Dipartimento di Scienze Cliniche e Biologiche

Altered cholesterol metabolism in neurodegenerative diseases

Testa G, Staurenghi E, Zerbinati C, Gargiulo S, Iuliano L, Giaccone G, Fantò F, Poli G, Leonarduzzi G, Gamba P. Changes in brain oxysterols at different stages of Alzheimer’s disease: their involvement in neuroinflammation. Redox Biology 2016 10:24-33.

Testa G, Staurenghi E, Giannelli S, Gargiulo S, Guglielmotto M, Tabaton M, Tamagno E, Gamba P, Leonarduzzi G. A silver lining for 24-hydroxycholesterol in Alzheimer's disease: The involvement of the neuroprotective enzyme sirtuin 1. Redox Biol. 2018 17:423-431.

Staurenghi E, Cerrato V, Gamba P, Testa G, Giannelli S, Leoni V, Caccia C, Buffo A, Noble W, Perez-Nievas BG, Leonarduzzi G. Oxysterols present in Alzheimer's disease brain induce synaptotoxicity by activating astrocytes: A major role for lipocalin-2. Redox Biol. 2021 39:101837.

Staurenghi E, Leoni V, Lo Iacono M, Sottero B, Testa G, Giannelli S, Leonarduzzi G, Gamba P. ApoE3 vs. ApoE4 astrocytes: A detailed analysis provides new insights into differences in cholesterol homeostasis. Antioxidants (Basel) 2022 11(11):2168.

Testa G, Giannelli S, Sottero B, Staurenghi E, Giaccone G, Caroppo P, Gamba P, Leonarduzzi G. (2023). 24-Hydroxycholesterol Induces Tau Proteasome-Dependent Degradation via the SIRT1/PGC1/Nrf2 Pathway: A Potential Mechanism to Counteract Alzheimer’s Disease. Antioxidants 2023 12, 631.

Biologia Applicata

Pubblicazioni su riviste internazionali: 5 recenti prodotti rappresentativi

• Perrelli A, Retta SF. (2023). Identification of galectin-3 as a novel potential prognostic/predictive biomarker and therapeutic target for cerebral cavernous malformation disease. Genes & Diseases. 2023 Apr 3;11(1):67-71. doi: 10.1016/j.gendis.2023.02.045.
• Perrelli A, Ferraris C, Berni E, Glading AJ, Retta SF. (2023). KRIT1: A Traffic Warden at the Busy Crossroads Between Redox Signaling and the Pathogenesis of Cerebral Cavernous Malformation Disease. Antioxidants & Redox Signaling. 2023 Mar;38(7-9):496-528. doi: 10.1089/ars.2021.0263. Epub 2022 Nov 1.
• Perrelli A, Retta SF. (2021). Polymorphisms in genes related to oxidative stress and inflammation: Emerging links with the pathogenesis and severity of Cerebral Cavernous Malformation disease. Free Radical Biology and Medicine. 2021 August 20;172:403-417. DOI: 10.1016/j.freeradbiomed.2021.06.021.
• De Luca E, Perrelli A, Swamy H, Nitti M, Passalacqua M, Furfaro AL, Salzano AM, Scaloni A, Glading AJ, Retta SF. (2021). Protein kinase Cα regulates the nucleocytoplasmic shuttling of KRIT1. Journal of Cell Science. 2021 Feb 4;134(3):jcs250217. DOI: 10.1242/jcs.250217.
• Perrelli A, Fatehbasharzad P, Benedetti V, Ferraris C, Fontanella M, De Luca E, Moglianetti M, Battaglia L, Retta SF. (2021). Towards precision nanomedicine for cerebrovascular diseases with emphasis on Cerebral Cavernous Malformation (CCM). Expert Opinion on Drug Delivery. 2021 Jan 23;18(7):849-876. DOI: 10.1080/17425247.2021.1873273.

Pubblicazioni su riviste internazionali: link ai database PubMed e Scopus

• PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Retta+SF&sort=date
• Scopus: https://www.scopus.com/authid/detail.uri?authorId=6603604351

 

Biostatistica

• Berchialla, P., Sciannameo, V., Urru, S., Lanera, C., Azzolina, D., Gregori, D., & Baldi, I. (2021). Adjustment for baseline covariates to increase efficiency in RCTs with binary endpoint: A comparison of Bayesian and frequentist approaches. International Journal of Environmental Research and Public Health, 18(15). https://doi.org/10.3390/ijerph18157758
• Sciannameo, V., Berchialla, P., Avogaro, A., Fadini, G. P., & Network, D.‑ (2021). Transposition of cardiovascular outcome trial effects to the real‑world population of patients with type 2 diabetes. Cardiovascular Diabetology, 20(1), 103. https://doi.org/10.1186/s12933-021-01300-y
• Berchialla, P., Chiffi, D., Valente, G., & Voutilainen, A. (2021). The power of meta‑analysis: A challenge for evidence‑based medicine. European Journal for Philosophy of Science, 11(1). https://doi.org/10.1007/s13194-020-00321-w
• Berchialla, P., Zohar, S., & Baldi, I. (2019). Bayesian sample size determination for phase IIA clinical trials using historical data and semi‑parametric prior’s elicitation. Pharmaceutical Statistics, 18(2), 198–211 https://doi.org/10.1002/pst.1914
• Lanera, C., Berchialla, P., Sharma, A., Minto, C., Gregori, D., & Baldi, I. (2019). Screening PubMed abstracts: Is class imbalance always a challenge to machine learning? Systematic Reviews, 8(1). https://doi.org/10.1186/s13643-019-1245-8

Cancer cachexia

PUBLICATIONS

• Pin, M. Beltrà, L. García-Castillo, B. Pardini, G. Birolo, G. Matullo, F. Penna, D. Guttridge, P. Costelli (2022). Extracellular vesicles derived from tumor cells as a trigger of energy default in the skeletal muscle. Journal of Cachexia, Sarcopenia and Muscle, 10.1002/jcsm.12844, in press.
• Sartori, A. Hagg, S. Zampieri, A. Armani, C.E. Winbanks, L.R. Viana, M. Haidar , K.I. Watt, H. Qian, C. Pezzini, P. Zanganeh, B.J. Turner, A. Larsson, G. Zanchettin, E.S. Pierobon, L. Moletta, M. Valmasoni, A. Ponzoni, S. Attar, G. DaDalt, C. Sperti, M. Kustermann, R.E. Thomson, L. Larsson, K.L. Loveland, P. Costelli, A. Megighian, S. Merigliano, F. Penna, P. Gregorevic, M.Sandri (2021). Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia. Science Translational Medicine, 4;13(605):eaay9592.
• Costamagna, R. Duelen, F. Penna, D. Neumann, P. Costelli, M. Sampaolesi (2020). Interleukin 4 administration improves muscle function, adult myogenesis and lifespan of colon carcinoma-bearing mice. Journal of Cachexia, Sarcopenia and Muscle, 11: 783-801.
• Penna, R. Ballarò, P. Martinez-Cristobal, D. Sala, D. Sebastian, S. Busquets, M. Muscaritoli, JM Argilés, P. Costelli, A. Zorzano (2019). Autophagy exacerbates muscle wasting in cancer cachexia and impairs mitochondrial function. J. Mol. Biol., 431: 2674-2686.
• Ballarò, M. Beltrà, S. De Lucia, F. Pin, K. Ranjbar, J.J. Hulmi, P. Costelli, F. Penna (2019). Moderate exercise in mice improves cancer plus chemotherapy-induced muscle wasting and mitochondrial alterations. FASEB J., 33: 5482-5494.

