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Dipartimento di Scienze Cliniche e Biologiche

Dipartimento di Scienze Cliniche e Biologiche

Logo di Dipartimento di Scienze Cliniche e Biologiche

Cristina Panuzzo

Ricercatore/Ricercatrice a tempo determinato di tipo A

Professore/Professoressa a contratto

Contatti

Presso

  • Dipartimento di Scienze Cliniche e Biologiche
  • Corso di Laurea in Tecniche di Laboratorio Biomedico - Cuneo

Prodotti della ricerca selezionati

PUBLICATIONS:

Number of Publications: 36

Number of Citations: 657

H-Index: 16

 

  1. Panuzzo C, Pironi L, Maglione A, Rocco S, Stanga S, Riganti C, Kopecka J, Ali MS, Pergolizzi B, Bracco E, Cilloni D. mTORC2 Is Activated under Hypoxia and Could Support Chronic Myeloid Leukemia Stem Cells. Int J Mol Sci. 2023 Jan 8;24(2):1234. doi: 10.3390/ijms24021234. PMID: 36674750; PMCID: PMC9865638.
  2. Panuzzo C, Jovanovski A, Ali MS, Cilloni D, Pergolizzi B. Revealing the Mysteries of Acute Myeloid Leukemia: From Quantitative PCR through Next-Generation Sequencing and Systemic Metabolomic Profiling. J Clin Med. 2022 Jan 18;11(3):483. doi: 10.3390/jcm11030483. PMID: 35159934; PMCID: PMC8836582.
  3. Ali MS, Magnati S, Panuzzo C, Cilloni D, Saglio G, Pergolizzi B, Bracco E. The Downregulation of Both Giant HERCs, <i>HERC1</i> and <i>HERC2</i>, Is an Unambiguous Feature of Chronic Myeloid Leukemia, and HERC1 Levels Are Associated with Leukemic Cell Differentiation. J Clin Med. 2022 Jan 10;11(2):324. doi: 3390/jcm11020324. PMID: 35054018; PMCID: PMC8778248.
  4. Biondo M, Panuzzo C, Ali SM, Bozzaro S, Osella M, Bracco E, Pergolizzi B. The Dynamics of Aerotaxis in a Simple Eukaryotic Model. Front Cell Dev Biol. 2021 Nov 23;9:720623. doi: 10.3389/fcell.2021.720623. PMID: 34888305; PMCID: PMC8650612.
  5. Ali MS, Panuzzo C, Calabrese C, Maglione A, Piazza R, Cilloni D, Saglio G, Pergolizzi B, Bracco E. The Giant HECT E3 Ubiquitin Ligase HERC1 Is Aberrantly Expressed in Myeloid Related Disorders and It Is a Novel BCR-ABL1 Binding Cancers (Basel). 2021 Jan 19;13(2):341. doi: 10.3390/cancers13020341. PMID: 33477751; PMCID: PMC7832311.
  6. Lo Iacono M, Signorino E, Petiti J, Pradotto M, Calabrese C, Panuzzo C, Caciolli F, Pergolizzi B, De Gobbi M, Rege-Cambrin G, Fava C, Giachino C, Bracco E, Saglio G, Frassoni F, Cilloni D. Genetic Screening for Potential New Targets in Chronic Myeloid Leukemia Based on Drosophila Transgenic for Human BCR-ABL1. Cancers (Basel). 2021 Jan 14;13(2):293. doi: 10.3390/cancers13020293. PMID: 33466839; PMCID: PMC7830713.
  7. Panuzzo C, Jovanovski A, Pergolizzi B, Pironi L, Stanga S, Fava C, Cilloni D. Mitochondria: A Galaxy in the Hematopoietic and Leukemic Stem Cell Universe. Int J Mol Sci. 2020 May 30;21(11):3928. doi: 10.3390/ijms21113928. PMID: 32486249; PMCID: PMC7312164.
  8. Panuzzo C, Signorino E, Calabrese C, Ali MS, Petiti J, Bracco E, Cilloni D. Landscape of Tumor Suppressor Mutations in Acute Myeloid Leukemia. J Clin Med. 2020 Mar 16;9(3):802. doi: 10.3390/jcm9030802. PMID: 32188030; PMCID: PMC7141302.
