(12) [DOI PMID]
Chiazza F, Cento AS, Collotta D, Nigro D, Rosa G, Baratta F, Bitonto V, Cutrin JC, Aragno M, Mastrocola R, Collino M. (2017) Protective Effects of Pyridoxamine Supplementation in the Early Stages of Diet-Induced Kidney Dysfunction. BioMed research international 2017 2682861 [DOI PMID]
Spallotta F, Cencioni C, Atlante S, Garella D, Cocco M, Mori M, Mastrocola R, Kuenne C, Guenther S, Nanni S, Azzimato V, Zukunft S, Kornberger A, Surun D, Schnutgen F, von Melchner H, Di Stilo A, Aragno M, Braspenning M, van Criekinge W, De Blasio MJ, Ritchie RH, Zaccagnini G, Martelli F, Farsetti A, Fleming I, Braun T, Beiras-Fernandez A, Botta B, Collino M, Bertinaria M, Zeiher AM, Gaetano C. (2018) Stable Oxidative Cytosine Modifications Accumulate in Cardiac Mesenchymal Cells From Type2 Diabetes Patients: Rescue by alpha-Ketoglutarate and TET-TDG Functional Reactivation. Circulation research 122(1) 31-46 [DOI PMID]
Aragno M, Mastrocola R. (2017) Dietary Sugars and Endogenous Formation of Advanced Glycation Endproducts: Emerging Mechanisms of Disease. Nutrients 9(4) [DOI PMID]
Mastrocola R, Aragno M, Alloatti G, Collino M, Penna C, Pagliaro P. (2018) Metaflammation: Tissue-Specific Alterations of the NLRP3 Inflammasome Platform in Metabolic Syndrome. Current medicinal chemistry 25(11) 1294-1310 [DOI PMID]
Nigro D, Menotti F, Cento AS, Serpe L, Chiazza F, Dal Bello F, Romaniello F, Medana C, Collino M, Aragno M, Mastrocola R. (2017) Chronic administration of saturated fats and fructose differently affect SREBP activity resulting in different modulation of Nrf2 and Nlrp3 inflammasome pathways in mice liver. The Journal of nutritional biochemistry 42 160-171 [DOI PMID]
Mastrocola R. (2017) AGEs and neurodegeneration: the Nrf2/glyoxalase-1 interaction. Oncotarget 8(4) 5645-5646 [DOI PMID]
Mastrocola R, Penna C, Tullio F, Femmino S, Nigro D, Chiazza F, Serpe L, Collotta D, Alloatti G, Cocco M, Bertinaria M, Pagliaro P, Aragno M, Collino M. (2016) Pharmacological Inhibition of NLRP3 Inflammasome Attenuates Myocardial Ischemia/Reperfusion Injury by Activation of RISK and Mitochondrial Pathways. Oxidative medicine and cellular longevity 2016 5271251 [DOI PMID]
Benetti E, Mastrocola R, Vitarelli G, Cutrin JC, Nigro D, Chiazza F, Mayoux E, Collino M, Fantozzi R. (2016) Empagliflozin Protects against Diet-Induced NLRP-3 Inflammasome Activation and Lipid Accumulation. The Journal of pharmacology and experimental therapeutics 359(1) 45-53 [DOI PMID]
Mastrocola R, Nigro D, Cento AS, Chiazza F, Collino M, Aragno M. (2016) High-fructose intake as risk factor for neurodegeneration: Key role for carboxy methyllysine accumulation in mice hippocampal neurons. Neurobiology of disease 89 65-75 [DOI PMID]
Mastrocola R, Collino M, Penna C, Nigro D, Chiazza F, Fracasso V, Tullio F, Alloatti G, Pagliaro P, Aragno M. (2016) Maladaptive Modulations of NLRP3 Inflammasome and Cardioprotective Pathways Are Involved in Diet-Induced Exacerbation of Myocardial Ischemia/Reperfusion Injury in Mice. Oxidative medicine and cellular longevity 2016 3480637 [DOI PMID]
Mastrocola R, Nigro D, Chiazza F, Medana C, Dal Bello F, Boccuzzi G, Collino M, Aragno M. (2016) Fructose-derived advanced glycation end-products drive lipogenesis and skeletal muscle reprogramming via SREBP-1c dysregulation in mice. Free radical biology & medicine 91 224-35 [DOI PMID]
Chiazza F, Couturier-Maillard A, Benetti E, Mastrocola R, Nigro D, Cutrin JC, Serpe L, Aragno M, Fantozzi R, Ryffel B, Thiemermann C, Collino M. (2016) Targeting the NLRP3 Inflammasome to Reduce Diet-Induced Metabolic Abnormalities in Mice. Molecular medicine (Cambridge, Mass.) 21(1) 1025-1037 [DOI PMID]
De Stefanis D, Mastrocola R, Nigro D, Costelli P, Aragno M. (2017) Effects of chronic sugar consumption on lipid accumulation and autophagy in the skeletal muscle. European journal of nutrition 56(1) 363-373 [DOI PMID]
Mastrocola R, Collino M, Nigro D, Chiazza F, D'Antona G, Aragno M, Minetto MA. (2015) Accumulation of advanced glycation end-products and activation of the SCAP/SREBP Lipogenetic pathway occur in diet-induced obese mouse skeletal muscle. PloS one 10(3) e0119587 [DOI PMID]
Sansoe G, Mastrocola R, Aragno M, Parola M. (2014) Dynamics of sodium retention in preascitic cirrhotic rats assessed through parathyroid hormone injection. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 65(5) 649-57 [PMID]
Collino M, Mastrocola R, Nigro D, Chiazza F, Aragno M, D'Antona G, Minetto MA. (2014) Variability in myosteatosis and insulin resistance induced by high-fat diet in mouse skeletal muscles. BioMed research international 2014 569623 [DOI PMID]
Collino M, Benetti E, Rogazzo M, Chiazza F, Mastrocola R, Nigro D, Cutrin JC, Aragno M, Fantozzi R, Minetto MA, Thiemermann C. (2014) A non-erythropoietic peptide derivative of erythropoietin decreases susceptibility to diet-induced insulin resistance in mice. British journal of pharmacology 171(24) 5802-15 [DOI PMID]