Embodied Minds

• Ghelli, F; Malandrone, F; Bellisario, V; Squillacioti, G; Panizzolo, M; Colombi, N; Ostacoli, L; Bono, R. The Quality of Life and the Bio-Molecular Profile in Working Environment: A Systematic Review, 2022. SUSTAINABILITY, 10.3390/su14138100
• Ferrante G.; Rossini P.G.; Rousset S.; Ostacoli L.; Piccinelli C.; Carletto S.; Giordano L.. The emotional side of post-traumatic stress reaction during COVID-19 pandemic: an Italian survey, 2022. BMC PUBLIC HEALTH, 10.1186/s12889-022-12749-1
• Sara Carletto; Maria Chiara Ariotti; Giulia Garelli; Ludovica Di Noto; Paola Berchialla; Francesca Malandrone; Roberta Guardione; Floriana Boarino; Maria Francesca Campagnoli; Patrizia Savant Levet; Enrico Bertino; Luca Ostacoli; Alessandra Coscia. Moral Distress and Burnout in Neonatal Intensive Care Unit Healthcare Providers: A Cross-Sectional Study in Italy, 2022. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 10.3390/ijerph19148526
• Petros, Nuhamin Gebrewold; Hadlaczky, Gergo; Carletto, Sara; Martinez, Sergio Gonzalez; Ostacoli, Luca; Ottaviano, Manuel; Meyer, Björn; Scilingo, Enzo Pasquale; Carli, Vladimir. Sociodemographic Characteristics Associated With an eHealth System Designed to Reduce Depressive Symptoms Among Patients With Breast or Prostate Cancer: Prospective Study, 2022. JMIR FORMATIVE RESEARCH, 10.2196/33734
• Malandrone, Francesca; Catalano, Alberto; Carfì, Federica; Gentili, Claudio; Bianchi, Silvia; Oliva, Francesco; Ricceri, Fulvio; Ostacoli, Luca; Kesebir, Pelin; Davidson, Richard J; Carletto, Sara. Psychometric validation of the Italian version of the Emotional Style Questionnaire, 2022. PLOS ONE, 10.1371/journal.pone.0278715
• Carli, Vladimir; Petros, Nuhamin Gebrewold; Hadlaczky, Gergö; Vitcheva, Tereza; Berchialla, Paola; Bianchi, Silvia; Carletto, Sara; Christinaki, Eirini; Citi, Luca; Dinis, Sérgio; Gentili, Claudio; Geraldes, Vera; Giovinazzo, Lorena; Gonzalez-Martinez, Sergio; Meyer, Björn; Ostacoli, Luca; Ottaviano, Manuel; Ouakinin, Silvia; Papastylianou, Tasos; Paradiso, Rita; Poli, Riccardo; Rocha, Isabel; Settanta, Carmen; Scilingo, Enzo Pasquale; Valenza, Gaetano. The NEVERMIND e-health system in the treatment of depressive symptoms among patients with severe somatic conditions: A multicentre, pragmatic randomised controlled trial, 2022. ECLINICALMEDICINE, 10.1016/j.eclinm.2022.101423
• Portigliatti Pomeri, Alberto; La Salvia, Anna; Carletto, Sara; Oliva, Francesco; Ostacoli, Luca. EMDR in Cancer Patients: A Systematic Review, 2021. FRONTIERS IN PSYCHOLOGY, 10.3389/fpsyg.2020.590204
• Foletti, A; Baron, P; Berchialla, P; Francone, D; Malandrone, F; Ostacoli, L; Carletto, S. Use of biophysical treatment for the management of mild anxiety, depression and stress: a randomized controlled trial, 2020. JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS, 10.23812/20-132-L-57
• Ostacoli, Luca; Cosma, Stefano; Bevilacqua, Federica; Berchialla, Paola; Bovetti, Marialuisa; Carosso, Andrea Roberto; Malandrone, Francesca; Carletto, Sara; Benedetto, Chiara. Psychosocial factors associated with postpartum psychological distress during the Covid-19 pandemic: a cross-sectional study, 2020. BMC PREGNANCY AND CHILDBIRTH, 10.1186/s12884-020-03399-5
• Carli, Vladimir; Wasserman, Danuta; Hadlaczky, Gergö; Petros, Nuhamin Gebrewold; Carletto, Sara; Citi, Luca; Dinis, Sergio; Gentili, Claudio; Gonzalez-Martinez, Sergio; Aldo De Leonibus, null; Meyer, Björn; Ostacoli, Luca; Ottaviano, Manuel; Ouakinin, Silvia; Paradiso, Rita; Poli, Riccardo; Rocha, Isabel; Settanta, Carmen; Waldmeyer, Maria Teresa Arredondo; Valenza, Gaetano; Scilingo, Enzo Pasquale. A protocol for a multicentre, parallel-group, pragmatic randomised controlled trial to evaluate the NEVERMIND system in preventing and treating depression in patients with severe somatic conditions, 2020. BMC PSYCHIATRY, 10.1186/s12888-020-02494-3
• Eirini Christinaki, Tasos Papastylianou, Sara Carletto, Sergio Gonzalez-Martinez, Luca Ostacoli, Manuel Ottaviano, Riccardo Poli, Luca Citi. Well-being Forecasting using a ParametricTransfer-Learning method based on the FisherDivergence and Hamiltonian Monte Carlo, 2020. EAI ENDORSED TRANSACTIONS ON BIOENGINEERING AND BIOINFORMATICS., 10.4108/eai.16-10-2020.16666
• "Sara Carletto, Camillo Porcaro, Carmen Settanta, Vincenzo Vizzari, Maria Rosa Stanizzo, Francesco Oliva, Riccardo Torta, Isabel Fernandez, Mario Coletti Moja, Marco Pagani, Luca Ostacoli. Neurobiological Features and Response to Eye Movement Desensitization and Reprocessing Treatment of Post-traumatic Stress Disorder in Patients with Breast Cancer, 2019. EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY, 10.1080/20008198.2019.1600832"
• Malandrone, Francesca; Carletto, Sara; Hase, Michael; Hofmann, Arne; Ostacoli, Luca. A Brief Narrative Summary of Randomized Controlled Trials Investigating EMDR Treatment of Patients With Depression, 2019. JOURNAL OF EMDR PRACTICE AND RESEARCH, 10.1891/1933-3196.13.4.302
• Oliva F; Ostacoli L; Versino E; Portigliatti Pomeri A; Furlan PM; Carletto S; Picci RL.. Compulsory Psychiatric Admissions in an Italian Urban Setting: Are They Actually Compliant to the Need for Treatment Criteria or Arranged for Dangerous Not Clinical Condition?., 2019. FRONTIERS IN PSYCHIATRY, 10.3389/fpsyt.2018.00740
• Luca, Ostacoli; Sara, Carletto; Marco, Cavallo; Paula, Baldomir-Gago; Giorgio Di Lorenzo, ; Fernandez, Isabel; Michael, Hase; Ania, Justo-Alonso; Maria, Lehnung; Giuseppe, Migliaretti; Francesco, Oliva; Marco, Pagani; Susana, Recarey-Eiris; Riccardo, Torta; Visal, Tumani; Ana Isabel González-Vázquez, ; Arne, Hofmann. Comparison of Eye Movement Desensitization Reprocessing and Cognitive Behavioral Therapy as adjunctive treatments for recurrent depression: the European Depression EMDR Network (EDEN) randomized controlled trial., 2018. FRONTIERS IN PSYCHOLOGY, 10.3389/fpsyg.2018.00074
• Sara, Carletto; Martina, Borghi; Francesco, Scavelli; Diana, Francone; Maria Luisa Perucchini, ; Marco, Cavallo; Francesco, Pagnini; Antonio, Bertolotto; Francesco, Oliva; Luca, Ostacoli. Prevalence of Posttraumatic Stress Disorder in Patients With Multiple Sclerosis, 2018. JOURNAL OF NERVOUS AND MENTAL DISEASE, 10.1097/NMD.0000000000000780
• Oliva, Francesco; Nibbio, Gabriele; Vizzuso, Paola; Jaretti Sodano, Alessandro; Ostacoli, Luca; Carletto, Sara; Picci, Rocco Luigi. Gender Differences in Anxiety and Depression before and after Alcohol Detoxification: Anxiety and Depression as Gender-Related Predictors of Relapse, 2018. EUROPEAN ADDICTION RESEARCH, 10.1159/000490046
• Hase, Michael*; Plagge, Jens; Hase, Adrian; Braas, Roger; Ostacoli, Luca; Hofmann, Arne; Huchzermeier, Christian. Eye movement desensitization and reprocessing versus treatment as usual in the treatment of depression: A randomized-controlled trial, 2018. FRONTIERS IN PSYCHOLOGY, 10.3389/fpsyg.2018.01384
• Sara, Carletto; Francesco, Oliva; Micaela, Barnato; Teresa, Antonelli; Antonina, Cardia; Paolo, Mazzaferro; Raho, Carolina; Luca, Ostacoli; Fernandez, Isabel; Marco, Pagani. EMDR as Add-on Treatment for Psychiatric and Traumatic Symptoms in Patients with Substance Use Disorder., 2018. FRONTIERS IN PSYCHOLOGY, 10.3389/fpsyg.2017.02333
• Pacchiana, Mv; Capelletto, E; Carnio, S; Gridelli, C; Rossi, A; Galetta, D; Montagna, Es; Bordi, P; Ceribelli, A; Cortinovis, D; Scotti, V; Martelli, O; Valmadre, G; Del Conte, A; Miccianza, A; Morena, R; Rosetti, F; Di Maio, M; Ostacoli, L; Novello, S. Patients' Attitudes and Physicians' Perceptions Toward Maintenance Therapy for Advanced Non-Small-cell Lung Cancer: A Multicenter Italian Survey., 2017. CLINICAL LUNG CANCER, 10.1016/j.cllc.2016.10.002
• Carletto, Sara; Ostacoli, Luca; Colombi, Nicoletta; Luca, Calorio; Oliva, Francesco; Isabel, Fernandez; Arne, Hofmann. EMDR for Depression: a systematic review of controlled studies, 2017. CLINICAL NEUROPSYCHIATRY,
• Michael, Hase; Balmaceda, Ute M.; Luca, Ostacoli; Peter, Liebermann; Arne, Hofmann. The AIP Model of EMDR Therapy and Pathogenic Memories, 2017. FRONTIERS IN PSYCHOLOGY, 10.3389/fpsyg.2017.01578
• Carletto, Sara; Tesio, Valentina; Borghi, Martina; Francone, DIANA MARIA; Scavelli, Francesco; Bertino, Gabriella; Malucchi, Simona; Bertolotto, Antonio; Oliva, Francesco; Torta, Riccardo; Ostacoli, Luca. The Effectiveness of a Body-Affective Mindfulness Intervention for Multiple Sclerosis Patients with Depressive Symptoms: a Randomized Controlled Clinical Trial, 2017. FRONTIERS IN PSYCHOLOGY, 10.3389/fpsyg.2017.02083
• Sara Carletto1, 2*; Borghi, Martina; Bertino, Gabriella; Oliva, Francesco; Cavallo, Marco; Hofmann, Arne; Zennaro, Alessandro; Simona, Malucchi; Luca, Ostacoli. Treating Post-traumatic Stress Disorder in Patients with Multiple Sclerosis: A Randomized Controlled Trial Comparing the Efficacy of Eye Movement Desensitization and Reprocessing and Relaxation Therapy, 2016. FRONTIERS IN PSYCHOLOGY, 10.3389/fpsyg.2016.00526
• Oliva, Francesco; Versino, Elisabetta; Gammino, Lorenzo; Colombi, Nicoletta; Ostacoli, Luca; Carletto, Sara; Furlan, Piermaria; Picci, Rocco Luigi. Type D personality and essential hypertension in primary care. a cross-sectional observational study within a cohort of patients visiting general practitioners., 2016. JOURNAL OF NERVOUS AND MENTAL DISEASE, 10.1097/NMD.0000000000000421
• Borghi, Martina; Carletto, Sara; Ostacoli, Luca; Scavelli, Francesco; Pia, Lorenzo; Pagani, Marco; Bertolotto, Antonio; Malucchi, Simona; Signori, Alessio; Cavallo, Marco. Decline of Neuropsychological Abilities in a Large Sample of Patients with Multiple Sclerosis: A Two-Year Longitudinal Study, 2016. FRONTIERS IN HUMAN NEUROSCIENCE, 10.3389/fnhum.2016.00282
• Carletto, Sara; Borghi, Martina; Francone, Diana; Scavelli, Francesco; Bertino, Gabriella; Cavallo, Marco; Malucchi, Simona; Bertolotto, Antonio; Oliva, Francesco; Ostacoli, Luca. The efficacy of a Mindfulness Based Intervention for depressive symptoms in patients with Multiple Sclerosis and their caregivers: study protocol for a randomized controlled clinical trial., 2016. BMC NEUROLOGY, 10.1186/s12883-016-0528-0
• Picci RL; Oliva F; Trivelli F; Carezana C; Zuffranieri M; Ostacoli L; Furlan PM; Lala R. Emotional Burden and Coping Strategies of Parents of Children with Rare Diseases, 2015. JOURNAL OF CHILD AND FAMILY STUDIES, 10.1007/s10826-013-9864-5
• Ostacoli L; Saini A; Zuffranieri M; Boglione A; Carletto S; De Marco I; Lombardi I; Picci RL; Berruti A; Comandone A. Quality of Life, Anxiety and Depression in Soft Tissue Sarcomas as Compared to More Common Tumours: An Observational Study, 2014. APPLIED RESEARCH IN QUALITY OF LIFE, 10.1007/s11482-013-9213-2
• Picci RL; Oliva F; Zuffranieri M; Vizzuso P; Ostacoli L; Sodano AJ; Furlan PM. Quality of life, alcohol detoxification and relapse: Is quality of life a predictor of relapse or only a secondary outcome measure?, 2014. QUALITY OF LIFE RESEARCH, 10.1007/s11136-014-0735-3
• Hofmann, Arne; Hilgers, Angelika; Lehnung, Maria; Liebermann, Peter; Ostacoli, Luca; Schneider, Wolfgang; Hase, Michael. Eye Movement Desensitization and Reprocessing as an Adjunctive Treatment of Unipolar Depression: A Controlled Study, 2014. JOURNAL OF EMDR PRACTICE AND RESEARCH, 10.1891/1933-3196.8.3.103
• Cavallo M; Cavanna AE; Harciarek M; Johnston H; Ostacoli L; Angilletta C.. "Keep up the good work!": A case study of the effects of a specific cognitive training in Alzheimer's disease., 2013. NEUROCASE, 10.1080/13554794.2012.701643
• Grassi L; Johansen C; Annunziata MA; Capovilla E; Costantini A; Gritti P; Torta R; Bellani M; Italian Society of Psycho-Oncology Distress Thermometer Study Group.. Screening for distress in cancer patients: a multicenter, nationwide study in Italy., 2013. CANCER, 10.1002/cncr.27902
• Cavallo M; Trivelli F; Adenzato M; Bidoia E; Giaretto RM; Oliva F; Ostacoli L; Sala A; Picci RL. DO NEUROPSYCHOLOGICAL AND SOCIAL COGNITION ABILITIES IN SCHIZOPHRENIA CHANGE AFTER INTENSIVE COGNITIVE TRAINING? A PILOT STUDY, 2013. CLINICAL NEUROPSYCHIATRY,
• Capezzani L.; Ostacoli L.; Cavallo M.; Carletto S.; Fernandez I.; Solomon R.; Pagani M.; Cantelmi T.. EMDR and CBT for cancer patients: Comparative study of effects on PTSD, anxiety and depression, 2013. JOURNAL OF EMDR PRACTICE AND RESEARCH, 10.1891/1933-3196.7.3.134
• Picci RL; Versino E; Oliva F; Giaretto RM; Ostacoli L; Trivelli F; Venturello S; Furlan PM. Does substance use disorder affect clinical expression in first-hospitalization patients with schizophrenia? Analysis of a prospective cohort, 2013. PSYCHIATRY RESEARCH, 10.1016/j.psychres.2013.08.043
• Saini A; Berruti A; Cracco C; Sguazzotti E; Porpiglia F; Russo L; Bertaglia V; Picci RL; Negro M; Tosco A; Campagna S; Scarpa RM; Dogliotti L; Furlan PM; Ostacoli L.. Psychological distress in men with prostate cancer receiving adjuvant androgen-deprivation therapy., 2013. UROLOGIC ONCOLOGY, 10.1016/j.urolonc.2011.02.005
• Borghi M; Cavallo M; Carletto S; Ostacoli L; Zuffranieri M; Picci RL; Scavelli F; Johnston H; Furlan PM; Bertolotto A; Malucchi S.. Presence and significant determinants of cognitive impairment in a large sample of patients with multiple sclerosis., 2013. PLOS ONE, 10.1371/journal.pone.0069820
• Saini A; Berruti A; Ferini-Strambi L; Castronovo V; Rametti E; Giuliano PL; Ramassotto B; Picci RL; Negro M; Campagna S; Furlan PM; Ostacoli L. Restless Legs Syndrome as a Cause of Sleep Disturbances in Cancer Patients Receiving Chemotherapy, 2013. JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 10.1016/j.jpainsymman.2012.06.018
• Ostacoli L; Carletto S; Borghi M; Cavallo M; Rocci E; Zuffranieri M; Malucchi S; Bertolotto A; Zennaro A; Furlan PM; Picci RL. Prevalence and Significant Determinants of Post-traumatic Stress Disorder in a Large Sample of Patients with Multiple Sclerosis, 2013. JOURNAL OF CLINICAL PSYCHOLOGY IN MEDICAL SETTINGS, 10.1007/s10880-012-9323-2
• Ostacoli;M.  Zuffranieri;M.  Cavallo;A.  Zennaro;I.  Rainero;L.  Pinessi;M. V.  Pacchiana Parravicini;E.  Ladisa;P. M.  Furlan;R. L.  Picci. Age of Onset of Mood Disorders and Complexity of Personality Traits, 2013. ISRN PSYCHIATRY, 10.1155/2013/246358
• Picci RL; Vigna-Taglianti F; Oliva F; Mathis F; Salmaso S; Ostacoli L; Sodano AJ; Furlan PM. Personality disorders among patients accessing alcohol detoxification treatment: prevalence and gender differences, 2012. COMPREHENSIVE PSYCHIATRY, 10.1016/j.comppsych.2011.05.011
• Rainero I; Ostacoli L; Rubino E; Gallone S; Picci RL; Fenoglio P; Negro E; Rosso C; De Martino P; De Marchi M; Furlan PM; Pinessi L. Association between Major Mood Disorders and the hypocretin receptor 1 gene, 2011. JOURNAL OF AFFECTIVE DISORDERS, 10.1016/j.jad.2010.10.033
• Rainero I; Rubino E; Gallone S; Fenoglio P; Picci RL; Giobbe L; Ostacoli L; Pinessi L.. Evidence for an association between migraine and the hypocretin receptor 1 gene, 2011. THE JOURNAL OF HEADACHE AND PAIN, 10.1007/s10194-011-0314-8
• Saini A; Berruti A; Capogna S; Negro M; Sguazzotti E; Picci RL; Campagna S; Dongiovanni V; Dogliotti L; Furlan PM; Ostacoli L.. Prevalence of complementary/alternative medicines (CAMs) in a cancer population in northern Italy receiving antineoplastic treatments and relationship with quality of life and psychometric features., 2011. QUALITY OF LIFE RESEARCH, 10.1007/s11136-010-9795-1
• Tagliabue M; Gottero C; Zuffranieri M; Negro M; Carletto S; Picci RL; Tomelini M; Bertaina S; Pucci E; Trento M; Ostacoli L.. Sexual function in women with type 1 diabetes matched with a control group: depressive and psychosocial aspects, 2011. JOURNAL OF SEXUAL MEDICINE, 10.1111/j.1743-6109.2011.02262.x
• Ostacoli L; Saini A; Berruti A; Rametti E; Dogliotti L; Picci RL; Furlan PM. Distúrbio Pós-Traumático de Stress, qualidade do sono, ansiedade, depressão e qualidade de vida em pacientes oncológicos em tratamento quimioterápico, 2011. JOURNAL OF NURSING AND HEALTH,
• Ostacoli L; Cavallo M; Zuffranieri M; Negro M; Sguazzotti E; Picci RL; Tempia P; La Ciura P; Furlan PM. Comparison of experienced burnout symptoms in specialist oncology nurses working in hospital oncology units or in hospices., 2010. PALLIATIVE & SUPPORTIVE CARE, 10.1017/S1478951510000295
• Aluffi G; Zuffranieri M; Amistà E; Furlan PM; Ostacoli L; Picci RL. [Adults foster family care in Italian mental health services: a survey]., 2010. EPIDEMIOLOGIA E PSICHIATRIA SOCIALE,
• Ostacoli L; Saini A; Ferini-Strambi L; Castronovo V; Sguazzotti E; Picci RL; Toje M; Gorzegno G; Capogna S; Dongiovanni V; Dogliotti L; Furlan PM; Berruti A. Restless legs syndrome and its relationship with anxiety, depression, and quality of life in cancer patients undergoing chemotherapy, 2010. QUALITY OF LIFE RESEARCH, 10.1007/s11136-010-9614-8
• Furlan PM; Zuffranieri M; Stanga F; Ostacoli L; Patta J; Picci RL. Four-year follow-up of long-stay patients settled in the community after closure of Italy's psychiatric hospitals., 2009. PSYCHIATRIC SERVICES, 10.1176/appi.ps.60.9.1198
• Saini A; Ostacoli L; Gorzegno G; Picci RL; Dogliotti L; Furlan PM; Berruti A.. Risk of depressive events in long-term surviving patients affected by hormone-related cancer according to time after diagnosis, 2009. JOURNAL OF CLINICAL ONCOLOGY, 10.1200/JCO.2009.23.5663
• OSTACOLI L; COSTANTINI M; BECCARO M; DELLAI M; GORZEGNO G; PICCI RL; SGUAZZOTTI E; BERRUTI A; TORTA R; FURLAN PM. Development and validation of a patient-physician relationship index in the advanced cancer setting, 2007. TUMORI, 10.1700/304.3605
• ROSSO C; RAMBAUDI A; OSTACOLI L; GAROMBO M; FURLAN PM. Anoressia e bulimia: la sessualità nei disturbi della condotta alimentare conclamati e sottosoglia, 2006. QUADERNI ITALIANI DI PSICHIATRIA,
• REBAUDENGO N; RAINERO I; PARZIALE A; ROSINA F; PAVANELLI E; RUBINO E; MAZZA C; OSTACOLI L; FURLAN PM. Lack of interaction between a polymorphism in the dopamine D2 receptor gene and the clinical features of migraine, 2004. CEPHALALGIA, 10.1111/j.1468-2982.2004.00689.x
• Rosso C; Garbolino S; Ostacoli L; Furlan PM. Psychosexual problems in patients with neoplasms, 1999. ARCHIVIO ITALIANO DI UROLOGIA ANDROLOGIA,
• Rosso C; Ostacoli L; Garbolino S; Furlan PM.. The "small penis": considerations about subjective penile deficiency, 1998. ARCHIVIO ITALIANO DI UROLOGIA ANDROLOGIA,
• ROSSO C ;GARBOLINO S ;OSTACOLI L ;ROLLE L ;FONTANA D ;FURLAN PM. [Psychosexual interventions combined with biologic therapy of erectile dysfunction], 1995. ARCHIVIO ITALIANO DI UROLOGIA ANDROLOGIA,