  9. Cilloni D, Ravera S, Calabrese C, Gaidano V, Niscola P, Balleari E, Gallo D, Petiti J, Signorino E, Rosso V, Panuzzo C, Sabatini F, Andreani G, Dragani M, Finelli C, Poloni A, Crugnola M, Voso MT, Fenu S, Pelizzari A, Santini V, Saglio G, Podestà M, Frassoni F. Iron overload alters the energy metabolism in patients with myelodysplastic syndromes: results from the multicenter FISM BIOFER study. Sci Rep. 2020 Jun 8;10(1):9156. doi: 10.1038/s41598-020-66162-y. PMID: 32514107; PMCID: PMC7280296.
  10. Calabrese C*, Panuzzo C*, Stanga S, Andreani G, Ravera S, Maglione A, Pironi L, Petiti J, Shahzad Ali MS, Scaravaglio P, Napoli F, Fava C, De Gobbi M, Frassoni F, Saglio G, Bracco E, Pergolizzi B, Cilloni D. Deferasirox-Dependent Iron Chelation Enhances Mitochondrial Dysfunction and Restores p53 Signaling by Stabilization of p53 Family Members in Leukemic Cells. Int J Mol Sci. 2020 Oct 16;21(20):7674. doi: 10.3390/ijms21207674. PMID: 33081324; PMCID: PMC7589297.* co-first
  11. Pergolizzi B, Panuzzo C, Ali MS, Lo Iacono M, Levra Levron C, Ponzone L, Prelli M, Cilloni D, Calautti E, Bozzaro S, Bracco E. Two conserved glycine residues in mammalian and <i>Dictyostelium</i> Rictor are required for mTORC2 activity and integrity. J Cell Sci. 2019 Nov 14;132(22): jcs236505. doi: 10.1242/jcs.236505. PMID: 31653780.
  12. Rosso V*, Panuzzo C*, Petiti J, Carturan S, Dragani M, Andreani G, Fava C, Saglio G, Bracco E, Cilloni D. Reduced Expression of Sprouty1 Contributes to the Aberrant Proliferation and Impaired Apoptosis of Acute Myeloid Leukemia Cells. J Clin Med. 2019 Jul 4;8(7):972. doi: 10.3390/jcm8070972. PMID: 31277439; PMCID: PMC6678378. * co-first
  13. Petiti J, Rosso V, Lo Iacono M, Panuzzo C, Calabrese C, Signorino E, Pironi L, Cartellà A, Bracco E, Pergolizzi B, Beltramo T, Fava C, Cilloni D. Curcumin induces apoptosis in JAK2-mutated cells by the inhibition of JAK2/STAT and mTORC1 pathways. J Cell Mol Med. 2019 Jun;23(6):4349-4357. doi: 10.1111/jcmm.14326. Epub 2019 Apr 29. PMID: 31033209; PMCID: PMC6533565.
  14. Morotti A, Torti D, Carra G, Panuzzo C, Crivellaro S, Taulli R, Fava C, Guerrasio A, Saglio G. Unleashing the Guardian: The Targetable BCR-ABL/HAUSP/PML/PTEN Network in Chronic Myeloid Leukemia. Curr Drug Targets. 2017;18(4):389-395. doi: 10.2174/1389450117666160608120527. PMID: 27291926.
  15. Casnici C, Crotta K, Volpe G, Panuzzo C, Lattuada D, Mesiano G, Saglio G, Marelli O. Specific Monoclonal Antibody Against Bcr/Abl Out-of-Frame Alternative Proteins as Diagnostic Tool in Chronic Myelogenous Leukemia Patients. Monoclon Antib Immunodiagn Immunother. 2017 Aug;36(4):149-156. doi: 10.1089/mab.2016.0054. Epub 2017 Jul 13. PMID: 28704165.
  16. Carrà G, Panuzzo C, Torti D, Parvis G, Crivellaro S, Familiari U, Volante M, Morena D, Lingua MF, Brancaccio M, Guerrasio A, Pandolfi PP, Saglio G, Taulli R, Morotti A. Therapeutic inhibition of USP7-PTEN network in chronic lymphocytic leukemia: a strategy to overcome TP53 mutated/deleted clones. Oncotarget. 2017 May 30;8(22):35508-35522. doi: 10.18632/oncotarget.16348. PMID: 28418900; PMCID: PMC5482594.
  17. Morotti A, Crivellaro S, Panuzzo C, Carrà G, Guerrasio A, Saglio G. IκB-α: At the crossroad between oncogenic and tumor-suppressive signals. Oncol Lett. 2017 Feb;13(2):531-534. doi: 10.3892/ol.2016.5465. Epub 2016 Dec 6. PMID: 28356925; PMCID: PMC5351326.
