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Applied Biology - Retta

1. Goitre L, DiStefano PV, Moglia A, Nobiletti N, Baldini E, Trabalzini L, Keubel J, Trapani E, Shuvaev VV, Muzykantov VR, Sarelius IH, Retta SF* & Glading AJ. (2017). Up-regulation of NADPH oxidase-mediated redox signaling contributes to the loss of barrier function in KRIT1 deficient endothelium. Scientific Reports, 2017 Aug 15;7(1):8296.

2. Retta SF* and Glading AJ. (2016). Oxidative stress and inflammation in cerebral cavernous malformation disease pathogenesis: Two sides of the same coin. International Journal of Biochemistry & Cell Biolology, 2016 Dec; 81(Pt B):254-270.

3. Choquet H, Trapani E, Goitre L, Trabalzini L, Akers A., Fontanella M, Hart BL, Morrison LA, Pawlikowska L, Kim H, Retta SF*. (2016). Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in Cerebral Cavernous Malformation type 1. Free Radical Biology and Medicine, 2016 Jan 19;92:100-109.

4. Marchi S, Corricelli M, Trapani E, Bravi L, Pittaro A, Delle Monache S, Ferroni L, Patergnani S, Missiroli S, Goitre L, Trabalzini L, Rimessi A, Giorgi C, Zavan B, Cassoni P, Dejana E, Retta SF*, Pinton P. (2015). Defective autophagy is a key feature of cerebral cavernous malformations. EMBO Molecular Medicine, 2015. 7(11):1403-1417.

5. Goitre L, De Luca E, Braggion S, Trapani E, Guglielmotto M, Biasi F, Forni M, Moglia A, Trabalzini L, Retta SF*. (2014) KRIT1 loss of function causes a ROS-dependent upregulation of c-Jun. Free Radical Biology and Medicine, 2014 Mar; 68:134-47.

 

Cellular and Molecular Biology Group

Gelatin-based hydrogel for vascular endothelial growth factor release in peripheral nerve tissue engineering. Gnavi S, di Blasio L, Tonda-Turo C, Mancardi A, Primo L, Ciardelli G, Gambarotta G, Geuna S, Perroteau I. Journal of Tissue Engineering and Regenerative Medicine (2017) 11:459-470. doi: 10.1002/term.1936 

The Neuregulin1/ErbB system is selectively regulated during peripheral nerve degeneration and regeneration. Ronchi G, Haastert-Talini K, Fornasari BE, Perroteau I, Geuna S, Gambarotta G. European Journal of Neuroscience (2016) 43:351-64. doi: 10.1111/ejn.12974 

Neuregulin1 alpha activates migration of neuronal progenitors expressing ErbB4. Fornasari BE, El Soury M, De Marchis S, Perroteau I, Geuna S, Gambarotta G. Molecular and Cellular Neuroscience (2016) 77:87-94. doi: 10.1016/j.mcn.2016.10.008 

Local delivery of the Neuregulin1 receptor ecto-domain (ecto-ErbB4) has a positive effect on regenerated nerve fiber maturation. Gambarotta G, Pascal D, Ronchi G, Morano M, Jager SB, Moimas S, Zentilin L, Giacca M, Perroteau I, Tos P, Geuna S, Raimondo S. Gene Therapy (2015) 22:901-7. doi: 10.1038/gt.2015.46 

Identification and validation of suitable housekeeping genes for normalizing quantitative real-time PCR assays in injured peripheral nerves. Gambarotta G, Ronchi G, Friard O, Galletta P, Perroteau I, Geuna S. PLoS One (2014)  9(8):e105601. doi: 10.1371/journal.pone.0105601

 

Clinical and Molecular Hematology

Publications (last 5 years) 

-          Buckstein R, Balleari E, Wells R, Santini V, Sanna A, Salvetti C, Crisà E, Allione B, Danise P, Finelli C, Clavio M, Poloni A, Salvi F, Cilloni D, Oliva EN, Musto P, Houston B, Zhu N, Geddes M, Leitch H, Leber B, Sabloff M, Nevill TJ, Yee KW, Storring JM, Francis J, Maurillo L, Latagliata R, Spiriti MAA, Andriani A, Piccioni AL, Fianchi L, Fenu S, Gumenyuk S, Buccisano F. ITACA: A new validated international erythropoietic stimulating agent-response score that further refines the predictive power of previous scoring systems. Am J Hematol. 2017;92:1037-1046 

-          Pellegrino RM, Riondato F, Ferbo L, Boero M, Palmieri A, Osella L, Pollicino P, Miniscalco B, Saglio G,Roetto A. Altered Erythropoiesis in Mouse Models of Type 3 Hemochromatosis. Biomed Res Int. 2017;2017:2408941. 

-          Carrà G, Panuzzo C, Torti D, Parvis G, Crivellaro S, Familiari U, Volante M, Morena D, Lingua MF, Brancaccio M, Guerrasio A, Pandolfi PP, Saglio G, Taulli R, Morotti A. Therapeutic inhibition of USP7-PTEN network in chronic lymphocytic leukemia: a strategy to overcome TP53 mutated/deleted clones. Oncotarget. 2017;8:35508-35522 

-          Messa E, Biale L, Castiglione A, Lunghi M, Bonferroni M, Salvi F, Allione B, Ferrero D, Calabrese C, De Gobbi M, Nicoli P, Gioia D, Levis A, Saglio G, Cilloni D. Erythroid response during iron chelation therapy in a cohort of patients affected by hematologic malignancies and aplastic anemia with transfusion requirement and iron overload: a FISM Italian multicenter retrospective study. Leuk Lymphoma. 2017;58:2752-2754 

-          Piubelli C, Castagna A, Marchi G, Rizzi M, Busti F, Badar S, Marchetti M, De Gobbi M, Roetto A, Xumerle L, Suku E, Giorgetti A, Delledonne M, Olivieri O, Girelli D. Identification of new BMP6 pro-peptide mutations in patients with iron overload. Am J Hematol. 2017;92:562-568 

-          Collord G, Park N, Podestà M, Dagnino M, Cilloni D, Jones D, Varela I, Frassoni F, Vassiliou GS. Clonal haematopoiesis is not prevalent in survivors of childhood cancer. Br J Haematol. 2017 Apr 3. doi: 10.1111/bjh.14630. [Epub ahead of print] 

-          Fava C, Saglio G. The biology of CML supports second-generation TKIs as frontline treatment. Clin Adv Hematol Oncol. 2017;15:302-307 

-          Castagnetti F, Gugliotta G, Breccia M, Iurlo A, Levato L, Albano F, Vigneri P, Abruzzese E, Rossi G, Rupoli S, Cavazzini F, Martino B, Orlandi E, Pregno P, Annunziata M, Usala E, Tiribelli M, Sica S, Bonifacio M, Fava C, Gherlinzoni F, Bocchia M, Soverini S, Bochicchio MT, Cavo M, Giovanni M, Saglio G, Pane F, Baccarani M, Rosti G; GIMEMA CML Working Party. The BCR-ABL1 transcript type influences response and outcome in Philadelphia chromosome-positive chronic myeloid leukemia patients treated frontline with imatinib. Am J Hematol. 2017;92:797-805 

-          Di Savino A, Gaidano V, Palmieri A, Crasto F, Volpengo A, Lorenzatti R, Scaravaglio P, Manello A, Nicoli P, Gottardi E, Saglio G, Cilloni D, De Gobbi MClinical significance of TFR2 and EPOR expression in bone marrow cells in myelodysplastic syndromes. Br J Haematol. 2017;176:491-495 

-          Rosso V, Petiti J, Bracco E, Pedrola R, Carnuccio F, Signorino E, Carturan S, Calabrese C, Bot-Sartor G, Ronconi M, Serra A, Saglio G, Frassoni F, Cilloni D. A novel assay to detect calreticulin mutations in myeloproliferative neoplasms. Oncotarget. 2017;8:6399-6405 

-          Gorello P, Arcioni F, Palmieri A, Barbanera Y, Ceccuzzi L, Adami C, Marchesi M, Angius A, Minelli O, Onorato M, Piga A, Caniglia M, Mecucci C, Roetto A. TThe Molecular Spectrum of β- and α-Thalassemia Mutations in Non-Endemic Umbria, Central Italy. Hemoglobin. 2016;40:371-376. 

-          Guaraldo M, Santambrogio P, Rovelli E, Di Savino A, Saglio G, Cittaro D,Roetto A, Levi S. Characterization of human mitochondrial ferritin promoter: identification of transcription factors and evidences of epigenetic control. Sci Rep. 2016;6:33432. 