Endocrinology

Giordano. Should all patients with adrenal insufficiency or a subgroup of patients with prediabetes be treated with dual-release hydrocortisone? Clin Endocrinol. 2018;89:297-298.

Parasiliti-Caprino, B. Lucatello, C. Lopez, J. Burrello, F. Maletta, M. Mistrangelo, E. Migliore, F. Tassone, A La Grotta, A. Pia, G. Reimondo, R. Giordano, G. Giraudo, A. Piovesan, G. Ciccone, D. Deandreis, P. Limone, F. Orlandi, G. Borretta, M. Volante, P. Mulatero, M. Papotti, G. Aimaretti, M. Terzolo, M. Morino, B. Pasini, F. Veglio, E. Ghigo, E. Arvat and M. Maccario. PREDICTORS OF RECURRENCE OF PHEOCHROMOCYTOMA AND PARAGANGLIOMA: A MULTICENTER STUDY IN PIEDMONT, ITALY. Hypertens Res. 2020 Jun;43(6):500-510.

M. Berton, N. Prencipe, R. Giordano, E. Ghigo, S. Grottoli. SYSTEMIC STEROIDS IN PATIENTS WITH COVID-19: PROS AND CONTRAS, AN ENDOCRINOLOGICAL POINT OF VIEW. J Endocrinol Invest. 2020 Jun; 8: 1–3.

Ponzetto, F. Settanni, M. Parasiliti‑Caprino, F. Rumbolo1o, A. Nonnato, M. Ricciardo, E. Amante, G. Priolo, S. Vitali, L. Anfossi, E. Arvat, E. Ghigo, R. Giordano, G. Mengozzi. Reference ranges of late-night salivary cortisol and cortisone measured by LC-MS/MS and accuracy for the diagnosis of Cushing’ syndrome. J Endocrinol Invest 2020; 43 (12): 1797-1806.

Parasiliti-Caprino, F. Bioletto, T. Frigerio, V. D'Angelo, F. Ceccato, F. Ferraù, R. Ferrigno, M. Minnetti, C. Scaroni, S. Cannavò, R. Pivonello, A. M. Isidori, F. Broglio, R. Giordano, M. Spinello, S. Grottoli and E. Arvat. A NEW CLINICAL MODEL TO ESTIMATE THE PRE-TEST PROBABILITY OF CUSHING’S SYNDROME: THE CUSHING SCORE. Front Endocrinol (Lausanne). 2021;12:747549.

Epidemiologia

Tarekegn A, Ricceri F, Costa G, Ferracin E, Giacobini M. Predictive Modeling for Frailty Conditions in Elderly People: Machine Learning Approaches. JMIR Med Inform. 2020 Jun 4;8(6):e16678

Freisling H, Viallon V, Lennon H, Bagnardi V, Ricci C, Butterworth AS, Sweeting M, Muller D, Romieu I, Bazelle P, Kvaskoff M, Arveux P, Severi G, Bamia C, Kühn T, Kaaks R, Bergmann M, Boeing H, Tjønneland A, Olsen A, Overvad K, Dahm CC, Menéndez V, Agudo A, Sánchez MJ, Amiano P, Santiuste C, Gurrea AB, Tong TYN, Schmidt JA, Tzoulaki I, Tsilidis KK, Ward H, Palli D, Agnoli C, Tumino R, Ricceri F, Panico S, Picavet HSJ, Bakker M, Monninkhof E, Nilsson P, Manjer J, Rolandsson O, Thysell E, Weiderpass E, Jenab M, Riboli E, Vineis P, Danesh J, Wareham NJ, Gunter MJ, Ferrari P. Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study. BMC Med. 2020 Jan 10;18(1):5

Sacerdote C, Ricceri F. Epidemiological dimensions of the association between type 2 diabetes and cancer: a review of observational studies. Diabetes Res Clin Pract. 2018;143:369-377

Ricceri F, Fasanelli F, Giraudo MT, Sieri S, Tumino R, Mattiello A, Vagliano L, Masala G, Quirós JR, Travier N, Sánchez MJ, Larranaga N, Chirlaque MD, Ardanaz E, Tjonneland A, Olsen A, Overvad K, Chang-Claude J, Kaaks R, Boeing H, Clavel-Chapelon F, Kvaskoff M, Dossus L, Trichopoulou A, Benetou V, Adarakis G, Bueno-de-Mesquita HB, Peeters PH, Sund M, Andersson A, Borgquist S, Butt S, Weiderpass E, Skeie G, Khaw KT, Travis RC, Rinaldi S, Romieu I, Gunter M, Kadi M, Riboli E, Vineis P, Sacerdote C. Risk of second primary malignancies in women with breast cancer: results from the European Prospective Investigation into Cancer and Nutrition (EPIC). Int J Cancer. Aug 15;137(4):940-948

Bronsino M, Castagneri C, Spinazzola M, Pepe RR, Sacerdote C, Ricceri F. "Journey of hope": a study on sexual gender-based violence reported by asylum-seeking women during their journey to Europe. Epidemiol Prev. 2020 Sep-Dec;44(5-6 Suppl 1):102-106

Ferrante G, Fasanelli F, Gigantesco A, Ferracin E, Contoli B, Costa G, Gargiulo L, Marra M, Masocco M, Minardi V, Violani C, Zengarini N, d'Errico A, Ricceri F. Is the association between precarious employment and mental health mediated by economic difficulties in males? Results from two Italian studies. BMC Public Health. 2019 Jul 3;19(1):869

Stringhini S, Carmeli C, Jokela M, Avendaño M, Muennig P, Guida F, Ricceri F, d’Errico A, Barros H, Bochud M, Chadeau-Hyam M, Clavel-Chapelon F, Costa G, Delpierre C, Fraga S, Goldberg M, Giles G, Krogh V, Kelly Irving M, Layte R, Lasserre AM, Marmot MG, Preisig M, Shipley MJ, Vollenweider P, Zins M, Kawachi I, Steptoe A, Mackenbach JP, Vineis P, Kivimäki M, the LIFEPATH consortium. Socioeconomic status and the 25 × 25 risk factors as determinants of premature mortality: a multicohort study and meta-analysis of 1 × 7 million men and women. 2017 Jan 31. pii: S0140-6736(16)32380-7

Ricceri F, Sacerdote C, Giraudo MT, Fasanelli F, Lenzo G, Galli M, Sieri S, Pala V, Masala G, Bendinelli B, Tumino R, Frasca G, Chiodini P, Mattiello A, Panico R. The association between Socioeconomic Status and Cardiovascular and Cerebrovascular Diseases within the EPICOR study: new evidence for an old inequality problem. PLoS One. Oct 6;11(10):e0164130

Sacerdote C, Ricceri F, Rolandsson O, Baldi I, Chirlaque MD, Feskens E, Bendinelli B, Ardanaz E, Arriola L, Balkau B, Bergmann M, Beulens JWJ, Boeing H, Clavel-Chapelon F, Crowe F, de Lauzon-Guillain B, Forouhi N, Franks P, Gallo V, Gonzalez C, Halkjær J, Illner AK, Kaaks R, Key T, Khaw KT, Navarro C, Nilsson PM, Oksbjerg Dal ton S, Overvad K, Pala V, Palli D, Panico S, Polidoro S, Quirós JR, Romieu I, Sánchez MJ, Slimani N, Sluijs I, Spijkerman A, Teucher B, Tjønneland A, Tumino R, van der A D, Vergnaud AC, Wennberg P, Sharp S, Langenberg C, Riboli E, Vineis P, Wareham N. Lower educational level is a predictor of incident type 2 diabetes in European Countries. The EPIC-InterAct Study. Int J Epidemiology. 2012 Aug; 41(4):1162-73

Caramello V, Macciotta A, Bar F, Mussa A, De Leo AM, De Salve AV, Nota F, Sacerdote C, Ricceri F, Boccuzzi A. The broad spectrum of COVID-like patients initially negative at RT-PCR testing: a cohort study. BMC Public Health. 2022 Jan 7;22(1):45