  18. Carturan S, Petiti J, Rosso V, Calabrese C, Signorino E, Bot-Sartor G, Nicoli P, Gallo D, Bracco E, Morotti A, Panuzzo C, Gottardi E, Frassoni F, Saglio G, Cilloni D. Variable but consistent pattern of Meningioma 1 gene (MN1) expression in different genetic subsets of acute myelogenous leukaemia and its potential use as a marker for minimal residual disease detection. 2016 Nov 8;7(45):74082-74096. doi: 10.18632/oncotarget.12269. PMID: 27765915; PMCID: PMC5342037.
  19. Carrà G, Panuzzo C, Crivellaro S, Morena D, Taulli R, Guerrasio A, Saglio G, Morotti A. The targetable role of herpes virus-associated ubiquitin-specific protease (HAUSP) in p190 BCR-ABL leukemia. Oncol Lett. 2016 Nov;12(5):3123-3126. doi: 10.3892/ol.2016.5073. Epub 2016 Sep 1. PMID: 27899971; PMCID: PMC5103907.
  20. Carrà G, Torti D, Crivellaro S, Panuzzo C, Taulli R, Cilloni D, Guerrasio A, Saglio G, Morotti A. The BCR-ABL/NF-κB signal transduction network: a long lasting relationship in Philadelphia positive Leukemias. Oncotarget. 2016 Oct 4;7(40):66287-66298. doi: 10.18632/oncotarget.11507. PMID: 27563822; PMCID: PMC5323234.
  21. Crivellaro S, Carrà G, Panuzzo C, Taulli R, Guerrasio A, Saglio G, Morotti A. The non-genomic loss of function of tumor suppressors: an essential role in the pathogenesis of chronic myeloid leukemia chronic phase. BMC Cancer. 2016 May 16;16:314. doi: 10.1186/s12885-016-2346-6. PMID: 27184141; PMCID: PMC4869339.
  22. Morotti A, Carrà G, Panuzzo C, Crivellaro S, Taulli R, Guerrasio A, Saglio G. Protein Kinase CK2: A Targetable BCR-ABL Partner in Philadelphia Positive Leukemias. Adv Hematol. 2015;2015:612567. doi: 10.1155/2015/612567. Epub 2015 Dec 30. PMID: 26843864; PMCID: PMC4710905.
  23. Morotti A, Panuzzo C, Crivellaro S, Carrà G, Torti D, Guerrasio A, Saglio G. The Role of PTEN in Myeloid Malignancies. Hematol Rep. 2015 Dec 9;7(4):5844. doi: 10.4081/hr.2015.6027. PMID: 26734127; PMCID: PMC4691678.
  24. Panuzzo C, Volpe G, Cibrario Rocchietti E, Casnici C, Crotta K, Crivellaro S, Carrà G, Lorenzatti R, Peracino B, Torti D, Morotti A, Camacho-Leal MP, Defilippi P, Marelli O, Saglio G. New alternative splicing BCR/ABL-OOF shows an oncogenic role by lack of inhibition of BCR GTPase activity and an increase of persistence of Rac activation in chronic myeloid leukemia. Oncoscience. 2015 Nov 11;2(10):880-91. doi: 10.18632/oncoscience.260. PMID: 26682280; PMCID: PMC4671955.
  25. Crivellaro S, Panuzzo C, Carrà G, Volpengo A, Crasto F, Gottardi E, Familiari U, Papotti M, Torti D, Piazza R, Redaelli S, Taulli R, Guerrasio A, Saglio G, Morotti A. Non genomic loss of function of tumor suppressors in CML: BCR-ABL promotes IκBα mediated p53 nuclear exclusion. Oncotarget. 2015 Sep 22;6(28):25217-25. doi: 10.18632/oncotarget.4611. PMID: 26295305; PMCID: PMC4694826.
  26. Morotti A, Panuzzo C, Crivellaro S, Carrà G, Fava C, Guerrasio A, Pandolfi PP, Saglio G. BCR-ABL inactivates cytosolic PTEN through Casein Kinase II mediated tail phosphorylation. Cell Cycle. 2015;14(7):973-9. doi: 10.1080/15384101.2015.1006970. PMID: 25608112; PMCID: PMC4615112.