-          Fava C, Rege-Cambrin G, Dogliotti I, Gottardi E, Berchialla P, Di Gioacchino B, Crasto F, Lorenzatti R, Volpengo A, Daraio F, Fantino C, Saglio GEarly BCR-ABL1 Reduction Is Predictive of Better Event-free Survival in Patients With Newly Diagnosed Chronic Myeloid Leukemia Treated With Any Tyrosine Kinase Inhibitor. Clin Lymphoma Myeloma Leuk. 2016;16 Suppl:S96-S100 

-          Baschant U, Rauner M, Balaian E, Weidner H, Roetto A, Platzbecker U, Hofbauer LC. Wnt5a is a key target for the pro-osteogenic effects of iron chelation on osteoblast progenitors. Haematologica. 2016;101:1499-1507 

-          Pellegrino RM, Boda E, Montarolo F, Boero M, Mezzanotte M, Saglio G, Buffo A, Roetto ATransferrin Receptor 2 Dependent Alterations of Brain Iron Metabolism Affect Anxiety Circuits in the Mouse. Sci Rep. 2016;6:30725 

-          Ferbo L, Manzini PM, Badar S, Campostrini N, Ferrarini A, Delledonne M, Francisci T, Tassi V, Valfrè A, Dall'omo AM, D'antico S, Girelli D, Roetto A, De Gobbi MDetection of a rare mutation in the ferroportin gene through targeted next generation sequencing. Blood Transfus. 2016;14:531-534 

-          Boero M, Pagliaro P, Tullio F, Pellegrino RM, Palmieri A, Ferbo L, Saglio G, De Gobbi M, Penna C, Roetto AA comparative study of myocardial molecular phenotypes of two tfr2β null mice: role in ischemia/reperfusion. Biofactors. 2015;41:360-71

-          Rosso V, Bracco E, Pedrola R, Carturan S, Signorino E, Petiti J, Calabrese C, Nicoli P, De Gobbi M, Gaidano V, Gallo D, Ulisciani S, Fava C, Rege-Cambrin G, Frassoni F, Saglio G, Cilloni DDetection of BCR-ABL T315I mutation by peptide nucleic acid directed PCR clamping and by peptide nucleic acid FISH. Biomark Res. 2015;3:15 

-          Nicoli P, Calabrese C, Pellegrino RM, Rosso V, Bracco E, Signorino E, Carturan S, Petiti J, Gallo D, Gaidano V, De Gobbi M, Roetto A, Saglio G, Cilloni DDevelopment of cellular and humoral response against WT1 protein vaccination in mice. Am J Hematol. 2015;90:E193-4 

-          Di Savino A, Panuzzo C, Rocca S, Familiari U, Piazza R, Crivellaro S, CarràG,Ferretti R, Fusella F, Giugliano E, Camporeale A, Franco I, Miniscalco B, Cutrin JC, Turco E, Silengo L, Hirsch E, Rege-Cambrin G, Gambacorti-Passerini C, Pandolfi PP, Papotti M, Saglio G, Tarone G, Morotti A, Brancaccio M. Morgana acts as an oncosuppressor in chronic myeloid leukemia. Blood. 2015;125:2245-53. 

-          Gugliotta G, Castagnetti F, Breccia M, Levato L, D'Adda M, Stagno F, Tiribelli M, Salvucci M, Fava C, Martino B, Cedrone M, Bocchia M, Trabacchi E, Cavazzini F, Usala E, Russo Rossi A, Bochicchio MT, Soverini S, Alimena G, Cavo M, Pane F, Martinelli G, Saglio G, Baccarani M, Rosti G; GIMEMA CML Working Party. Long-term outcome of a phase 2 trial with nilotinib 400 mg twice daily in first-line treatment of chronic myeloid leukemia. Haematologica. 2015;100:1146-50 

-          Hughes JR, Roberts N, McGowan S, Hay D, Giannoulatou E, Lynch M, De Gobbi M, Taylor S, Gibbons R, Higgs DR. Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment. Nat Genet. 2014;46:205-12

 -          Morotti A, Panuzzo C, Crivellaro S, Pergolizzi B, Familiari U, Berger AH,Saglio G, Pandolfi PP. BCR-ABL disrupts PTEN nuclear-cytoplasmic shuttling through phosphorylation-dependent activation of HAUSP. Leukemia. 2014;28:1326-33 

-          Nai A, Pellegrino RM, Rausa M, Pagani A, Boero M, Silvestri L, Saglio GRoetto A, Camaschella C. The erythroid function of transferrin receptor 2 revealed by Tmprss6 inactivation in different models of transferrin receptor 2 knockout mice. Haematologica. 2014;99:1016-21 

-          Hosseini M, Goodstadt L, Hughes JR, Kowalczyk MS, De Gobbi M, Otto GW, Copley RR, Mott R, Higgs DR, Flint J. Causes and consequences of chromatin variation between inbred mice. PLoS Genet. 2013;9:e1003570 

-          Lower KM, De Gobbi M, Hughes JR, Derry CJ, Ayyub H, Sloane-Stanley JA, Vernimmen D, Garrick D, Gibbons RJ, Higgs DR. Analysis of sequence variation underlying tissue-specific transcription factor binding and gene expression. Hum Mutat. 2013;34:1140-8 

-          Roetto A, Porto G. A novel mutation in the CUB sequence of matriptase-2 (TMPRSS6) is implicated in iron-resistant iron deficiency anaemia -- response to Jaspers et al. Br J Haematol. 2013;160:566-7 

-          Russo D, Martinelli G, Malagola M, Skert C, Soverini S, Iacobucci I, De Vivo A, Testoni N, Castagnetti F, Gugliotta G, Turri D, Bergamaschi M, Pregno P, Pungolino E, Stagno F, Breccia M, Martino B, Intermesoli T, Fava C, Abruzzese E, Tiribelli M, Bigazzi C, Cesana BM, Rosti G, Baccarani M. Effects and outcome of a policy of intermittent imatinib treatment in elderly patients with chronic myeloid leukemia. Blood. 2013;121:5138-44

General Pathology - Autelli Riccardo - Mechanisms of autophagy-mediated anticancer drug resistance of breast and liver cancer cells

Autelli, R.; Costelli, P.; Crepaldi, T.; Penna, F.; Tamagno, E. (2016)
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
https://iris.unito.it/handle/2318/1550759

Ullio, Chiara, Brunk, Ulf T , Urani, Chiara, Melchioretto, Pasquale, Bonelli, Gabriella, Baccino, Francesco M , Autelli, Riccardo (2015)
AUTOPHAGY OF METALLOTHIONEINS PREVENTS TNF-INDUCED OXIDATIVE STRESS AND TOXICITY IN HEPATOMA CELLS.
https://iris.unito.it/handle/2318/1550662

Cannito S, Turato C, Paternostro C, Biasiolo A, Colombatto S, Cambieri I, Quarta S, Novo E, Morello E, Villano G, Cillo U, Fasolato S, Musso T, David E, Tusa I, Rovida E, Autelli R, Smedile A, Cillo U, Pontisso P, Parola M (2015)
Hypoxia up-regulates SERPINB3 through HIF-2? in human liver cancer cells.
https://iris.unito.it/handle/2318/154507

C BOCCA, M IEVOLELLA, R AUTELLI, M MOTTA, L MOSSO, B TORCHIO, F BOZZO, S CANNITO, C PATERNOSTRO, S COLOMBATTO, M PAROLA, A MIGLIETTA (2014)
EXPRESSION OF COX-2 IN HUMAN BREAST CANCER CELLS AS A CRITICAL DETERMINANT OF EPITHELIAL-MESENCHYMAL TRANSITION AND INVASIVENESS.
https://iris.unito.it/handle/2318/139953

C Ullio, J Casas, U T Brunk, G Sala, G Fabriàs, R Ghidoni, G Bonelli, F M Baccino, R Autelli (2013)
LYSOSOMAL MECHANISMS OF DEATH BY TNF IN HEPATOMA CELLS.
https://iris.unito.it/handle/2318/152996

Autelli R, Ullio C, Prigione E, Crepaldi S, Schiavone N, Brunk UT, Capaccioli S, Baccino FM, Bonelli G (2009)
Divergent pathways for TNF and C(2)-ceramide toxicity in HTC hepatoma cells.
https://iris.unito.it/handle/2318/57488