Caramello V, Boccuzzi A, Basile V, Ferraro A, Macciotta A, Catalano A, Costa G, Vineis P, Sacerdote C, Ricceri F. Are antigenic tests useful for detecting SARS-CoV-2 infections in patients accessing to emergency departments? Results from a North-West Italy Hospital. J Infect. 2021 May 20:S0163-4453(21)00255-3

Fornili M, Petri D, Berrocal C, Fiorentino G, Ricceri F, Macciotta A, Bruno A, Farinella D, Baccini M, Severi G, Baglietto L. Psychological distress in the academic population and its association with socio-demographic and lifestyle characteristics during COVID-19 pandemic lockdown: Results from a large multicenter Italian study. PLoS One. 2021 Mar 10;16(3):e0248370

Caramello V, Maciotta A, De Salve AV, Gobbi V, Ruffino TM, Mazzetti G, Ricagni L, Ling C, Arione R, Boccuzzi A, Costa G, Sacerdote C, Ricceri F. Clinical characteristics and management of COVID-19 patients accessing the emergency department in a hospital in Northern Italy in March and April 2020. Epidemiol Prev. 2020 Sep-Dec;44(5-6 Suppl 2):208-215

Gnavi R, Demaria M, Picariello R, Dalmasso M, Ricceri F, Costa G. Therapy with agents acting on the renin-angiotensin system and risk of SARS-CoV-2 infection. Clin Infect Dis. 2020;71(16):2291-2293

Genomic Regulation Group

• Elhasnaoui J, Ferrero G, Miano V, Cutrupi S, De Bortoli M. The Estrogen Receptor α Signaling Pathway Controls Alternative Splicing in the Absence of Ligands in Breast Cancer Cells. Cancers. 2021 Jan;13(24):6261. doi: 10.3390/cancers13246261
• Giordano G, Merlini A, Ferrero G, Mesiano G, Fiorino E, Brusco S, Centomo ML, Leuci V, D'Ambrosio L, Aglietta M, Sangiolo D, Grignani G, Pignochino Y. EphA2 Expression in Bone Sarcomas: Bioinformatic Analyses and Preclinical Characterization in Patient-Derived Models of Osteosarcoma, Ewing's Sarcoma and Chondrosarcoma. Cells. 2021 Oct 26;10(11):2893. doi: 10.3390/cells10112893.
• Ferrero G, Licheri N, Coscujuela Tarrero L, De Intinis C, Miano V, Calogero RA, Cordero F, De Bortoli M, Beccuti M. Docker4Circ: a framework for the reproducible characterization of circRNAs from RNA-Seq data. International journal of molecular sciences. 2020 Jan;21(1):293.
• Guglielmotto M, Reineri S, Iannello A, Ferrero G, Vanzan L, Miano V, Ricci L, Tamagno E, De Bortoli M, Cutrupi S.E2 Regulates Epigenetic Signature on Neuroglobin Enhancer-Promoter in Neuronal Cells. Front Cell Neurosci. 2016 Jun 1;10:147
• Caizzi L, Ferrero G, Cutrupi S, Cordero F, Ballaré C, Miano V, Reineri S, Ricci L, Friard O, Testori A, Corà D, Caselle M, Di Croce L, De Bortoli M.Genome-wide activity of unliganded estrogen receptor-α in breast cancer cells. Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4892-7.

Hepatic Pathophysiology and Hepatocellular Carcinoma

• Morello E, Sutti S, Foglia B, Novo E, Cannito S, Bocca C, Rajsky M, Bruzzì S, Abate ML, Rosso C, Bozzola C, David E, Bugianesi E, Albano E, Parola M.
  Hypoxia-inducible factor 2α drives nonalcoholic fatty liver progression by triggering hepatocyte release of histidine-rich glycoprotein.
  Hepatology. 2018 Jun; 67(6):2196-2214
  https://doi.org/10.1002/hep.29754
• Parola M, Pinzani M.
  Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues.
  Mol Aspects Med. 2019 Feb; 65:37-55.
  https://doi.org/10.1016/j.mam.2018.09.002
• Cannito S, Foglia B, Villano G, Turato C, Delgado TC, Morello E, Pin F, Novo E, Napione L, Quarta S, Ruvoletto M, Fasolato S, Zanus G, Colombatto S, Lopitz-Otsoa F, Fernández-Ramos D, Bussolino F, Sutti S, Albano E, Martínez-Chantar ML, Pontisso P, Parola M.
  SerpinB3 Differently Up-Regulates Hypoxia Inducible Factors -1α and -2α in Hepatocellular Carcinoma: Mechanisms Revealing Novel Potential Therapeutic Targets.
  Cancers (Basel). 2019 Dec 4;11(12):1933.
  https://doi.org/10.3390/cancers11121933
• Foglia B, Sutti S, Cannito S, Rosso C, Maggiora M, Autelli R, Novo E, Bocca C, Villano G, Ramavath NN, Younes R, Tusa I, Rovida E, Pontisso P, Bugianesi E, Albano E, Parola M.
  Hepatocyte-Specific Deletion of HIF2α Prevents NASH-Related Liver Carcinogenesis by Decreasing Cancer Cell Proliferation.
  Cell Mol Gastroenterol Hepatol. 2022;13(2):459-482.
  https://doi.org/10.1016/j.jcmgh.2021.10.002
• Di Maira G, Foglia B, Napione L, Turato C, Maggiora M, Sutti S, Novo E, Alvaro M, Autelli R, Colombatto S, Bussolino F, Carucci P, Gaia S, Rosso C, Biasiolo A, Pontisso P, Bugianesi E, Albano E, Marra F, Parola M, Cannito S.
  Oncostatin M is overexpressed in NASH-related hepatocellular carcinoma and promotes cancer cell invasiveness and angiogenesis.
  J Pathol. 2022 Jan 22.
  https://doi.org/10.1002/path.5871

Innovative medicine and molecular genetics

• Vitale E, Rossin D, Perveen S, Miletto I, Lo Iacono M, Rastaldo R, Giachino C. Silica Nanoparticle Internalization Improves Chemotactic Behaviour of Human Mesenchymal Stem Cells Acting on the SDF1α/CXCR4 Axis. Biomedicines 2022, 10(2), 336. doi.org/10.3390/biomedicines10020336
• Lo Iacono M, Puglisi S, Perotti P, Saba L, Petiti J, Giachino C, Reimondo G, Terzolo M. Molecular Mechanisms of Mitotane Action in Adrenocortical Cancer Based on In Vitro Studies. Cancers (Basel). 2021 Oct 20;13(21):5255. doi: 10.3390/cancers13215255.
• Lo Iacono M, Signorino E, Petiti J, Pradotto M, Calabrese C, Panuzzo C, Caciolli F, Pergolizzi B, De Gobbi M, Rege-Cambrin G, Fava C, Giachino C, Bracco E, Saglio G, Frassoni F, Cilloni D. Genetic Screening for Potential New Targets in Chronic Myeloid Leukemia Based on Drosophila Transgenic for Human BCR-ABL1. Cancers (Basel). 2021 Jan 14;13(2):293. doi: 10.3390/cancers13020293.
• Bellotti E, Cascone MG, Barbani N, Rossin D, Rastaldo R, Giachino C, Cristallini C. Targeting Cancer Cells Overexpressing Folate Receptors with New Terpolymer-Based Nanocapsules: Toward a Novel Targeted DNA Delivery System for Cancer Therapy. Biomedicines. 2021 Sep 21;9(9):1275. doi: 10.3390/biomedicines9091275.
• Cristallini C, Vaccari G, Barbani N, Cibrario Rocchietti E, Barberis R, Falzone M, Cabiale K, Perona G, Bellotti E, Rastaldo R, Pascale S, Pagliaro P, Giachino C. Cardioprotection of PLGA/gelatine cardiac patches functionalised with adenosine in a large animal model of ischaemia and reperfusion injury: A feasibility study. J Tissue Eng Regen Med. 2019 Jul;13(7):1253-1264. doi: 10.1002/term.2875.

Internal medicine

Adjuvant mitotane versus surveillance in low-grade, localised adrenocortical carcinoma (ADIUVO): an international, multicentre, open-label, randomised, phase 3 trial and observational study

Terzolo M, Fassnacht M, Perotti P, Libé R, Kastelan D, Lacroix A, Arlt W, Haak HR, Loli P, Decoudier B, Lasolle H, Quinkler M, Haissaguerre M, Chabre O, Caron P, Stigliano S, Giordano R, Zatelli MC, Bancos I, Fragoso MCBV, Canu L, Luconi M, Puglisi S, Basile V, Reimondo G, Kroiss M, Megerle F, Hahner S, Kimpel O, Dusek T, Nölting S, Bourdeau I, Chortis V, Ettaieb MH, Cosentini D, Grisanti S, Baudin E, Berchialla P, Bovis F, Sormani MP, Bruzzi P, Beuschlein F, Bertherat J, Berruti A.

Lancet Diabetes Endocrinol 2023                

doi: 10.1016/ S2213-8587(23)00193-6

 

Long-Term Consequences of Cushing's Syndrome: A Systematic Literature Review.
Puglisi S, Perini AME, Botto C, Oliva F, Terzolo M.      

J Clin Endocrinol Metab 2023; dgad453                      

doi: 10.1210/clinem/dgad453

 

European Society of Endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in collaboration with the European Network for the Study of Adrenal Tumors.

Fassnacht M, Tsagarakis S, Terzolo M, Tabarin A, Sahdev A, Newell-Price J, Pelsma I, Marina L, Lorenz K, Bancos I, Arlt W, Dekkers OM. Eur J Endocrinol. 2023; 189:G1-G42.

doi: 10.1093/ejendo/lvad066

 

New findings on presentation and outcome of patients with adrenocortical cancer: results from a national cohort study.

Puglisi S, Calabrese A, Ferraù F, Violi MA, Laganà M, Grisanti S, Ceccato F, Scaroni C, Dalmazi GD, Stigliano A, Altieri B, Canu L, Loli P, Pivonello R, Arvat E, Morelli V, Perotti P, Basile V, Berchialla P, Urru S, Fiori C, Porpiglia F, Berruti A, Pia A, Reimondo G, Cannavò S, Terzolo M.

J Clin Endocrinol Metab 2023: dgad199.      

doi: 10.1210/clinem/dgad199

 

The management of postoperative disease recurrence in patients with adrenocortical carcinoma: a retrospective study in 106 patients.

Calabrese A, Puglisi S, Borin C, Basile V, Perotti P, Pia A, Berchialla P, Volante M, Fiori C, Porpiglia F, Veltri A, Reimondo G, Terzolo M.

Eur J Endocrinol. 2023; 188:lvad002.       

doi: 10.1093/ejendo/lvad002

 

Age-dependent and sex-dependent disparity in mortality in patients with adrenal incidentalomas and autonomous cortisol secretion: an international, retrospective, cohort study.

Deutschbein T, Reimondo G, Di Dalmazi G, Bancos I, Patrova J, Vassiliadi DA, Nekić AB, Debono M, Lardo P, Ceccato F, Petramala L, Prete A, Chiodini I, Ivović M, Pazaitou-Panayiotou K, Alexandraki KI, Hanzu FA, Loli P, Yener S, Langton K, Spyroglou A, Kocjan T, Zacharieva S, Valdés N, Ambroziak U, Suzuki M, Detomas M, Puglisi S, Tucci L, Delivanis DA, Margaritopoulos D, Dusek T, Maggio R, Scaroni C, Concistrè A, Ronchi CL, Altieri B, Mosconi C, Diamantopoulos A, Iñiguez-Ariza NM, Vicennati V, Pia A, Kroiss M, Kaltsas G, Chrisoulidou A, Marina LV, Morelli V, Arlt W, Letizia C, Boscaro M, Stigliano A, Kastelan D, Tsagarakis S, Athimulam S, Pagotto U, Maeder U, Falhammar H, Newell-Price J, Terzolo M, Fassnacht M.

Lancet Diabetes Endocrinol 2022; 10:499-508.

doi: 10.1016/S2213-8587(22)00100-0

 

Limited Role of Hair Cortisol and Cortisone Measurement for Detecting Cortisol Autonomy in Patients With Adrenal Incidentalomas.

Puglisi S, Leporati M, Amante E, Parisi A, Pia AR, Berchialla P, Terzolo M, Vincenti M, Reimondo G.  

Front Endocrinol 2022; 13:833514.              

doi: 10.3389/fendo.2022.833514

 

A Multicenter Epidemiological Study on Second Malignancy in Non-Syndromic Pheochromocytoma / Paraganglioma Patients in Italy.

Canu L, Puglisi S, Berchialla P, De Filpo G, Brignardello F, Schiavi F, Ferrara AM, Zovato S, Luconi M, Pia A, Appetecchia M, Arvat E, Letizia C, Maccario M, Parasiliti-Caprino M, Altieri B, Faggiano A, Modica R, Morelli V, Arosio M, Verga U, Pellegrino M, Petramala L, Concistrè A, Razzore P, Ercolino T, Rapizzi E, Maggi M, Stigliano A, Burrello J, Terzolo M, Opocher G, Mannelli M, Reimondo G.