  27. Di Savino A*, Panuzzo C*, Rocca S, Familiari U, Piazza R, Crivellaro S, Carrà G, Ferretti R, Fusella F, Giugliano E, Camporeale A, Franco I, Miniscalco B, Cutrin JC, Turco E, Silengo L, Hirsch E, Rege-Cambrin G, Gambacorti-Passerini C, Pandolfi PP, Papotti M, Saglio G, Tarone G, Morotti A, Brancaccio M. Morgana acts as an oncosuppressor in chronic myeloid leukemia. Blood. 2015 Apr 2;125(14):2245-53. doi: 10.1182/blood-2014-05-575001. Epub 2015 Feb 12. PMID:25678499. * co-first
  28. Morotti A*, Panuzzo C*, Crivellaro S, Carrà G, Guerrasio A, Saglio G. HAUSP compartmentalization in chronic myeloid leukemia. Eur J Haematol. 2015 Apr;94(4):318-21. doi: 10.1111/ejh.12422. Epub 2014 Sep 3. PMID: 25082234. * co-first
  29. Gambacorti-Passerini CB, Donadoni C, Parmiani A, Pirola A, Redaelli S, Signore G, Piazza V, Malcovati L, Fontana D, Spinelli R, Magistroni V, Gaipa G, Peronaci M, Morotti A, Panuzzo C, Saglio G, Usala E, Kim DW, Rea D, Zervakis K, Viniou N, Symeonidis A, Becker H, Boultwood J, Campiotti L, Carrabba M, Elli E, Bignell GR, Papaemmanuil E, Campbell PJ, Cazzola M, Piazza R. Recurrent ETNK1 mutations in atypical chronic myeloid leukemia. 2015 Jan 15;125(3):499-503. doi: 10.1182/blood-2014-06-579466. Epub 2014 Oct 24. PMID:25343957.
  30. Panuzzo C, Crivellaro S, Carrà G, Guerrasio A, Saglio G, Morotti A. BCR-ABL promotes PTEN downregulation in chronic myeloid leukemia. PLoS One. 2014 Oct 24;9(10):e110682. doi: 10.1371/journal.pone.0110682. PMID: 25343485; PMCID: PMC4208795.
  31. Morotti A, Panuzzo C, Crivellaro S, Pergolizzi B, Familiari U, Berger AH, Saglio G, Pandolfi PP. BCR-ABL disrupts PTEN nuclear-cytoplasmic shuttling through phosphorylation-dependent activation of HAUSP. Leukemia. 2014 Jun;28(6):1326-33. doi: 10.1038/leu.2013.370. Epub 2013 Dec 9. PMID: 24317448.
  32. Morotti A, Panuzzo C, Fava C, Saglio G. Kinase-inhibitor-insensitive cancer stem cells in chronic myeloid leukemia. Expert Opin Biol Ther. 2014 Mar;14(3):287-99. doi: 10.1517/14712598.2014.867323. Epub 2014 Jan 3. PMID: 24387320.
  33. Casnici C, Volpe G, Crotta K, Panuzzo C, Lattuada D, Cabras CA, Longhi R, Saglio G, Marelli O. Characterization of a monoclonal antibody specific for novel Bcr/Abl out-of-frame fusion proteins. Hybridoma (Larchmt). 2011 Jun;30(3):261-9. doi: 10.1089/hyb.2010.0122. PMID: 21707361.
  34. Casnici C, Volpe G, Lattuada D, Crotta K, Kuka M, Panuzzo C, Mastrotto C, Tonon G, Fazio VM, Saglio G, Marelli O. Out of frame peptides from BCR/ABL alternative splicing are immunogenic in HLA A2.1 transgenic mice. Cancer Lett. 2009 Apr 8;276(1):61-7. doi: 10.1016/j.canlet.2008.10.032. Epub 2008 Dec 4. PMID: 19062160.
  35. Volpe G, Panuzzo C, Ulisciani S, Cilloni D. Imatinib resistance in CML. Cancer Lett. 2009 Feb 8;274(1):1-9. doi: 10.1016/j.canlet.2008.06.003. Epub 2008 Jul 23. PMID: 18653275.
  36. Volpe G, Cignetti A, Panuzzo C, Kuka M, Vitaggio K, Brancaccio M, Perrone G, Rinaldi M, Prato G, Fava M, Geuna M, Pautasso M, Casnici C, Signori E, Tonon G, Tarone G, Marelli O, Fazio VM, Saglio G. Alternative BCR/ABL splice variants in Philadelphia chromosome-positive leukemias result in novel tumor-specific fusion proteins that may represent potential targets for immunotherapy approaches. Cancer Res. 2007 Jun 1;67(11):5300-7. doi: 10.1158/0008-5472.CAN-06-3737. PMID: 17545610.

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