General Pathology - Cancer cachexia

Publications

  • F. Penna, A. Bonetto, Z. Aversa, V.G. Minero, F. Rossi Fanelli, P. Costelli, M. Muscaritoli (2016). Effect of the specific proteasome inhibitor bortezomib on cancer-related muscle  wasting. J. Cachexia, Sarcopenia and Muscle, 7: 345-354.
  • Z. Aversa, F. Pin, S. Lucia, F. Penna, R. Verzaro, M. Fazi, G. Colasante, A. Tirone, F. Rossi Fanelli, C. Ramaccini, P. Costelli, M. Muscaritoli (2016). Autophagy is induced in the skeletal muscle of cachectic cancer patients. Sci. Rep., 6: 30340.
  • Camperi,  F. Pin, D. Costamagna, F. Penna, M. Lopez, Z. Aversa, T. Zimmers, R. Verzaro, R. Fittipaldi, G. Caretti, F.M. Baccino, M. Muscaritoli, P. Costelli (2017). Vitamin D and VDR in cancer cachexia and muscle regeneration. Oncotarget, 8: 21778-21793.
  • M. Segatto, R. Fittipaldi, F. Pin, R. Sartori, K. Dae Ko, H. Zare, C. Fenizia, G. Zanchettin, E. Pierobon, S. Hatakeyama, C. Sperti, S. Merigliano, M. Sandri, P. Filippakopoulos, P. Costelli, V. Sartorelli, G. Caretti (2017) Epigenetic Targeting of Bromodomain Protein BRD4 Counteracts Cancer Cachexia and Prolongs Survival. Nature Commun., in press.
  • F. Molinari, F. Pin, S. Gorini, S. Chiandotto, L. Pontecorvo, E. Rizzuto, S. Pisu, A. Musaro, F. Penna, P. Costelli, G. Rosano, E. Ferraro (2017). The mitochondrial metabolic reprogramming agent trimetazidine as an 'exercise mimetic' in cachectic C26-bearing mice. J. Cachexia, Sarcopenia and Muscle, in press.

 

General Pathology - Oxidative stress and chemoresistance.

  1. Ciamporcero E, Shen H, Ramakrishnan S, Yu Ku S, Chintala S, Shen L, Adelaiye R, Miles KM, Ullio C, Pizzimenti S, Daga M, Azabdaftari G, Attwood K, Johnson C, Zhang J, Barrera G, Pili R. YAP activation protects urothelial cell carcinoma from treatment-induced DNA damage. Oncogene. 2016 Mar 24;35(12):1541-53. doi:10.1038/onc.2015.219.
  2. Lanzardo S, Conti L, Rooke R, Ruiu R, Accart N, Bolli E, Arigoni M, Macagno M, Barrera G, Pizzimenti S, Aurisicchio L, Calogero RA, Cavallo F. Immunotargeting of Antigen xCT Attenuates Stem-like Cell Behavior and Metastatic Progression in Breast Cancer. Cancer Res. 2016 Jan 1;76(1):62-72. doi: 10.1158/0008-5472.CAN-15-1208.
  3. Daga M, Ullio C, Argenziano M, Dianzani C, Cavalli R, Trotta F, Ferretti C, Zara GP, Gigliotti CL, Ciamporcero ES, Pettazzoni P, Corti D, Pizzimenti S, Barrera G. GSH-targeted nanosponges increase doxorubicin-induced toxicity "in vitro" and "in vivo" in cancer cells with high antioxidant defenses.  Free Radic Biol Med. 2016 Aug;97:24-37. doi: 10.1016/j.freeradbiomed.2016.05.009
  4. Barrera G, Daga M, Ferrara B, Dianzani C, Pizzimenti S, Argenziano M, Cavalli R, Trotta F. Drug delivery nanoparticles in treating chemoresistant tumor cells. Curr Med Chem. 2016 Dec 5. [Epub ahead of print].
  5. Gigliotti CL, Ferrara B, Occhipinti S, Boggio E, Barrera G, Pizzimenti S, Giovarelli M, Fantozzi R, Chiocchetti A, Argenziano M, Clemente N, Trotta F, Marchiò C, Annaratone L, Boldorini R, Dianzani U, Cavalli R, Dianzani C. Enhanced cytotoxic effect of camptothecin nanosponges in anaplastic thyroid cancer cells in vitro and in vivo on orthotopic xenograft tumors. Drug Deliv. 2017 Nov;24(1):670-680. doi: 10.1080/10717544.2017.1303856
  6. Ciamporcero E, Daga M, Pizzimenti S, Roetto A, Dianzani C, Compagnone A,
    Palmieri A, Ullio C, Cangemi L, Pili R, Barrera G. Crosstalk between Nrf2 and YAP
    contributes to maintaining the antioxidant potential and chemoresistance in
    bladder cancer. Free Radic Biol Med. 2018 Feb 1;115:447-457. doi:
    10.1016/j.freeradbiomed.2017.12.005. Epub 2017 Dec 14. PubMed PMID: 29248722.
  7. Daga M, Pizzimenti S, Dianzani C, Cucci MA, Cavalli R, Grattarola M, Ferrara
    B, Scariot V, Trotta F, Barrera G. Ailanthone inhibits cell growth and migration
    of cisplatin resistant bladder cancer cells through down-regulation of Nrf2, YAP,
    and c-Myc expression. Phytomedicine. 2019 Mar 15;56:156-164. doi:
    10.1016/j.phymed.2018.10.034. Epub 2018 Oct 29. PubMed PMID: 30668336.
  8. Cucci MA, Compagnone A, Daga M, Grattarola M, Ullio C, Roetto A, Palmieri A,
    Rosa AC, Argenziano M, Cavalli R, Simile MM, Pascale RM, Dianzani C, Barrera G,
    Pizzimenti S. Post-translational inhibition of YAP oncogene expression by
    4-hydroxynonenal in bladder cancer cells. Free Radic Biol Med. 2019
    Sep;141:205-219. doi: 10.1016/j.freeradbiomed.2019.06.009. Epub 2019 Jun 15.
    PubMed PMID: 31207288.

General Pathology - Polyunsaturated fatty acids in oncology and Tissue regeneration

PUBBLICATIONS

1) Muzio G, Miola M, Ferraris S, Maggiora M, Bertone E, Puccinelli MP, Ricci M, Borroni E, Canuto RA, Verné E, Follenzi A. Innovative superparamagnetic iron-oxide nanoparticles coated with silica and conjugated with linoleic acid: Effect on tumor cell growth and viability. Mater Sci Eng C Mater Biol Appl. 2017 Jul 1;76:439-447. doi: 10.1016/j.msec.2017.03.063. Epub 2017 Mar

2) Muzio G, Ricci M, Traverso N, Monacelli F, Oraldi M, Maggiora M, Canuto RA. 4-Hydroxyhexenal and 4-hydroxynonenal are mediators of the anti-cachectic effect of n-3 and n-6 polyunsaturated fatty acids on human lung cancer cells. Free Radic Biol Med. 2016 Oct;99:63-70. doi: 10.1016/j.freeradbiomed.2016.07.031. Epub 2016 Jul 30.

3) Muzio G, Perero S, Miola M, Oraldi M, Ferraris S, Vernè E, Festa F, Canuto RA, Festa V, Ferraris M. Biocompatibility versus peritoneal mesothelial cells of polypropylene prostheses for hernia repair, coated with a thin silica/silver layer. J Biomed Mater Res B Appl Biomater. 2017 Aug;105(6):1586-1593. doi: 10.1002/jbm.b.33697. Epub 2016 Apr 29.

4) Muzio G, Miola M, Perero S, Oraldi M, Maggiora Ma, Ferraris S, Vernè E, Festa V, Festa F, Canuto RA, Ferraris M. Polypropylene prostheses coated with silver nanoclusters/silica coating obtained by sputtering: Biocompatibility and antibacterial properties. Surface & Coatings Technology 319 (2017) 326-334.

5) Muzio G, Martinasso G, Baino F, Frairia R, Vitale-Brovarone C, Canuto RA. Key role of the expression of bone morphogenetic proteins in increasing the osteogenic activity of osteoblast-like cells exposed to shock waves and seeded on bioactive glass-ceramic scaffolds for bone tissue engineering. J Biomater Appl. 2014 Nov;29(5):728-36. doi: 10.1177/0885328214541974. Epub 2014 Jul 2.