Cancers 2021; 13:5831                                 

doi: 10.3390/cancers13225831   

 

What Is the Optimal Duration of Adjuvant Mitotane Therapy in Adrenocortical Carcinoma? An Unanswered Question.

Basile V, Puglisi S, Altieri B, Canu L, Libè R, Ceccato F, Beuschlein F, Quinkler M, Calabrese A, Perotti P, Berchialla P, Dischinger U, Megerle F, Baudin E, Bourdeau I, Lacroix A, Loli P, Berruti A, Kastelan D, Haak HR, Fassnacht M, Terzolo M.

J Pers Med 2021; 11:269                          

doi: 10.3390/jpm11040269    

 

ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org. Adrenocortical carcinomas and malignant phaeochromocytomas: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up.

Fassnacht M, Assie G, Baudin E, Eisenhofer G, de la Fouchardiere C, Haak HR, de Krijger R, Porpiglia F, Terzolo M, Berruti A;

Ann Oncol. 2020; 31:1476-1490.

doi: 10.1016/j.annonc.2020.08.2099

 

Mitotane Concentrations Influence Outcome in Patients with Advanced Adrenocortical Carcinoma

Puglisi S, Calabrese A, Basile V, Ceccato F, Scaroni C, Altieri B, Della Casa S, Loli P, Pivonello R, De Martino MC, Canu L, Russo M, Badalamenti G, Torlontano M, Stigliano A, Ferraù F, Arnaldi G, Saba L, Quirino A, Perotti P, Berchialla P, Terzolo M., Cancers 2020; 12:740

doi: 10.3390/cancers12030740

 

Unwanted Hormonal and Metabolic Effects of Postoperative Adjuvant Mitotane Treatment for Adrenocortical Cancer

Basile V, Puglisi S, Calabrese A, Pia A, Perotti P, Berruti A, Reimondo G, Terzolo M.

Cancers 2020; 12:2615

doi: 10.3390/cancers12092615

 

Adrenal incidentalomas are tied to increased risk of diabetes: findings from a prospective study

Reimondo G, Castellano E, Grosso M, Puglisi S, Pia A, Pellegrino M, Borretta G, Terzolo M.

J Clin Endocrinol Metab 2020; 105: dgz284

doi: 10.1210/clinem/dgz284

 

Adjuvant mitotane therapy is beneficial in non-metastatic adrenocortical carcinoma at high risk of recurrence

Calabrese A, Basile V, Puglisi S, Perotti P, Pia A, Saba L, Berchialla P, Porpiglia F, Veltri A, Volante M, Reimondo G, Berruti A, Terzolo M.

Eur J Endocrinol 2019; 180:387-396

doi: 10.1530/EJE-18-0923

 

Mitotane Concentrations Influence the Risk of Recurrence in Adrenocortical Carcinoma Patients on Adjuvant Treatment.

Puglisi S, Calabrese A, Basile V, Ceccato F, Scaroni C, Simeoli C, Torlontano M, Cannavò S, Arnaldi G, Stigliano A, Malandrino P, Saba L, Altieri B, Della Casa S, Perotti P, Berchialla P, De Filpo G, Canu L, Loli P, Reimondo G, Terzolo M.

J Clin Med 2019; 8:1850 

doi: 10.3390/jcm8111850

 

European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors.

Fassnacht M, Dekkers OM, Else T, Baudin E, Berruti A, de Krijger R, Haak HR, Mihai R, Assie G, Terzolo M.

Eur J Endocrinol. 2018; 179:G1-G46.

doi: 10.1530/EJE-18-0608

 

Determination of salivary cortisol to assess time-related changes of the adrenal response to stress in critically ill patients.

Puglisi S, Pizzuto A, Laface B, Panero F, Aprà F, Palmas E, Perotti P, Reimondo G, Boccuzzi A, Terzolo M.

Eur J Intern Med 2019; 68:66-70.

doi: 10.1016/j.ejim.2019.08.001   

 

Effects of mitotane on the hypothalamic-pituitary-adrenal axis in patients with adrenocortical carcinoma.

Reimondo G, Puglisi S, Zaggia B, Basile V, Saba L, Perotti P, De Francia S, Volante M, Zatelli MC, Cannavò S, Terzolo M.

Eur J Endocrinol. 2017; 177:361-367

doi: 10.1530/EJE-17-0452

 

Management of adrenal incidentalomas: European Society of Endocrinology Clinical Practice Guideline in collaboration with the European Network for the Study of Adrenal Tumors.

Fassnacht M, Arlt W, Bancos I, Dralle H, Newell-Price J, Sahdev A, Tabarin A, Terzolo M, Tsagarakis S, Dekkers OM.

Eur J Endocrinol. 2016; 175:G1-G34.

doi: 10.1530/EJE-16-0467

 

Surgical remission of Cushing's syndrome reduces cardiovascular risk.

Terzolo M, Allasino B, Pia A, Peraga G, Daffara F, Laino F, Ardito A, Termine A, Paccotti P, Berchialla P, Migliaretti G, Reimondo G.

Eur J Endocrinol. 2014 Jul;171(1):127-36.

doi: 10.1530/EJE-13-0555

 

Combination chemotherapy in advanced adrenocortical carcinoma.

Fassnacht M, Terzolo M, Allolio B, Baudin E, Haak H, Berruti A, Welin S, Schade-Brittinger C, Lacroix A, Jarzab B, Sorbye H, Torpy DJ, Stepan V, Schteingart DE, Arlt W, Kroiss M, Leboulleux S, Sperone P, Sundin A, Hermsen I, Hahner S, Willenberg HS, Tabarin A, Quinkler M, de la Fouchardière C, Schlumberger M, Mantero F, Weismann D, Beuschlein F, Gelderblom H, Wilmink H, Sender M, Edgerly M, Kenn W, Fojo T, Müller HH, Skogseid B; FIRM-ACT Study Group.

N Engl J Med. 2012; 366:2189-97

doi: 10.1056/NEJMoa1200966

 

Adjuvant mitotane treatment for adrenocortical carcinoma

Terzolo M, Angeli A, Fassnacht M, Daffara F, Tauchmanova L, Conton PA, Rossetto R, Buci L, Sperone P, Grossrubatscher E, Reimondo G, Bollito E, Papotti M, Saeger W, Hahner S,  Koschker AC, Arvat E, Ambrosi B, Loli P, Lombardi G, Mannelli M, Bruzzi P, Mantero F, Allolio  B, Dogliotti L, Berruti A.

N Engl J Med 2007; 356:2372-80

doi: 10.1056/NEJMoa063360

Iron Metabolism

Iron Overload, Oxidative Stress, and Ferroptosis in the Failing Heart and Liver.
Mancardi D, Mezzanotte M, Arrigo E, Barinotti A, Roetto A.
Antioxidants (Basel). 2021 Nov 24;10(12):1864. doi: 10.3390/antiox10121864.

The Functional Versatility of Transferrin Receptor 2 and Its Therapeutic Value.
Roetto A, Mezzanotte M, Pellegrino RM.
Pharmaceuticals (Basel). 2018 Oct 23;11(4):115. doi: 10.3390/ph11040115.

TFR2-Related Hereditary Hemochromatosis.
De Gobbi M, Roetto A.
2005 Aug 29 [updated 2018 Feb 15]. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Mirzaa GM, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2022.
PMID: 20301523

Transferrin Receptor 2 Dependent Alterations of Brain Iron Metabolism Affect Anxiety Circuits in the Mouse.
Pellegrino RM, Boda E, Montarolo F, Boero M, Mezzanotte M, Saglio G, Buffo A, Roetto A.
Sci Rep. 2016 Aug 1;6:30725. doi: 10.1038/srep30725.

Comparison of 3 Tfr2-deficient murine models suggests distinct functions for Tfr2-alpha and Tfr2-beta isoforms in different tissues.
Roetto A, Di Cunto F, Pellegrino RM, Hirsch E, Azzolino O, Bondi A, Defilippi I, Carturan S, Miniscalco B, Riondato F, Cilloni D, Silengo L, Altruda F, Camaschella C, Saglio G.
Blood. 2010 Apr 22;115(16):3382-9. doi: 10.1182/blood-2009-09-240960. Epub 2010 Feb 23.
PMID: 20179178

Mechanisms of autophagy-mediated anticancer drug resistance of breast and liver cancer cells

Autelli, R.; Costelli, P.; Crepaldi, T.; Penna, F.; Tamagno, E. (2016)
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
https://iris.unito.it/handle/2318/1550759

Ullio, Chiara, Brunk, Ulf T , Urani, Chiara, Melchioretto, Pasquale, Bonelli, Gabriella, Baccino, Francesco M , Autelli, Riccardo (2015)
AUTOPHAGY OF METALLOTHIONEINS PREVENTS TNF-INDUCED OXIDATIVE STRESS AND TOXICITY IN HEPATOMA CELLS.
https://iris.unito.it/handle/2318/1550662

Cannito S, Turato C, Paternostro C, Biasiolo A, Colombatto S, Cambieri I, Quarta S, Novo E, Morello E, Villano G, Cillo U, Fasolato S, Musso T, David E, Tusa I, Rovida E, Autelli R, Smedile A, Cillo U, Pontisso P, Parola M (2015)
Hypoxia up-regulates SERPINB3 through HIF-2? in human liver cancer cells.
https://iris.unito.it/handle/2318/154507

C BOCCA, M IEVOLELLA, R AUTELLI, M MOTTA, L MOSSO, B TORCHIO, F BOZZO, S CANNITO, C PATERNOSTRO, S COLOMBATTO, M PAROLA, A MIGLIETTA (2014)
EXPRESSION OF COX-2 IN HUMAN BREAST CANCER CELLS AS A CRITICAL DETERMINANT OF EPITHELIAL-MESENCHYMAL TRANSITION AND INVASIVENESS.
https://iris.unito.it/handle/2318/139953

C Ullio, J Casas, U T Brunk, G Sala, G Fabriàs, R Ghidoni, G Bonelli, F M Baccino, R Autelli (2013)
LYSOSOMAL MECHANISMS OF DEATH BY TNF IN HEPATOMA CELLS.
https://iris.unito.it/handle/2318/152996

Autelli R, Ullio C, Prigione E, Crepaldi S, Schiavone N, Brunk UT, Capaccioli S, Baccino FM, Bonelli G (2009)
Divergent pathways for TNF and C(2)-ceramide toxicity in HTC hepatoma cells.
https://iris.unito.it/handle/2318/57488

Neuroimmunology

PUBLICATIONS/PUBBLICAZIONI

Neuromuscular function

• Lupo C., Ungureanu A.N., Boccia G., Licciardi A., Rainoldi A., Brustio P.R. (2021). Internal training load monitoring, notational and time motion analyses, psychometric status, and neuromuscular responses in elite rugby union. International Journal of Sports Physiology and Performance. 16, 421–428. https://doi.org/10.1123/ijspp.2020-0260. ISSN: 1555-0265.
• Boccia G, Dardanello D, Brustio PR, Tarperi C, Festa L, Zoppirolli C, Pellegrini B, Schena F, Rainoldi A (2018) Neuromuscular fatigue does not impair the rate of force development in ballistic contractions of submaximal amplitudes, Front. Physiol. 9: 1503. doi: 10.3389/fphys.2018.01503
• Brustio, P.R., Moise, P., Marasso, D., Miglio, F., Rainoldi, A., & Boccia, G. (2018) Feasibility of implementing an outdoor walking break in Italian middle schools. PLoS ONE 13(8): e0202091. doi: 10.1371/journal.pone.0202091.
• Mulasso, A., Brustio, P.R., Rainoldi, A., Zia G., Feletti, L., N’dja, A., Del Signore, S, Poggiogalle E., Luisi F., Donini, L.M. (2019) A comparison between an ICT tool and a traditional physical measure for frailty evaluation in older adults. BMC Geriatrics, 19:88 doi: 10.1186/s12877-019-1089-z
• Brustio, P.R., Lupo, C., Ungureano A.N., Frati, R., Rainoldi, A., & Boccia, G. (2018) The relative age effect is larger in Italian soccer top-level youth categories and smaller in Serie A. PLOS ONE, 13(4): e0196253. doi:10.1371/journal.pone.0196253.

Nutrition, reactive metabolites and bioactive compounds in metabolic inflammation

Collino M, Benetti E, Rogazzo M, Mastrocola R, Yaqoob MM, Aragno M, Theimermann C, Fantozzi R. (2024) Corrigendum to "Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR-delta agonism correlates with impaired NLRP3 inflammasome activation'' [Biochem. Pharmacol. 85(2) (2013) 257-264]. Biochemical pharmacology 222 116060 [DOI  PMID]

Aimaretti E, Porchietto E, Mantegazza G, Gargari G, Collotta D, Einaudi G, Ferreira Alves G, Marzani E, Algeri A, Dal Bello F, Aragno M, Cifani C, Guglielmetti S, Mastrocola R, Collino M. (2024) Anti-Glycation Properties of Zinc-Enriched Arthrospira platensis (Spirulina) Contribute to Prevention of Metaflammation in a Diet-Induced Obese Mouse Model. Nutrients 16(4) [DOI  PMID]

Fornelli C, Sofia Cento A, Nevi L, Mastrocola R, Ferreira Alves G, Caretti G, Collino M, Penna F. (2024) The BET inhibitor JQ1 targets fat metabolism and counteracts obesity. Journal of advanced research [DOI  PMID]

Almasri F, Collotta D, Aimaretti E, Sus N, Aragno M, Dal Bello F, Eva C, Mastrocola R, Landberg R, Frank J, Collino M. (2024) Dietary Intake of Fructooligosaccharides Protects against Metabolic Derangements Evoked by Chronic Exposure to Fructose or Galactose in Rats. Molecular nutrition & food research 68(4) e2300476 [DOI  PMID]

Kar S, Perrelli A, Bali KK, Mastrocola R, Kar A, Khan B, Gand L, Nayak A, Hartmann C, Kunz WS, Samii A, Bertalanffy H, Retta SF. (2024) Identification of galectin-3 as a novel potential prognostic/predictive biomarker and therapeutic target for cerebral cavernous malformation disease. Genes & diseases 11(1) 67-71 [DOI  PMID]

Mastrocola R, Aimaretti E, Ferreira Alves G, Cento AS, Fornelli C, Dal Bello F, Ferraris C, Goitre L, Perrelli A, Retta SF. (2022) Heterozygous Loss of KRIT1 in Mice Affects Metabolic Functions of the Liver, Promoting Hepatic Oxidative and Glycative Stress. International journal of molecular sciences 23(19) [DOI  PMID]

Wouters K, Cento AS, Gaens KH, Teunissen M, Scheijen JLJM, Barutta F, Chiazza F, Collotta D, Aragno M, Gruden G, Collino M, Schalkwijk CG, Mastrocola R. (2021) Deletion of RAGE fails to prevent hepatosteatosis in obese mice due to impairment of other AGEs receptors and detoxifying systems. Scientific reports 11(1) 17373 [DOI  PMID]

Mastrocola R, Dal Bello F, Cento AS, Gaens K, Collotta D, Aragno M, Medana C, Collino M, Wouters K, Schalkwijk CG. (2021) Altered hepatic sphingolipid metabolism in insulin resistant mice: Role of advanced glycation endproducts. Free radical biology & medicine 169 425-435 [DOI  PMID]

Mastrocola R, Collotta D, Gaudioso G, Le Berre M, Cento AS, Ferreira Alves G, Chiazza F, Verta R, Bertocchi I, Manig F, Hellwig M, Fava F, Cifani C, Aragno M, Henle T, Joshi L, Tuohy K, Collino M. (2020) Effects of Exogenous Dietary Advanced Glycation End Products on the Cross-Talk Mechanisms Linking Microbiota to Metabolic Inflammation. Nutrients 12(9) [DOI  PMID]

Collotta D, Hull W, Mastrocola R, Chiazza F, Cento AS, Murphy C, Verta R, Alves GF, Gaudioso G, Fava F, Yaqoob M, Aragno M, Tuohy K, Thiemermann C, Collino M. (2020) Baricitinib counteracts metaflammation, thus protecting against diet-induced metabolic abnormalities in mice. Molecular metabolism 39 101009 [DOI  PMID]

Felicetti F, Cento AS, Fornengo P, Cassader M, Mastrocola R, D'Ascenzo F, Settanni F, Benso A, Arvat E, Collino M, Fagioli F, Aragno M, Brignardello E. (2020) Advanced glycation end products and chronic inflammation in adult survivors of childhood leukemia treated with hematopoietic stem cell transplantation. Pediatric blood & cancer 67(3) e28106 [DOI  PMID]

Vieceli Dalla Sega F, Mastrocola R, Aquila G, Fortini F, Fornelli C, Zotta A, Cento AS, Perrelli A, Boda E, Pannuti A, Marchi S, Pinton P, Ferrari R, Rizzo P, Retta SF. (2019) KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction. International journal of molecular sciences 20(19) [DOI  PMID]

Purvis GSD, Collino M, Loiola RA, Baragetti A, Chiazza F, Brovelli M, Sheikh MH, Collotta D, Cento A, Mastrocola R, Aragno M, Cutrin JC, Reutelingsperger C, Grigore L, Catapano AL, Yaqoob MM, Norata GD, Solito E, Thiemermann C. (2019) Identification of AnnexinA1 as an Endogenous Regulator of RhoA, and Its Role in the Pathophysiology and Experimental Therapy of Type-2 Diabetes. Frontiers in immunology 10 571 [DOI  PMID]

Barutta F, Bellini S, Mastrocola R, Gambino R, Piscitelli F, di Marzo V, Corbetta B, Vemuri VK, Makriyannis A, Annaratone L, Bruno G, Gruden G. (2018) Reversal of albuminuria by combined AM6545 and perindopril therapy in experimental diabetic nephropathy. British journal of pharmacology 175(23) 4371-4385 [DOI  PMID]

Barutta F, Bellini S, Mastrocola R, Bruno G, Gruden G. (2018) MicroRNA and Microvascular Complications of Diabetes. International journal of endocrinology 2018 6890501 [DOI  PMID]

Barutta F, Bruno G, Mastrocola R, Bellini S, Gruden G. (2018) The role of cannabinoid signaling in acute and chronic kidney diseases. Kidney international 94(2) 252-258 [DOI  PMID]

Mastrocola R, Ferrocino I, Liberto E, Chiazza F, Cento AS, Collotta D, Querio G, Nigro D, Bitonto V, Cutrin JC, Rantsiou K, Durante M, Masini E, Aragno M, Cordero C, Cocolin L, Collino M. (2018) Fructose liquid and solid formulations differently affect gut integrity, microbiota composition and related liver toxicity: a comparative in vivo study. The Journal of nutritional biochemistry 55 185-199 [DOI  PMID]

Bressanello D, Liberto E, Collino M, Chiazza F, Mastrocola R, Reichenbach SE, Bicchi C, Cordero C. (2018) Combined untargeted and targeted fingerprinting by comprehensive two-dimensional gas chromatography: revealing fructose-induced changes in mice urinary metabolic signatures. Analytical and bioanalytical chemistry 410(11) 2723-2737 [DOI  PMID]

Barutta F, Mastrocola R, Bellini S, Bruno G, Gruden G. (2018) Cannabinoid Receptors in Diabetic Kidney Disease. Current diabetes reports 18(2) 9 [DOI  PMID]

Benetti E, Mastrocola R, Chiazza F, Nigro D, D'Antona G, Bordano V, Fantozzi R, Aragno M, Collino M, Minetto MA. (2018) Effects of vitamin D on insulin resistance and myosteatosis in diet-induced obese mice. PloS one 13(1) e0189707 [DOI  PMID]

Bellini S, Barutta F, Mastrocola R, Imperatore L, Bruno G, Gruden G. (2017) Heat Shock Proteins in Vascular Diabetic Complications: Review and Future Perspective. International journal of molecular sciences 18(12) [DOI  PMID]

Chiazza F, Cento AS, Collotta D, Nigro D, Rosa G, Baratta F, Bitonto V, Cutrin JC, Aragno M, Mastrocola R, Collino M. (2017) Protective Effects of Pyridoxamine Supplementation in the Early Stages of Diet-Induced Kidney Dysfunction. BioMed research international 2017 2682861 [DOI  PMID]

Spallotta F, Cencioni C, Atlante S, Garella D, Cocco M, Mori M, Mastrocola R, Kuenne C, Guenther S, Nanni S, Azzimato V, Zukunft S, Kornberger A, Surun D, Schnutgen F, von Melchner H, Di Stilo A, Aragno M, Braspenning M, van Criekinge W, De Blasio MJ, Ritchie RH, Zaccagnini G, Martelli F, Farsetti A, Fleming I, Braun T, Beiras-Fernandez A, Botta B, Collino M, Bertinaria M, Zeiher AM, Gaetano C. (2018) Stable Oxidative Cytosine Modifications Accumulate in Cardiac Mesenchymal Cells From Type2 Diabetes Patients: Rescue by alpha-Ketoglutarate and TET-TDG Functional Reactivation. Circulation research 122(1) 31-46 [DOI  PMID]

Aragno M, Mastrocola R. (2017) Dietary Sugars and Endogenous Formation of Advanced Glycation Endproducts: Emerging Mechanisms of Disease. Nutrients 9(4) [DOI  PMID]

Mastrocola R, Aragno M, Alloatti G, Collino M, Penna C, Pagliaro P. (2018) Metaflammation: Tissue-Specific Alterations of the NLRP3 Inflammasome Platform in Metabolic Syndrome. Current medicinal chemistry 25(11) 1294-1310 [DOI  PMID]

Nigro D, Menotti F, Cento AS, Serpe L, Chiazza F, Dal Bello F, Romaniello F, Medana C, Collino M, Aragno M, Mastrocola R. (2017) Chronic administration of saturated fats and fructose differently affect SREBP activity resulting in different modulation of Nrf2 and Nlrp3 inflammasome pathways in mice liver. The Journal of nutritional biochemistry 42 160-171 [DOI  PMID]

Mastrocola R. (2017) AGEs and neurodegeneration: the Nrf2/glyoxalase-1 interaction. Oncotarget 8(4) 5645-5646 [DOI  PMID]

Mastrocola R, Penna C, Tullio F, Femmino S, Nigro D, Chiazza F, Serpe L, Collotta D, Alloatti G, Cocco M, Bertinaria M, Pagliaro P, Aragno M, Collino M. (2016) Pharmacological Inhibition of NLRP3 Inflammasome Attenuates Myocardial Ischemia/Reperfusion Injury by Activation of RISK and Mitochondrial Pathways. Oxidative medicine and cellular longevity 2016 5271251 [DOI  PMID]

Benetti E, Mastrocola R, Vitarelli G, Cutrin JC, Nigro D, Chiazza F, Mayoux E, Collino M, Fantozzi R. (2016) Empagliflozin Protects against Diet-Induced NLRP-3 Inflammasome Activation and Lipid Accumulation. The Journal of pharmacology and experimental therapeutics 359(1) 45-53 [DOI  PMID]

Mastrocola R, Nigro D, Cento AS, Chiazza F, Collino M, Aragno M. (2016) High-fructose intake as risk factor for neurodegeneration: Key role for carboxy methyllysine accumulation in mice hippocampal neurons. Neurobiology of disease 89 65-75 [DOI  PMID]

Mastrocola R, Collino M, Penna C, Nigro D, Chiazza F, Fracasso V, Tullio F, Alloatti G, Pagliaro P, Aragno M. (2016) Maladaptive Modulations of NLRP3 Inflammasome and Cardioprotective Pathways Are Involved in Diet-Induced Exacerbation of Myocardial Ischemia/Reperfusion Injury in Mice. Oxidative medicine and cellular longevity 2016 3480637 [DOI  PMID]

Mastrocola R, Nigro D, Chiazza F, Medana C, Dal Bello F, Boccuzzi G, Collino M, Aragno M. (2016) Fructose-derived advanced glycation end-products drive lipogenesis and skeletal muscle reprogramming via SREBP-1c dysregulation in mice. Free radical biology & medicine 91 224-35 [DOI  PMID]

Chiazza F, Couturier-Maillard A, Benetti E, Mastrocola R, Nigro D, Cutrin JC, Serpe L, Aragno M, Fantozzi R, Ryffel B, Thiemermann C, Collino M. (2016) Targeting the NLRP3 Inflammasome to Reduce Diet-Induced Metabolic Abnormalities in Mice. Molecular medicine (Cambridge, Mass.) 21(1) 1025-1037 [DOI  PMID]

De Stefanis D, Mastrocola R, Nigro D, Costelli P, Aragno M. (2017) Effects of chronic sugar consumption on lipid accumulation and autophagy in the skeletal muscle. European journal of nutrition 56(1) 363-373 [DOI  PMID]

Mastrocola R, Collino M, Nigro D, Chiazza F, D'Antona G, Aragno M, Minetto MA. (2015) Accumulation of advanced glycation end-products and activation of the SCAP/SREBP Lipogenetic pathway occur in diet-induced obese mouse skeletal muscle. PloS one 10(3) e0119587 [DOI  PMID]

Sansoe G, Mastrocola R, Aragno M, Parola M. (2014) Dynamics of sodium retention in preascitic cirrhotic rats assessed through parathyroid hormone injection. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 65(5) 649-57 [PMID]

Collino M, Mastrocola R, Nigro D, Chiazza F, Aragno M, D'Antona G, Minetto MA. (2014) Variability in myosteatosis and insulin resistance induced by high-fat diet in mouse skeletal muscles. BioMed research international 2014 569623 [DOI  PMID]