 

Genomic Regulation Group

http://publicationslist.org/mdebortoli

http://publicationslist.org/santina.cutrupi

 

Laboratory of Cell Biology

Publications (2003-2017)

Pergolizzi B, Bozzaro S, Bracco E. (2019) Dictyostelium as model for studying ubiquitination and deubiquitination. The International journal of developmental biology 63(8-9-10) 529-539 [DOI  PMID]

Pergolizzi B, Panuzzo C, Ali MS, Lo Iacono M, Levra Levron C, Ponzone L, Prelli M, Cilloni D, Calautti E, Bozzaro S, Bracco E. (2019) Two conserved glycine residues in mammalian and Dictyostelium Rictor are required for mTORC2 activity and integrity. Journal of cell science 132(22) [DOI  PMID]

Petiti J, Rosso V, Lo Iacono M, Panuzzo C, Calabrese C, Signorino E, Pironi L, Cartella A, Bracco E, Pergolizzi B, Beltramo T, Fava C, Cilloni D. (2019) Curcumin induces apoptosis in JAK2-mutated cells by the inhibition of JAK2/STAT and mTORC1 pathways. Journal of cellular and molecular medicine 23(6) 4349-4357 [DOI  PMID]

A short evolutionary journey across the HERC Ubiquitin Ligases
Enrico Bracco2*, Cristina Panuzzo1, Barbara Pergolizzi1* 1Dept. of Clinical & Biological Sciences, University of Turin Italy 2Dept. of Oncology, University of Turin, Italy J Immunol Sci. (2018); 2(1): 46-49

Pergolizzi B, Carriero V, Abbadessa G, Penna C, Berchialla P, De Francia S, Bracco E, Racca S. (2017) Subchronic nandrolone administration reduces cardiac oxidative markers during restraint stress by modulating protein expression patterns. Molecular and cellular biochemistry 434(1-2) 51-60 [DOI  PMID]

Bracco E, Pergolizzi B. (2014) Ras proteins signaling in the early metazoan Dictyostelium discoideum. Methods in molecular biology (Clifton, N.J.) 1120 407-20 [DOI  PMID]

Pergolizzi B, Bozzaro S, Bracco E. (2017) G Protein-Dependent Signal Transduction and Ubiquitination in Dictyostelium. International journal of molecular sciences 18(10) [DOI  PMID]

Pergolizzi B, Bracco E, Bozzaro S (2017) A new HECT ubiquitin ligase regulating chemotaxis and development in Dictyostelium. Journal of Cell Science 130, 551-562

Bozzaro S. (2015) Emergence of Microbial Resistance During Hospitalization. EBioMedicine 2(9) 1022 [DOI  PMID]

Buracco S, Peracino B, Cinquetti R, Signoretto E, Vollero A, Imperiali F, Castagna M, Bossi E, Bozzaro S. (2015) Dictyostelium Nramp1, which is structurally and functionally similar to mammalian DMT1 transporter, mediates phagosomal iron efflux. Journal of cell science 128, 3304-16 [DOI  PMID]

Bozzaro S, Buracco S, Peracino B. (2013) Iron metabolism and resistance to infection by invasive bacteria in the social amoeba Dictyostelium discoideum. Frontiers in cellular and infection microbiology 3 50 [DOI  PMID]

Bozzaro S. (2013) The model organism Dictyostelium discoideum. Methods in molecular biology (Clifton, N.J.) 983 17-37 [DOI  PMID]

Bozzaro S, Peracino B, Eichinger L. (2013) Dictyostelium host response to legionella infection: strategies and assays. Methods in molecular biology (Clifton, N.J.) 954 417-38 [DOI  PMID]

Peracino B, Buracco S, Bozzaro S. (2013) The Nramp (Slc11) proteins regulate development, resistance to pathogenic bacteria and iron homeostasis in Dictyostelium discoideum. Journal of cell science 126(Pt 1) 301-11 [DOI  PMID]

Sillo A, Matthias J, Konertz R, Bozzaro S, Eichinger L. (2011) Salmonella typhimurium is pathogenic for Dictyostelium cells and subverts the starvation response. Cellular microbiology 13(11) 1793-811 [DOI  PMID]

Balest A, Peracino B, Bozzaro S. (2011) Legionella pneumophila infection is enhanced in a RacH-null mutant of Dictyostelium. Communicative & integrative biology 4(2) 194-7 [DOI  PMID]

Bozzaro S, Eichinger L. (2011) The professional phagocyte Dictyostelium discoideum as a model host for bacterial pathogens. Current drug targets 12(7) 942-54 [PMID]

Peracino B, Balest A, Bozzaro S. (2010) Phosphoinositides differentially regulate bacterial uptake and Nramp1-induced resistance to Legionella infection in Dictyostelium. Journal of cell science 123(Pt 23) 4039-51 [DOI  PMID]

Francione L, Smith PK, Accari SL, Taylor PE, Bokko PB, Bozzaro S, Beech PL, Fisher PR. (2009) Legionella pneumophila multiplication is enhanced by chronic AMPK signalling in mitochondrially diseased Dictyostelium cells. Disease models & mechanisms 2(9-10) 479-89 [DOI  PMID]

Bozzaro S, Bucci C, Steinert M. (2008) Phagocytosis and host-pathogen interactions in Dictyostelium with a look at macrophages. International review of cell and molecular biology 271 253-300 [DOI  PMID]

Colucci AM, Peracino B, Tala A, Bozzaro S, Alifano P, Bucci C. (2008) Dictyostelium discoideum as a model host for meningococcal pathogenesis. Medical science monitor : international medical journal of experimental and clinical research 14, BR134-40 [PMID]

Sillo A, Bloomfield G, Balest A, Balbo A, Pergolizzi B, Peracino B, Skelton J, Ivens A, Bozzaro S. (2008) Genome-wide transcriptional changes induced by phagocytosis or growth on bacteria in Dictyostelium. BMC genomics 9, 291 [DOI  PMID]

Galardi-Castilla M, Pergolizzi B, Bloomfield G, Skelton J, Ivens A, Kay RR, Bozzaro S, Sastre L. (2008) SrfB, a member of the Serum Response Factor family of transcription factors, regulates starvation response and early development in Dictyostelium. Developmental biology 316, 260-74 [DOI  PMID]

Balbo A, Bozzaro S (2008)
A novel biossay for evaluating soil bio-hazards using dictyostelium as biosensor: validation and application to the bio-bio project.
https://iris.unito.it/handle/2318/3794

Bozzaro S. (2006) Assaying cell-cell adhesion. Methods in molecular biology, 346 449-67 [DOI  PMID]

Balbo A, Bozzaro S. (2006) Cloning of Dictyostelium eIF6 (p27BBP) and mapping its nucle(ol)ar localization subdomains. European journal of cell biology 85, 1069-78 [DOI  PMID]

Muller-Taubenberger A, Bozzaro S. (2006) From cell-cell adhesion and cellular oscillations to spectacular views inside the cell--50 years of research with Dictyostelium. European journal of cell biology 85, 851-8 [DOI  PMID]

Peracino B, Wagner C, Balest A, Balbo A, Pergolizzi B, Noegel AA, Steinert M, Bozzaro S. (2006) Function and mechanism of action of Dictyostelium Nramp1 (Slc11a1) in bacterial infection. Traffic 7, 22-38 [DOI  PMID]

Arigoni M, Bracco E, Lusche DF, Kae H, Weeks G, Bozzaro S. (2005) A novel Dictyostelium RasGEF required for chemotaxis and development. BMC cell biology 6 43 [DOI  PMID]

Sultana H, Rivero F, Blau-Wasser R, Schwager S, Balbo A, Bozzaro S, Schleicher M, Noegel AA. (2005) Cyclase-associated protein is essential for the functioning of the endo-lysosomal system and provides a link to the actin cytoskeleton. Traffic, 6 930-46 [DOI  PMID]

Bozzaro S, Fisher PR, Loomis W, Satir P, Segall JE. (2004) Guenther Gerisch and Dictyostelium, the microbial model for ameboid motility and multicellular morphogenesis. Trends in cell biology 14, 585-8 [DOI  PMID]

Fajardo M, Schleicher M, Noegel A, Bozzaro S, Killinger S, Heuner K, Hacker J, Steinert M. (2004) Calnexin, calreticulin and cytoskeleton-associated proteins modulate uptake and growth of Legionella pneumophila in Dictyostelium discoideum. Microbiology  150, 2825-35 [DOI  PMID]

Queller DC, Ponte E, Bozzaro S, Strassmann JE. (2003) Single-gene greenbeard effects in the social amoeba Dictyostelium discoideum. Science  299, 105-6 [DOI  PMID]

 