Collino M, Benetti E, Rogazzo M, Chiazza F, Mastrocola R, Nigro D, Cutrin JC, Aragno M, Fantozzi R, Minetto MA, Thiemermann C. (2014) A non-erythropoietic peptide derivative of erythropoietin decreases susceptibility to diet-induced insulin resistance in mice. British journal of pharmacology 171(24) 5802-15 [DOI  PMID]

Obstructive Pulmonary Disease Group

 

• Ricciardolo, F.L.M.; Guida, Giuseppe; Bertolini, Francesca; Di Stefano, Antonino; Carriero, Vitina Phenotype overlap in the natural history of asthma. Eur Respir Rev. 2023;32:220201.
• Kim RY, Sunkara KP, Bracke KR, Jarnicki AG, Donovan C, Hsu AC, Ieni A, Beckett EL, Galvão I, Wijnant S, Ricciardolo FL, Di Stefano A, Haw TJ, Liu G, Ferguson AL, Palendira U, Wark PA, Conickx G, Mestdagh P, Brusselle GG, Caramori G, Foster PS, Horvat JC, Hansbro PM. A microRNA-21-mediated SATB1/S100A9/NF-κB axis promotes chronic obstructive pulmonary disease pathogenesis. Sci Transl Med. 2021 Nov 24;13(621):eaav7223. doi: 10.1126/scitranslmed.aav7223.
• Ricciardolo FLM, Sprio AE, Baroso A, Gallo F, Riccardi E, Bertolini F, Carriero V, Arrigo E, Ciprandi G. Characterization of T2-Low and T2-High Asthma Phenotypes in Real-Life. Biomedicines. 2021 Nov 13;9(11):1684. doi: 10.3390/biomedicines9111684.
• Bertolini F, Carriero V, Bullone M, Sprio AE, Defilippi I, Sorbello V, Gani F, Di Stefano A, Ricciardolo FLM. Correlation of matrix-related airway remodeling and bradykinin B1 receptor expression with fixed airflow obstruction in severe asthma. Allergy. 2021 Jun;76(6):1886-1890. doi: 10.1111/all.14691
• Carriero V, Bertolini F, Sprio AE, Bullone M, Ciprandi G, Ricciardolo FLM. High levels of plasma fibrinogen could predict frequent asthma exacerbations. J Allergy Clin Immunol Pract. Jul-Aug 2020;8(7):2392-2395.e7. doi: 10.1016/j.jaip.2020.02.034.
• Bullone M, Carriero V, Bertolini F, Folino A, Mannelli A, Di Stefano A, Gnemmi I, Torchio R, Ricciardolo FLM. Elevated serum IgE, oral corticosteroid dependence and IL-17/22 expression in highly neutrophilic asthma. Eur Respir J. 2019 Nov 7;54(5):1900068. doi: 10.1183/13993003.00068-2019.

Pathophysiology of inflammatory intestinal diseases

Rossin D, Barbosa-Pereira L, Iaia N, Sottero B, Danzero AC, Poli G, Zeppa G, Biasi F. Protective Effect of Cocoa Bean Shell against Intestinal Damage: An Example of Byproduct Valorization. Antioxidants (Basel). 2021 Feb 12;10(2):280. doi: 10.3390/antiox10020280. PMID: 33673085; PMCID: PMC7918452.

Rossin D, Barbosa-Pereira L, Iaia N, Testa G, Sottero B, Poli G, Zeppa G, Biasi F. A Dietary Mixture of Oxysterols Induces In Vitro Intestinal Inflammation through TLR2/4 Activation: The Protective Effect of Cocoa Bean Shells. Antioxidants (Basel). 2019 May 31;8(6):151. doi: 10.3390/antiox8060151. PMID: 31151323; PMCID: PMC6617147.

Rossin D, Dias IHK, Solej M, Milic I, Pitt AR, Iaia N, Scoppapietra L, Devitt A, Nano M, Degiuli M, Volante M, Caccia C, Leoni V, Griffiths HR, Spickett CM, Poli G, Biasi F. Increased production of 27-hydroxycholesterol in human colorectal cancer advanced stage: Possible contribution to cancer cell survival and infiltration. Free Radic Biol Med. 2019 May 20;136:35-44. doi: 10.1016/j.freeradbiomed.2019.03.020. Epub 2019 Mar 23. PMID: 30910555.

Serra G, Incani A, Serreli G, Porru L, Melis MP, Tuberoso CIG, Rossin D, Biasi F, Deiana M. Olive oil polyphenols reduce oxysterols -induced redox imbalance and pro-inflammatory response in intestinal cells. Redox Biol. 2018 Jul;17:348-354. doi: 10.1016/j.redox.2018.05.006. Epub 2018 May 16. PMID: 29793168; PMCID: PMC6007813.

Sottero B, Rossin D, Poli G, Biasi F. Lipid Oxidation Products in the Pathogenesis of Inflammation-related Gut Diseases. Curr Med Chem. 2018;25(11):1311-1326. doi: 10.2174/0929867324666170619104105. PMID: 28625152

Peripheral nerve regeneration group

El Soury M, Fornasari BE, Carta G, Zen F, Haastert-Talini K, Ronchi G. The Role of Dietary Nutrients in Peripheral Nerve Regeneration. Int J Mol Sci. 2021, 10; 22:7417.

Fornasari BE, Carta G, Gambarotta G, Raimondo S. Natural-Based Biomaterials for Peripheral Nerve Injury Repair. Front Bioeng Biotechnol. 2020, 16; 8:554257.

Fregnan F, Muratori L, Bassani GA, Crosio A, Biagiotti M, Vincoli V, Carta G, Pierimarchi P, Geuna S, Alessandrino A, Freddi G, Ronchi G. Preclinical Validation of SilkBridge^TM for Peripheral Nerve Regeneration. Front Bioeng Biotechnol. 2020, 7; 8:835.

Fornasari BE, El Soury M, Nato G, Fucini A, Carta G, Ronchi G, Crosio A, Perroteau I, Geuna S, Raimondo S, Gambarotta G. Fibroblasts Colonizing Nerve Conduits Express High Levels of Soluble Neuregulin1, a Factor Promoting Schwann Cell Dedifferentiation. Cells. 2020, 1; 9:1366.

Muratori L, Fregnan F, Ronchi G, Haastert-Talini K, Metzen J, Bertolo R, Porpiglia F, Geuna S. New basic insights on the potential of a chitosan-based medical device for improving functional recovery after radical prostatectomy. BJU Int. 2019, 124:1063-1076.

Polyunsaturated fatty acids in oncology and Tissue regeneration

PUBBLICAZIONI/PUBLICATIONS

• Schierano G, Baldi D, Peirone B, Mauthe von Degerfeld M, Navone R, Bragoni A, Colombo J, Autelli R, Muzio G. Biomolecular, Histological, Clinical, and Radiological Analyses of Dental Implant Bone Sites Prepared Using Magnetic Mallet Technology: A Pilot Study in Animals. Materials (Basel). 2021 Nov 17;14(22):6945. doi: 10.3390/ma14226945.
• Schierano G, Canuto RA, Mauthe von Degerfeld M, Navone R, Peirone B, Preti G, Muzio G. Role of rhBMP-7, Fibronectin, And Type I Collagen in Dental Implant Osseointegration Process: An Initial Pilot Study on Minipig Animals. Materials (Basel). 2021 Apr 24;14(9):2185. doi: 10.3390/ma14092185.

Psychiatry

Francesco Oliva, Giulia di Girolamo, Francesca Malandrone, Noemi Iaia, Fiorella Biasi & Giuseppe Maina. Early childhood infections, antistreptococcal and basal ganglia antibodies in adult ADHD: a preliminary study. BMC Psychiatry 20, 542 (2020). https://doi.org/10.1186/s12888-020-02946-w

Sanità pubblica

PUBBLICAZIONI/PUBLICATIONS

• Piccoli Giorgina Barbara, Chatrenet Antoine, Cataldo Manuela, Torreggiani Massimo, Attini Rossella, Masturzo Bianca, Cabiddu Gianfranca, Versino Elisabetta. Adding creatinine to routine pregnancy tests: a decision tree for calculating the cost of identifying patients with CKD in pregnancy (Accepted) Neph Dyal Trans
• Blanchi S, Torreggiani M, Chatrenet A, Fois A, Mazé B, Njandjo L, Bianco G, Lepori N, Pili A, Michel PA, Sileno G, Arazzi M, Esposito V, Pani A, Versino E, Esposito C, Fessi H, Cabiddu G, Piccoli GB. COVID-19 Vaccine Hesitancy in Patients on Dialysis in Italy and France. Kidney Int Rep. 2021 Nov;6(11):2763-2774. doi: 10.1016/j.ekir.2021.08.030. Epub 2021 Sep 8.
• Covella B; Vinturache AE Cabiddu G; Attini R; Gesualdo L; Versino E; Piccoli GB. A systematic review and meta-analysis indicates long-term risk of chronic and end-stage kidney disease after preeclampsia. KIDNEY INTERNATIONAL 2019; 96 (3): 711-727
• Gabrielli G, Paterno A e . Strozza S. Sexual behavioural differences and risk-taking differences among born-abroad and native university students in Italy”, Genus, 76:17, 2020, pp. 1-19. DOI: https://doi.org/10.1186/s41118-020-00088-1 . Open Access Journal
• Versino E, Costa G Salmaso S. Registri e sorveglianze: lacune e prospettive. Epidemiologia&Prevenzione 2015, 39 (2) marzo-aprile

Stress ossidativo e cancro

Azzimonti B, Ballacchino C, Zanetta P, Cucci MA, Monge C, Grattarola M, Dianzani C, Barrera G, Pizzimenti S. (2023) Microbiota, Oxidative Stress, and Skin Cancer: An Unexpected Triangle. Antioxidants (Basel, Switzerland) 12(3) [DOI  PMID]

Argenziano M, Bessone F, Dianzani C, Cucci MA, Grattarola M, Pizzimenti S, Cavalli R. (2022) Ultrasound-Responsive Nrf2-Targeting siRNA-Loaded Nanobubbles for Enhancing the Treatment of Melanoma. Pharmaceutics 14(2) [DOI  PMID]

Pizzimenti S, Ribero S, Cucci MA, Grattarola M, Monge C, Dianzani C, Barrera G, Muzio G. (2021) Oxidative Stress-Related Mechanisms in Melanoma and in the Acquired Resistance to Targeted Therapies. Antioxidants (Basel, Switzerland) 10(12) [DOI  PMID]

Grattarola M, Cucci MA, Roetto A, Dianzani C, Barrera G, Pizzimenti S. (2021) Post-translational down-regulation of Nrf2 and YAP proteins, by targeting deubiquitinases, reduces growth and chemoresistance in pancreatic cancer cells. Free radical biology & medicine 174 202-210 [DOI  PMID]

Barrera G, Cucci MA, Grattarola M, Dianzani C, Muzio G, Pizzimenti S. (2021) Control of Oxidative Stress in Cancer Chemoresistance: Spotlight on Nrf2 Role. Antioxidants (Basel, Switzerland) 10(4) [DOI  PMID]

Ambrosio L, Argenziano M, Cucci MA, Grattarola M, de Graaf IAM, Dianzani C, Barrera G, Sanchez Nieves J, Gomez R, Cavalli R, Pizzimenti S. (2020) Carbosilane Dendrimers Loaded with siRNA Targeting Nrf2 as a Tool to Overcome Cisplatin Chemoresistance in Bladder Cancer Cells. Antioxidants (Basel, Switzerland) 9(10) [DOI  PMID]

Cucci MA, Grattarola M, Dianzani C, Damia G, Ricci F, Roetto A, Trotta F, Barrera G, Pizzimenti S. (2020) Ailanthone increases oxidative stress in CDDP-resistant ovarian and bladder cancer cells by inhibiting of Nrf2 and YAP expression through a post-translational mechanism. Free radical biology & medicine 150 125-135 [DOI  PMID]

 

AGEs and Inflammation in Metabolic Disorders

NEW VIRAL DISEASES AND NEW POSSIBLE REMEDIES THROUGH THE PHARMACOLOGY OF THE RENIN-
2023-01-01 Giovanni Sansoè; https://iris.unito.it/handle/2318/1919950

Anti-inflammatory and anti-glycative properties of zinc-enriched spirulina in diet-induced obese/diabetic mice
2022-01-01 Aimaretti E, Murzio C, Ferreira Alves G, Einaudi G, Collotta D, Porchietto E, Cifani C, Algeri A, Aragno M, Collino M, Mastrocola R https://iris.unito.it/handle/2318/1907200

Different impact of dietary fructose and galactose on metaflammation in rats: protective effects of prebiotic fructooligosaccharydes supplementation
2022-01-01 Mastrocola R, Collotta D, El-Masri F, Murzio C, Aimaretti E, Aragno M, Frank J, Collino M https://iris.unito.it/handle/2318/1907211