Laboratory of Human and Medical Genetics

Redin, Claire, Brand, Harrison, Collins, Ryan L, Kammin, Tammy, Mitchell, Elyse, Hodge, Jennelle C, Hanscom, Carrie, Pillalamarri, Vamsee, Seabra, Catarina M, Abbott, Mary-Alice, Abdul-Rahman, Omar A, Aberg, Erika, Adley, Rhett, Alcaraz-Estrada, Sofia L, Alkuraya, Fowzan S, An, Yu, Anderson, Mary-Anne, Antolik, Caroline, Anyane-Yeboa, Kwame, Atkin, Joan F, Bartell, Tina, Bernstein, Jonathan A, Beyer, Elizabeth, Blumenthal, Ian, Bongers, Ernie M H F, Brilstra, Eva H, Brown, Chester W, Brüggenwirth, Hennie T, Callewaert, Bert, Chiang, Colby, Corning, Ken, Cox, Helen, Cuppen, Edwin, Currall, Benjamin B, Cushing, Tom, David, Dezso, Deardorff, Matthew A, Dheedene, Annelies, D', Hooghe, Marc, de Vries, Bert B A, Earl, Dawn L, Ferguson, Heather L, Fisher, Heather, Fitzpatrick, David R, Gerrol, Pamela, Giachino, Daniela, Glessner, Joseph T, Gliem, Troy, Grady, Margo, Graham, Brett H, Griffis, Cristin, Gripp, Karen W, Gropman, Andrea L, Hanson-Kahn, Andrea, Harris, David J, Hayden, Mark A, Hill, Rosamund, Hochstenbach, Ron, Hoffman, Jodi D, Hopkin, Robert J, Hubshman, Monika W, Innes, A Micheil, Irons, Mira, Irving, Melita, Jacobsen, Jessie C, Janssens, Sandra, Jewett, Tamison, Johnson, John P, Jongmans, Marjolijn C, Kahler, Stephen G, Koolen, David A, Korzelius, Jerome, Kroisel, Peter M, Lacassie, Yves, Lawless, William, Lemyre, Emmanuelle, Leppig, Kathleen, Levin, Alex V, Li, Haibo, Li, Hong, Liao, Eric C, Lim, Cynthia, Lose, Edward J, Lucente, Diane, Macera, Michael J, Manavalan, Poornima, Mandrile, Giorgia, Marcelis, Carlo L, Margolin, Lauren, Mason, Tamara, Masser-Frye, Diane, Mcclellan, Michael W, Mendoza, Cinthya J Zepeda, Menten, Björn, Middelkamp, Sjors, Mikami, Liya R, Moe, Emily, Mohammed, Shehla, Mononen, Tarja, Mortenson, Megan E, Moya, Graciela, Nieuwint, Aggie W, Ordulu, Zehra, Parkash, Sandhya, Pauker, Susan P, Pereira, Shahrin, Perrin, Danielle, Phelan, Katy, Aguilar, Raul E Piña, Poddighe, Pino J, Pregno, Giulia, Raskin, Salmo, Reis, Linda, Rhead, William, Rita, Debra, Renkens, Ivo, Roelens, Filip, Ruliera, Jayla, Rump, Patrick, Schilit, Samantha L P, Shaheen, Ranad, Sparkes, Rebecca, Spiegel, Erica, Stevens, Blair, Stone, Matthew R, Tagoe, Julia, Thakuria, Joseph V, van Bon, Bregje W, van de Kamp, Jiddeke, van Der Burgt, Ineke, van Essen, Ton, van Ravenswaaij-Arts, Conny M, van Roosmalen, Markus J, Vergult, Sarah, Volker-Touw, Catharina M L, Warburton, Dorothy P, Waterman, Matthew J, Wiley, Susan, Wilson, Anna, Yerena-de Vega, Maria de la Concepcion A, Zori, Roberto T, Levy, Brynn, Brunner, Han G, de Leeuw, Nicole, Kloosterman, Wigard P, Thorland, Erik C, Morton, Cynthia C, Gusella, James F, Talkowski, Michael E (2017)
The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies._Nat Genet. 2017 Jan;49(1):36-45. doi: 10.1038/ng.3720.

https://iris.unito.it/handle/2318/1631242

Turinetto, V, Orlando, L, Giachino, C (2017)
Induced Pluripotent Stem Cells: Advances in the Quest for Genetic Stability during Reprogramming Process._Int J Mol Sci. 2017 Sep 13;18(9). pii: E1952. doi: 10.3390/ijms18091952.
https://iris.unito.it/handle/2318/1647625

Turinetto, Valentina, Giachino, Claudia (2015)
Multiple facets of histone variant H2AX: a DNA double-strand-break marker with several biological functions._Nucleic Acids Res. 2015 Mar 11;43(5):2489-98. doi: 10.1093/nar/gkv061.
https://iris.unito.it/handle/2318/1521174

Cristallini C, Cibrario Rocchietti E, Accomasso L, Folino A, Gallina C, Muratori L, Pagliaro P, Rastaldo R, Raimondo S, Saviozzi S, Sprio AE, Gagliardi M, Barbani N, Giachino C (2014)
The effect of bioartificial constructs that mimic myocardial structure and biomechanical properties on stem cell commitment towards cardiac lineage. _Biomaterials. 2014 Jan;35(1):92-104. doi: 10.1016/j.biomaterials.2013.09.058.
https://iris.unito.it/handle/2318/139559

Ricci MT, Menegon S, Vatrano S, Mandrile G, Cerrato N, Carvalho P, De Marchi M, Gaita F, Giustetto C, Giachino DF (2014)
SCN1B gene variants in Brugada Syndrome: a study of 145 SCN5A-negative patients._Sci Rep. 2014 Sep 25;4:6470. doi: 10.1038/srep06470.
https://iris.unito.it/handle/2318/152953

Leonarduzzi Research Team

References

1. Gargiulo S, Sottero B, Gamba P, Chiarpotto E, Poli G, Leonarduzzi G. Plaque oxysterols induce imbalanced upregulation of matrix metalloproteinase-9 in macrophagic cells through redox-sensitive signaling pathways: Implications on the vulnerability of atherosclerotic lesions. Free Rad Biol Med, 51:844-855, 2011.

2. Gamba P, Leonarduzzi G, Tamagno E, Guglielmotto M, Testa G, Sottero B, Gargiulo S, Biasi F, Mauro A, Vina J, Poli G. Interaction between 24-hydroxycholesterol, oxidative stress and amyloid-β in amplifying neuronal damage in Alzheimer's disease: three partners in crime. Aging Cell, 10:403-17, 2011.

3. Gamba P, Guglielmotto M, Testa G, Monteleone D, Zerbinati C, Gargiulo S, Biasi F, Iuliano L, Giaccone G, Mauro A, Poli G, Tamagno E, Leonarduzzi G. Up-regulation of β-amyloidogenesis in neuron-like human cells by both 24- and 27-hydroxycholesterol: protective effect of N-acetylcysteine. Aging Cell, 13:561-572, 2014.

4. Gargiulo S, Gamba P, Testa G, Rossin D, Biasi F, Poli G, Leonarduzzi G. Relation between TLR4/NF-κB signaling pathway activation by 27-hydroxycholesterol and 4-hydroxynonenal, and atherosclerotic plaque instability. Aging Cell, 14:569-581, 2015.

5. Testa G, Staurenghi E, Zerbinati C, Gargiulo S, Iuliano L, Giaccone G,Fantò F, Poli G, Leonarduzzi G, Gamba P. Changes in brain oxysterols at different stages of Alzheimer's disease: Their involvement in neuroinflammation. Redox Biol, 10:24-33, 2016.

Maurizio Parola

Representative publications in the last years.

1. Novo E, Busletta C,  Valfrè di Bonzo L, Povero D,  Paternostro C, Mareschi K, Ferrero I, David E,  Bertolani C,  Caligiuri A,  Cannito S, Tamagno E,  Compagnone A, Colombatto S, Marra F, Fagioli F,  Pinzani M,  Parola M. Intracellular reactive oxygen species are required for directional migration of resident and bone marrow- derived profibrogenic cells. J Hepatol (2011), 54:964-974. (IF 2016:  12.486)

2. Locatelli I, Sutti S,  Jindal A, Vacchiano M, Bozzola C,   Reutelingsperger C, Kusters D, Benna S, Parola M,  Paternostro C,  Bugianesi E,   McArthur S, Albano E,  Perretti M.  The role of annexin A1 in modulating the progression of non-alcoholic steatohepatitis (NASH).  Hepatology (2014), 60:531-544.   (IF 2016: 13.246)

3. Cannito S, Turato C, Paternostro C, Biasiolo A, Colombatto S, Cambieri I, Quarta S, Novo E, Morello E, Villano G, Cillo U, Fasolato S, Musso T, David E, Tusa I, Rovida E, Autelli R, Smedile A, Cillo U, Pontisso P, Parola M. Hypoxia up-regulates SERPINB3 through HIF-2α in human liver cancer cells. Oncotarget (2015), 6:2206-2221.(IF 2016:  5.168)

4. Rovida E, Di Maira G, Tusa I, Cannito S, Paternostro C, Navari N, Vivoli E, Deng X, Gray NS, Esparís-Ogando A, David E, Pandiella A, Dello Sbarba P, Parola M, Marra F. The mitogen-activated protein kinase ERK5 regulates the development and growth of  hepatocellular carcinoma. Gut (2015) 64:1454-65. (IF 2016:16.658)

5. Cannito S, Novo E, Parola M. Therapeutic signaling pathways in fibroblasts.  Adv Drug Del Rev (2017), accepted on 26th May 2017.  Doi:10.1016/j.addr.2017.05.017 PMID: 28578015. (IF 2016:  11.764)

Obstructive Pulmonary Disease Group

Short list of publications: 

1)      Ricciardolo FLM, Sabatini F, Sorbello V, Benedetto S, Defilippi I, Petecchia L, Usai C, Gnemmi I, Balbi B, De Rose V, Ten Hacken NH, Postma DS, Timens W, Di Stefano A.Expression of vascular remodelling markers in relation to bradykinin receptors in asthma and COPD.

Thorax 2013; 68 (9):803-811. 

2)      Sorbello V, Ciprandi G, Di Stefano A, Massaglia GM, Favatà G, Conticello S, Malerba M, Folkerts G, Profita M, Rolla G, Ricciardolo FLM.

Nasal IL-17F is related to bronchial IL-17F/Neutrophilia and exacerbations in stable atopic severe asthma.

Allergy 2015; 70:236-240. 

3)      Ciprandi G, Schiavetti I, Rindone E, Ricciardolo FLM.

The impact of anxiety and depression on outpatients with asthma.

Ann Allergy Asthma Immunol 2015; 115(5):408-414. 

4)      Ricciardolo FLM, Sorbello V, Folino A, Gallo F, Massaglia GM, Favatà G, Conticello S, Vallese D, Gani F, Malerba M, Folkerts G, Rolla G, Profita M, Mauad T, Di Stefano A, Ciprandi G.

Identification of IL-17F/frequent exacerbatorendotype in asthma.

J Allergy ClinImmunol. 2017 Aug;140(2):395-406. 

5)      Di Stefano A, Ricciardolo FLM, Caramori G, Adcock IM, Chung KF, Barnes PJ, Brun P Leonardi A, Andò F, Vallese D, Gnemmi I, Righi L, Cappello F, Balbi B.

Bronchial inflammation and bacterial load in stable COPD is associated with TLR4 overexpression.

EurRespir J. 2017 May 23;49(5). pii: 1602006. doi: 10.1183/13993003.02006-2016.

 

Pathophysiology of inflammatory intestinal diseases

1: Sottero B, Rossin D, Poli G, Biasi F. Lipid Oxidation Products in the Pathogenesis of Inflammation-related Gut Diseases. Curr Med Chem. 2018;25(11):1311-1326. doi: 10.2174/0929867324666170619104105.

2: Rossin D, Calfapietra S, Sottero B, Poli G, Biasi F. HNE and cholesterol oxidation products in colorectal inflammation and carcinogenesis. Free Radic Biol Med. 2017 Oct;111:186-195. doi: 10.1016/j.freeradbiomed.2017.01.017.

3: Deiana M, Calfapietra S, Incani A, Atzeri A, Rossin D, Loi R, Sottero B, Iaia N, Poli G, Biasi F. Derangement of intestinal epithelial cell monolayer by dietary cholesterol oxidation products. Free Radic Biol Med. 2017 Dec;113:539-550. doi: 10.1016/j.freeradbiomed.2017.10.390.

4: Poli G, Biasi F. Potential modulation of cancer progression by oxysterols. Mol Aspects Med. 2016 Jun;49:47-8. doi: 10.1016/j.mam.2016.04.002.

5: Guina T, Deiana M, Calfapietra S, Cabboi B, Maina M, Tuberoso CI, Leonarduzzi G, Gamba P, Gargiulo S, Testa G, Poli G, Biasi F. The role of p38 MAPK in the induction of intestinal inflammation by dietary oxysterols: modulation by wine phenolics. Food Funct. 2015 Apr;6(4):1218-28. doi: 10.1039/c4fo01116c. 

6: Biasi F, Guina T, Maina M, Cabboi B, Deiana M, Tuberoso CI, Calfapietra S, Chiarpotto E, Sottero B, Gamba P, Gargiulo S, Brunetto V, Testa G, Dessì MA, Poli G, Leonarduzzi G. Phenolic compounds present in Sardinian wine extracts protect against the production of inflammatory cytokines induced by oxysterols in CaCo-2 human enterocyte-like cells. Biochem Pharmacol. 2013 Jul 1;86(1):138-45. doi: 10.1016/j.bcp.2013.03.024. 

7: Biasi F, Leonarduzzi G, Oteiza PI, Poli G. Inflammatory bowel disease: mechanisms, redox considerations, and therapeutic targets. Antioxid Redox Signal. 2013 Nov 10;19(14):1711-47. doi: 10.1089/ars.2012.4530. 

8: Biasi F, Guina T, Maina M, Nano M, Falcone A, Aroasio E, Saracco GM, Papotti M, Leonarduzzi G, Poli G. Progressive increase of matrix metalloprotease-9 and interleukin-8 serum levels during carcinogenic process in human colorectal tract. PLoS One. 2012;7(7):e41839. doi: 10.1371/journal.pone.0041839.

 

Sanità Pubblica, Epidemiologia e Biostatistica

5 recenti pubblicazioni del gruppo:

Stringhini S, Carmeli C, Jokela M, Avendaño M, Muennig P, Guida F, Ricceri F, d'Errico A, Barros H, Bochud M, Chadeau-Hyam M, Clavel-Chapelon F, Costa G, Delpierre C, Fraga S, Goldberg M, Giles GG, Krogh V, Kelly-Irving M, Layte R, Lasserre AM, Marmot MG, Preisig M, Shipley MJ, Vollenweider P, Zins M, Kawachi I, Steptoe A, Mackenbach JP, Vineis P, Kivimäki M; LIFEPATH consortium. Socioeconomic status and the 25X25 risk factors as determinants of premature mortality: a multicohort study and meta-analysis of 1·7 million men and women. Lancet. 2017 Mar 25;389(10075):1229-1237.

Mackenbach JP, Kulhánová I, Artnik B, Bopp M, Borrell C, Clemens T, Costa G, Dibben C, Kalediene R, Lundberg O, Martikainen P, Menvielle G, Östergren O, Prochorskas R, Rodríguez-Sanz M, Strand BH, Looman CW, de Gelder R. Changes in mortality inequalities over two decades: register based study of European countries. BMJ. 2016 Apr 11;353:i1732.

Vigna-Taglianti F, Burroni P, Mathis F, Versino E, Beccaria F, Rotelli M, Garneri M, Picciolini A, Bargagli AM, and the VEdeTTE Study Group. "Gender differences in heroin addiction and treatment: results from the VEdeTTE cohort". Substance Use Misuse 2016: 51(3): 295-309

Piccoli GB, Nazha M, Capizzi I, Vigotti FN, Scognamiglio S, Consiglio V, Mongilardi E, Bilocati M, Avagnina P, Versino E. Diet as a system: an observational study investigating a multi-choice system of moderately restricted low-protein diets. BMC Nephrol. 2016 Dec 7;17(1):197.

Berchialla P., Scarinzi, C., Snidero, S., Gregori, D. Comparing Models for Quantitative Risk Assessment: an Application to the European Registry of Foreign Body Injuries in Children. Statistical Methods in Medical Research 2016 Aug; 25(4):1244-59

Virginia De Rose

1) Crovella S, Segat L, Amato A, Athanasakis E, Bezzerri V, Braggion C, Casciaro R, Castaldo G, Colombo C, Covone AE, De Rose V, Gagliardini R, Lanzara C, Minicucci L, Morgutti M, Nicolis E, Pardo F, Quattrucci S, Raia V, Ravazzolo R, Seia M, Stanzial V, Termini L, Zazzeron L, Cabrini G, Gasparini P. A polymorphism in the 5' UTR of the DEFB1 gene is associated with the lung phenotype in F508del homozygous Italian cystic fibrosis patients. Clin Chem Lab Med 49:49-54. 2011.

2)  Ricciardolo FL, Sorbello V, Benedetto S, Defilippi I, Sabatini F, Robotti A, van Renswouw DC, Bucca C, Folkerts G, De Rose V. Bradykinin- and lipopolysaccharide-induced bradykinin B2 receptor expression, interleukin 8 release and "nitrosative stress" in bronchial epithelial cells BEAS-2B: role for neutrophils. Eur J Pharmacol. 694:30-8, 2012.

3)  Ricciardolo FL, Sabatini F, Sorbello V, Benedetto S, Defilippi I, Petecchia L, Usai C, Gnemmi I, Balbi B, De Rose V, Ten Hacken NH, Postma DS, Timens W, Di Stefano A. Expression of vascular remodelling markers in relation to bradykinin receptors in asthma and COPD. Thorax. 68:803-11, 2013.

4)  Bianchi ML, Colombo C, Assael BM, Dubini A, Lombardo M, Quattrucci S, Bella S, Collura M, Messore B, Raia V, Poli F, Bini R, Albanese CV, De Rose V, Costantini D, Romano G, Pustorino E, Magazzù G, Bertasi S, Lucidi V, Traverso G, Coruzzo A, Grzejdziak AD. Treatment of low bone density in young people with cystic fibrosis: a multicentre, prospective, open-label observational study of calcium and calcifediol followed by a randomised placebo-controlled trial of alendronate.  Lancet Respir Med.1:377-85, 2013.

5) Galluzzo M, Ciraolo E, Lucattelli M, HoxhaE, Ulrich M, Campa CC,  Lungarella G, Doring G, Zhou-Suckow Z, Mall  M, Hirsch E, and De Rose V.  Genetic Deletion and Pharmacological Inhibition of PI3Kγ Reduces Neutrophilic Ariway Inflammation and Lung Damage in Mice with Cystic Fibrosis-Like Lung Disease. "New developments in Cystic Fibrosis airway inflammation". Mediators of Inflammation, 2015: 545417. doi: 10.1155/2015/545417. Epub 2015 Jun 21.

 

Laboratorio di Fisiologia Cardiovascolare - Cardiovascular Physiology Laboratory

5 pubblicazioni più significative degli ultimi anni:

  1. Angotti C, Venier-Julienne MC, Penna C, Femminò S, Sindji L, Paniagua C, Montero-Menei CN, Pagliaro P. Nanoprecipitatedcatestatin released from pharmacologically active microcarriers (PAMs) exerts pro-survival effects on MSC. Int J Pharm. 2017 May 25;523(2):506-514. doi: 10.1016/j.ijpharm.2016.11.050.
  2. Folino A, Accomasso L, Giachino C, Montarolo PG, Losano G, Pagliaro P*, Rastaldo R*. Apelin-induced cardioprotection against ischaemia/reperfusion injury: roles of epidermal growth factor and Src. ActaPhysiol (Oxf). 2017 Jul 27. doi:10.1111/apha.12924. *Equal contribution.
  3. Mastrocola R, Collino M, Penna C, Nigro D, Chiazza F, Fracasso V, Tullio F, Alloatti G, Pagliaro P, Aragno M. Maladaptive Modulations of NLRP3 Inflammasome and cardioprotective Pathways Are Involved in Diet-Induced Exacerbation of Myocardial Ischemia/Reperfusion Injury in Mice. Oxid Med Cell Longev.2016;2016:3480637. doi: 10.1155/2016/3480637.
  4. Morano M, Angotti C, Tullio F, Gambarotta G, Penna C, Pagliaro P*, Geuna S. Myocardial ischemia/reperfusion upregulates the transcription of the Neuregulin1 receptor ErbB3, but only postconditioning preserves protein translation: Role in oxidative stress. Int J Cardiol. 2017 Apr 15;233:73-79. doi: 10.1016/j.ijcard.2017.01.122. *Corresponding author
  5. Penna C, Tullio F, Femminò S, Rocca C, Angelone T, Cerra MC, Gallo MP, Gesmundo I, Fanciulli A, Brizzi MF, Pagliaro P, Alloatti G, Granata R. Obestatin regulates cardiovascular function and promotes cardioprotection through the nitric oxide pathway. J Cell Mol Med. 2017 Jul 26. doi: 10.1111/jcmm.13277.

 

5 most significant publications of recent years:

  1. Angotti C, Venier-Julienne MC, Penna C, Femminò S, Sindji L, Paniagua C, Montero-Menei CN, Pagliaro P. Nanoprecipitatedcatestatin released from pharmacologically active microcarriers (PAMs) exerts pro-survival effects on MSC. Int J Pharm. 2017 May 25;523(2):506-514. doi: 10.1016/j.ijpharm.2016.11.050.
  2. Folino A, Accomasso L, Giachino C, Montarolo PG, Losano G, Pagliaro P*, Rastaldo R*. Apelin-induced cardioprotection against ischaemia/reperfusion injury: roles of epidermal growth factor and Src. ActaPhysiol (Oxf). 2017 Jul 27. doi:10.1111/apha.12924. *Equal contribution.
  3. Mastrocola R, Collino M, Penna C, Nigro D, Chiazza F, Fracasso V, Tullio F, Alloatti G, Pagliaro P, Aragno M. Maladaptive Modulations of NLRP3 Inflammasome and cardioprotective Pathways Are Involved in Diet-Induced Exacerbation of Myocardial Ischemia/Reperfusion Injury in Mice. Oxid Med Cell Longev.2016;2016:3480637. doi: 10.1155/2016/3480637.
  4. Morano M, Angotti C, Tullio F, Gambarotta G, Penna C, Pagliaro P*, Geuna S. Myocardial ischemia/reperfusion upregulates the transcription of the Neuregulin1 receptor ErbB3, but only postconditioning preserves protein translation: Role in oxidative stress. Int J Cardiol. 2017 Apr 15;233:73-79. doi: 10.1016/j.ijcard.2017.01.122. *Corresponding author
  5. Penna C, Tullio F, Femminò S, Rocca C, Angelone T, Cerra MC, Gallo MP, Gesmundo I, Fanciulli A, Brizzi MF, Pagliaro P, Alloatti G, Granata R. Obestatin regulates cardiovascular function and promotes cardioprotection through the nitric oxide pathway. J Cell Mol Med. 2017 Jul 26. doi: 10.1111/jcmm.13277.

Laboratory for Nutrition and Metabolic Disorders Research

Five selected publications of the last 5 years:

  1. Nigro D, Menotti F, Cento AS, Serpe L, Chiazza F, Dal Bello F, Romaniello F, Medana C, Collino M, Aragno M, Mastrocola R.Chronic administration of saturated fats and fructose differently affect SREBP activity resulting in different modulation of Nrf2 and Nlrp3 inflammasome pathways in mice liver.J NutrBiochem42:160-171, 2017. doi: 10.1016/j.jnutbio.2017.01.010
  2. Mastrocola R, Nigro D, Cento AS, Chiazza F, Collino M, Aragno M.High-fructose intake as risk factor for neurodegeneration: Key role for carboxymethyllysine accumulation in mice hippocampal neurons.Neurobiol Dis89:65-75, 2016. doi: 10.1016/j.nbd.2016.02.005
  3. Mastrocola R, Nigro D, Chiazza F, Medana C, Dal Bello F, Boccuzzi G, Collino M, Aragno M.Fructose-derived advanced glycation end-products drive lipogenesis and skeletal muscle reprogramming via SREBP-1c dysregulation in mice.Free RadicBiol Med91:224-35, 2016. doi: 10.1016/j.freeradbiomed.2015.12.022
  4. Chiazza F, Couturier-Maillard A, Benetti E, Mastrocola R, Nigro D, Cutrin JC, Serpe L, Aragno M, Fantozzi R, Ryffel B, Thiemermann C, Collino M. Targeting the NLRP3 inflammasome to reduce diet-induced metabolic abnormalities in mice.Mol Med 21:1025-1037, 2015. doi: 10.2119/molmed.2015.00104.
  5.  Mastrocola R, Collino M, Rogazzo M, Medana C, Nigro D, Boccuzzi G, Aragno M.Advanced glycation end products promote hepatosteatosis by interfering with SCAP-SREBP pathway in fructose-drinking mice.Am J PhysiolGastrointest Liver Physiol305(6):G398-407, 2013. doi: 10.1152/ajpgi.00450.2012

Laboratory of Human Anatomy

Ronchi G, Cillino M, Gambarotta G, Fornasari BE, Raimondo S, Pugliese P, Tos P, Cordova A, Moschella F, Geuna S. Irreversible changes occurring in long-term denervated Schwann cells affect delayed nerve repair. J Neurosurg. 2017 Oct;127(4):843-856. 

Mazzara PG, Massimino L, Pellegatta M, Ronchi G, Ricca A, Iannielli A, Giannelli SG, Cursi M, Cancellieri C, Sessa A, Del Carro U, Quattrini A, Geuna S, Gritti A, Taveggia C, Broccoli V. Two factor-based reprogramming of rodent and human fibroblasts into Schwann cells. Nat Commun. 2017 Feb 7;8:14088. 

Fregnan F, Ciglieri E, Tos P, Crosio A, Ciardelli G, Ruini F, Tonda-Turo C, Geuna S, Raimondo S. Chitosan crosslinked flat scaffolds for peripheral nerve regeneration. Biomed Mater. 2016 Aug 10;11(4):045010. 

Meyer C, Stenberg L, Gonzalez-Perez F, Wrobel S, Ronchi G, Udina E, Suganuma S, Geuna S, Navarro X, Dahlin LB, Grothe C, Haastert-Talini K. Chitosan-film enhanced chitosan nerve guides for long-distance regeneration of peripheral nerves. Biomaterials. 2016 Jan;76:33-51. 

Moimas S, Novati F, Ronchi G, Zacchigna S, Fregnan F, Zentilin L, Papa G, Giacca M, Geuna S, Perroteau I, Arnež ZM, Raimondo S. Effect of vascular endothelial growth factor gene therapy on post-traumatic peripheral nerve regeneration and denervation-related muscle atrophy. Gene Ther. 2013 Oct;20(10):1014-21.

Laboratory of Molecular Virology and Antiviral Research

Selected 5 publications (last 5years)

CagnoV, AndreozziP, D'AlicarnassoM,SilvaPJ, MuellerM,Galloux M, Dr. Le Goffic R, JonesST, VallinoM, HodekJ,WeberJ, SenS, JanečekMR, BekdemirA, SanavioB, MartinelliC, DonalisioM, Dr. Rameix-Welti MA, HanY, KaiserL, Vukovic L,TapparelC, KrálP, KrolS, LemboD*, StellacciF.* (2017). Broad-spectrum Non-toxic Antiviral Nanoparticles with a Virucidal Inhibition Mechanism. NATURE MATERIALS, 2017 accepted for publication (in press)

Donalisio M, Quaranta P, Chiuppesi F, Pistello M, Cagno V, Cavalli R, Volante M, Bugatti A, Rusnati M, Ranucci E, Ferruti P, Lembo D (2016). The AGMA1 poly(amidoamine) inhibits the infectivity of herpes simplex virus in cell lines, in human cervicovaginal histocultures, and in vaginally infected mice. BIOMATERIALS, vol. 85, p. 40-53.

Civra A, Giuffrida MG, Donalisio M, Napolitano L, Takada Y, Coulson BS, Conti A, Lembo D. (2015). Identification of Equine Lactadherin-derived Peptides That Inhibit Rotavirus Infection via Integrin Receptor Competition. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 290, p. 12403-14-12414.

Donalisio M, Massari S, Argenziano M, Manfroni G, Cagno V, Civra A, Sabatini S, Cecchetti V, Loregian A, Cavalli R, Lembo D*, Tabarrini O*. (2014). Ethyl 1,8-Naphthyridone-3-carboxylates Downregulate Human Papillomavirus-16 (HPV-16) E6 and E7 Oncogenes Expression. JOURNAL OF MEDICINAL CHEMISTRY, vol. 57, p. 5649-5663.

Civra A, Cagno V, Donalisio M, Biasi F, Leonarduzzi G, Poli G, Lembo D (2014). Inhibition of pathogenic non-enveloped viruses by 25-hydroxycholesterol and 27-hydroxycholesterol. SCIENTIFIC REPORTS, vol. 4, p. 7487-7493.

Laboratory of Pharmacology

5 most significant publications of recent years: 

  1. Berta GN, Sprio AE, Iezzi M, Spadaro M, Cappia S, Salamone P, Di Scipio F, Mognetti B, Papotti M, Musiani P, Forni G, Cavallo F. - "A DNA vaccine against ERBB2 impairs chemical carcinogenesis in random-bred hamsters" - Cancer Prev Res (Phila). 2011 Jul;4(7):994-1001 - PMID: 21733823 
  1. De Francia S, Massano D, Piccione FM, Pirro E, Racca S, Di Carlo F, Piga A. A new HPLC UV validated method for therapeutic monitoring of deferasirox in thalassaemic patients. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Apr 15;893-894:127-33.doi:  10.1016/j.jchromb.2012.02.047. PMID: 22436824. 
  1. Racca S, Piccione F, Spaccamiglio A, Carriero VM, De Francia S, Cangemi L, Esculapio P, Papotti M, Migliaretti G, Portaleone P, Di Carlo F, Abbadessa G. Effects of sub-chronic nandrolone administration on hormonal adaptive response to acute stress in rats. Psychoneuroendocrinology. 2012 Aug;37(8):1234-47. doi:10.1016/j.psyneuen.2011.12.017. PMID: 22226432. 
  1. Di Scipio F, Sprio AE, Folino A, Carere ME, Salamone P, Yang Z, Berrone M, Prat M, Losano G, Rastaldo R, Berta GN. - "Injured cardiomyocytes promote dental pulp mesenchymal stem cell homing" - BBA - General Subjects. 2014; 1840(7):2152-2161 - PMID: 24631652 
  1. Pergolizzi B, Carriero V, Abbadessa G, Penna C, Berchialla P, De Francia S, Bracco E, Racca S. Subchronic nandrolone administration reduces cardiac oxidative markers during restraint stress by modulating protein expression patterns. Mol Cell Biochem. 2017 Apr 21. doi: 10.1007/s11010-017-3036-7.

 

Reumatologia

Pubblicazioni
1) Sakellariou G, Conaghan PG, Zhang W, Bijlsma JWJ, Boyesen P, D'Agostino MA, Doherty M, Fodor D, Kloppenburg M, Miese F, Naredo E, Porcheret M, Iagnocco A. EULAR recommendations for the use of imaging in the clinical management of peripheral joint osteoarthritis. Ann Rheum Dis. 2017 Sep;76(9):1484-1494. doi: 10.1136/annrheumdis-2016-210815. Epub 2017 Apr 7.
2) Filippou G, Scirè CA, Damjanov N, Adinolfi A, Carrara G, Picerno V, Toscano C, Bruyn GA, D'Agostino MA, Delle Sedie A, Filippucci E, Gutierrez M, Micu M, Möller I, Naredo E, Pineda C, Porta F, Schmidt WA, Terslev L, Vlad V, Zufferey P, Iagnocco A. Definition and Reliability Assessment of Elementary Ultrasonographic Findings in Calcium Pyrophosphate Deposition Disease: A Study by the OMERACT Calcium Pyrophosphate Deposition Disease Ultrasound Subtask Force. J Rheumatol. 2017 Mar 1. pii: jrheum.161057. doi: 10.3899/jrheum.161057. [Epub ahead of print]
3) Bellis E, Scirè CA, Carrara G, Adinolfi A, Batticciotto A, Bortoluzzi A, Cagnotto G, Caprioli M, Canzoni M, Cavatorta FP, De Lucia O, Di Sabatino V, Draghessi A, Filippou G, Farina I, Focherini MC, Gabba A, Gutierrez M, Idolazzi L, Luccioli F, Macchioni P,
Massarotti MS, Mastaglio C, Menza L, Muratore M, Parisi S, Picerno V, Piga M, Ramonda R, Raffeiner B, Rossi D, Rossi S, Rossini P, Sakellariou G, Scioscia C, Venditti C, Volpe A, Matucci-Cerinic M, Iagnocco A. Ultrasound-detected tenosynovitis independently associates with patient-reported flare in patients with rheumatoid arthritis in clinical remission: results from the observational study STARTER of the Italian Society for Rheumatology. Rheumatology (Oxford). 2016 Oct;55(10):1826-36. doi: 10.1093/rheumatology/kew258. Epub 2016 Jun 27.
4) Iagnocco A, Finucci A, Ceccarelli F, Perricone C, Iorgoveanu V, Valesini G. Power Doppler ultrasound monitoring of response to anti-tumour necrosis factor alpha treatment in patients with rheumatoid arthritis. Rheumatology (Oxford). 2015 Oct;54(10):1890-6. doi: 10.1093/rheumatology/kev211. Epub 2015 Jun 11.
5) *Hammer HB, Iagnocco A, Mathiessen A, Filippucci E, Gandjbakhch F, Kortekaas MC, Möller I, Naredo E, Wakefield RJ, Aegerter P, D'Agostino MA. Global ultrasound assessment of structural lesions in osteoarthritis: a reliability study by the OMERACT ultrasonography group on scoring cartilage and osteophytes in finger joints. Ann Rheum Dis. 2016 Feb;75(2):402-7. doi: 10.1136/annrheumdis-2014-206289. Epub 2014 Dec 17.
*the 1st and 2nd authors contributed to the work equally

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