ICOS-Fc as innovative immunomodulatory approach to counteract inflammation and organ injury in sepsis
2022-01-01 Alves, Gustavo Ferreira; Stoppa, Ian; Aimaretti, Eleonora; Monge, Chiara; Mastrocola, Raffaella; Porchietto, Elisa; Einaudi, Giacomo; Collotta, Debora; Bertocchi, Ilaria; Boggio, Elena; Gigliotti, Casimiro Luca; Clemente, Nausicaa; Aragno, Manuela; Fernandes, Daniel; Cifani, Carlo; Thiemermann, Christoph; Dianzani, Chiara; Dianzani, Umberto; Collino, Massimo https://iris.unito.it/handle/2318/1876525

Aging, sex and NLRP3 inflammasome in cardiac ischaemic disease
2022-01-01 Alloatti, Giuseppe; Penna, Claudia; Comità, Stefano; Tullio, Francesca; Aragno, Manuela; Biasi, Fiorella; Pagliaro, Pasquale https://iris.unito.it/handle/2318/1881406

Pharmacological Inhibition of FAK-Pyk2 Pathway Protects Against Organ Damage and Prolongs the Survival of Septic Mice
2022-01-01 Alves G.F.; Aimaretti E.; Einaudi G.; Mastrocola R.; de Oliveira J.G.; Collotta D.; Porchietto E.; Aragno M.; Cifani C.; Sordi R.; Thiemermann C.; Fernandes D.; Collino M. https://iris.unito.it/handle/2318/1856357

Advanced glycation end products and their related signaling cascades in adult survivors of childhood Hodgkin lymphoma: A possible role in the onset of late complications
2022-01-01 Felicetti F.; Aimaretti E.; Dal Bello F.; Gatti F.; Godono A.; Saba F.; Einaudi G.; Collino M.; Fagioli F.; Aragno M.; Brignardello E. https://iris.unito.it/handle/2318/1856356

The mitochondrial trigger in an animal model of nonalcoholic fatty liver disease
2021-01-01 Guglielmina Chimienti; Antonella Orlando; Francesco Russo; Benedetta D’Attoma; Manuela Aragno; Eleonora Aimaretti ; Angela Maria Serena Lezza; Vito Pesce https://iris.unito.it/handle/2318/1861221

Altered hepatic sphingolipid metabolism in insulin resistant mice: Role of advanced glycation endproducts
2021-01-01 Mastrocola R.; Dal Bello F.; Cento A.S.; Gaens K.; Collotta D.; Aragno M.; Medana C.; Collino M.; Wouters K.; Schalkwijk C.G. https://iris.unito.it/handle/2318/1789498

Deletion of RAGE fails to prevent hepatosteatosis in obese mice due to impairment of other AGEs receptors and detoxifying systems
2021-01-01 Wouters K.; Cento A.S.; Gaens K.H.; Teunissen M.; Scheijen J.L.J.M.; Barutta F.; Chiazza F.; Collotta D.; Aragno M.; Gruden G.; Collino M.; Schalkwijk C.G.; Mastrocola R. https://iris.unito.it/handle/2318/1802050

COVID-19 and Liver Cirrhosis: Focus on the Nonclassical Renin-Angiotensin System and Implications for Therapy
2021-01-01 Sansoe G.; Aragno M.; Wong F. https://iris.unito.it/handle/2318/1844042

Baricitinib counteracts metaflammation protecting against diet-induced metabolic abnormalities in mice
2020-01-01 Collotta D, Hull W, Mastrocola R, Chiazza F, Cento AS, Murphy C, Verta R, Ferreira Alves G, Gaudioso G, Fava F, Aragno M, Tuohy K, Thiemermann C, Collino M https://iris.unito.it/handle/2318/1789502

Diabetic Cardiomyopathy and Ischemic Heart Disease: Prevention and Therapy by Exercise and Conditioning
2020-01-01 Crisafulli, Antonio; Pagliaro, Pasquale; Roberto, Silvana; Cugusi, Lucia; Mercuro, Giuseppe; Lazou, Antigone; Beauloye, Christophe; Bertrand, Luc; Hausenloy, Derek J; Aragno, Manuela; Penna, Claudia https://iris.unito.it/handle/2318/1737773

Baricitinib counteracts metaflammation, thus protecting against diet-induced metabolic abnormalities in mice
2020-01-01 Collotta D.; Hull W.; Mastrocola R.; Chiazza F.; Cento A.S.; Murphy C.; Verta R.; Alves G.F.; Gaudioso G.; Fava F.; Yaqoob M.; Aragno M.; Tuohy K.; Thiemermann C.; Collino M. https://iris.unito.it/handle/2318/1758975

Effect of hyperglycaemia and diabetes on acute myocardial ischaemia–reperfusion injury and cardioprotection by ischaemic conditioning protocols
2020-01-01 Penna C.; Andreadou I.; Aragno M.; Beauloye C.; Bertrand L.; Lazou A.; Falcao-Pires I.; Bell R.; Zuurbier C.J.; Pagliaro P.; Hausenloy D.J. https://iris.unito.it/handle/2318/1737775

Pathway of hepatic and renal damage through non-classical activation of the renin-angiotensin system in chronic liver disease
2020-01-01 Giovanni Sansoè ; Manuela Aragno ; Florence Wong https://iris.unito.it/handle/2318/1793794

Role of temperature in myocardial ischemic injury and protection by conditioning
2020-01-01 Pasquale Pagliaro, Manuela Aragno, Claudia Penna https://iris.unito.it/handle/2318/1737774

Do P2Y12 receptor antagonism and NLRP3 inhibition exert additive cardioprotective effects against ischemia/reperfusion injury?
2020-01-01 Elisa Zicola, Saveria Femminò, Fausto Chiazza, Debora Collotta, Massimo Collino, Manuela Aragno, Massimo Bertinaria, Pasquale https://iris.unito.it/handle/2318/1872839

Effects of exogenous dietary advanced glycation end products on the cross-talk mechanisms linking microbiota to metabolic inflammation
2020-01-01 Mastrocola R.; Collotta D.; Gaudioso G.; Le Berre M.; Cento A.S.; Ferreira G.A.; Chiazza F.; Verta R.; Bertocchi I.; Manig F.; Hellwig M.; Fava F.; Cifani C.; Aragno M.; Henle T.; Joshi L.; Tuohy K.; Collino M. https://iris.unito.it/handle/2318/1758979

Advanced glycation end products and chronic inflammation in adult survivors of childhood leukemia treated with hematopoietic stem cell transplantation
2020-01-01 Francesco Felicetti, Alessia Sofia Cento, Paolo Fornengo, Maurizio Cassader, Raffaella Mastrocola, Fabrizio D’Ascenzo, Fabio Settanni, Andrea Benso, Emanuela Arvat, Massimo Collino, Franca Fagioli, Manuela Aragno, Enrico Brignardello https://iris.unito.it/handle/2318/1725722

Ticagrelor Conditioning Effects Are Not Additive to Cardioprotection Induced by Direct NLRP3 Inflammasome Inhibition: Role of RISK, NLRP3, and Redox Cascades
2020-01-01 Penna, Claudia; Aragno, Manuela; Cento, Alessia Sofia; Femminò, Saveria; Russo, Isabella; Bello, Federica Dal; Chiazza, Fausto; Collotta, Debora; Alves, Gustavo Ferreira; Bertinaria, Massimo; Zicola, Elisa; Mercurio, Valentina; Medana, Claudio; Collino, Massimo; Pagliaro, Pasquale https://iris.unito.it/handle/2318/1748513

Dietary advanced glycation endproducts in the mechanisms linking proteins glycosylation pattern, microbiota, and metabolic inflammation
2020-01-01 Mastrocola R, Collotta D, Manig F, Verta R, Le Berre M, Fava F, Gaudioso G, Aragno M, Chiazza F, Hellwig M, Gerlach JQ, Tuohy KM, Joshi L, Henle T, Collino M https://iris.unito.it/handle/2318/1789501

Do P2Y12 receptor antagonism and NLRP3 inhibition exert additive cardioprotective effects against ischemia/reperfusion injury?
2019-01-01 Fausto Chiazza, Saveria Femminò, Debora Collotta, Elisa Zicola, Manuela Aragno, Massimo Bertinaria, Pasquale Pagliaro, Claudia Penna, Massimo Collino https://iris.unito.it/handle/2318/1755511

Inhibition of AGEs by pyridoxamine prevents diet-induced systemic inflammation and skeletal muscle insulin resistance by restoring SphK/S1P3/RhoA signalling
2019-01-01 Cento, AS; Collotta, D; Chiazza, F; Aragno, M; Collino, M; Mastrocola, R https://iris.unito.it/handle/2318/1740402

Identification of Annexina1 as an endogenous regulator of RhoA, and its role in the pathophysiology and experimental therapy of type-2 diabetes
2019-01-01 Purvis G.S.D.; Collino M.; Loiola R.A.; Baragetti A.; Chiazza F.; Brovelli M.; Sheikh M.H.; Collotta D.; Cento A.; Mastrocola R.; Aragno M.; Cutrin J.C.; Reutelingsperger C.; Grigore L.; Catapano A.L.; Yaqoob M.M.; Norata G.D.; Solito E.; Thiemermann C. https://iris.unito.it/handle/2318/1723107

SALIVAGE – EU JPI Project
2018-01-01 Liberto E, Cordero C, Mastrocola R, Ferrocino I, Chiazza F, Cento AS, Collotta D, Rantsiou K, https://iris.unito.it/handle/2318/1678782

Genetic deletion of RAGE in Dbdb mice interferes with AGEs receptors and detoxifying systems in liver
2018-01-01 Cento Alessia; https://iris.unito.it/handle/2318/1889881

IMPAIRED SECRETION OF RENALASE INTO BLOOD MAY LEAD TO SYMPATHETIC OVERACTIVITY AND EARLY SODIUM RETENTION IN EXPERIMENTAL LIVER CIRRHOSIS
2018-01-01 Sansoe, G; Aragno, M; Mastrocola, R; Parola, M https://iris.unito.it/handle/2318/1708360

Reduced Susceptibility to Sugar-Induced Metabolic Derangements and Impairments of Myocardial Redox Signaling in Mice Chronically Fed with D-Tagatose when Compared to Fructose
2018-01-01 Collotta, Debora; Lucarini, Laura; Chiazza, Fausto; Cento, Alessia Sofia; Durante, Mariaconcetta; Sgambellone, Silvia; Chini, Jacopo; Baratta, Francesca; Aragno, Manuela; Mastrocola, Raffaella; Masini, Emanuela; Collino, Massimo https://iris.unito.it/handle/2318/1683457

Fructose liquid and solid formulations differently affect gut integrity, microbiota composition and related liver toxicity: a comparative in vivo study
2018-01-01 Mastrocola, Raffaella; Ferrocino, Ilario; Liberto, Erica; Chiazza, Fausto; Cento, Alessia Sofia; Collotta, Debora; Querio, Giulia; Nigro, Debora; Bitonto, Valeria; Cutrin, Juan Carlos; Rantsiou, Kalliopi; Durante, Mariaconcetta; Masini, Emanuela; Aragno, Manuela; Cordero, Chiara; Cocolin, Luca; Collino, Massimo https://iris.unito.it/handle/2318/1661849

Metaflammation: tissue-specific alterations of the NLRP3 inflammasome platform
2018-01-01 Mastrocola, Raffaella; Aragno, Manuela; Alloatti, Giuseppe; Collino, Massimo; Penna, Claudia; Pagliaro, Pasquale https://iris.unito.it/handle/2318/1634181

TISSUE RENIN-ANGIOTENSIN SYSTEM IN THE KIDNEY OF ASCITIC CIRRHOSIS: AN INNOCENT BYSTANDER OR A PROTAGONIST?
2018-01-01 Sansoe, G; Aragno, M; Mastrocola, R; Parola, M https://iris.unito.it/handle/2318/1708364

IN EXPERIMENTAL ASCITIC CIRRHOSIS REDUCTION OF ADRENERGIC FUNCTION HAS CONSIDERABLE AQUARETIC EFFECTS: PATHOPHYSIOLOGICAL AND CLINICAL CONSEQUENCES
2018-01-01 Sansoe, G; Aragno, M; Mastrocola, R; Parola, M https://iris.unito.it/handle/2318/1708363

AGEs induce alterations of sphingolipids metabolism in the liver of genetically- and diet-induced diabetic mice
2018-01-01 Cento, AS; Gaens, K; Collotta, D; Chiazza, F; Barutta, F; Scheijen, J; Aragno, M; Collino, M; Wouters, K; Schalkwijk, CG; Mastrocola, R https://iris.unito.it/handle/2318/1740097

Stable Oxidative Cytosine Modifications Accumulate in Cardiac Mesenchymal Cells from Type2 Diabetes Patients: Rescue by alpha Ketoglutarate and TET-TDG Functional Reactivation
2018-01-01 Spallotta, Francesco; Cencioni, Chiara; Atlante, Sandra; Garella, Davide; Cocco, Mattia; Mori, Mattia; Mastrocola, Raffaella; Kuenne, Carsten; Guenther, Stefan; Nanni, Simona; Azzimato, Valerio; Zukunft, Sven; Kornberger, Angela; Sã¼rã¼n, Duran; Schnã¼tgen, Frank; Von Melchner, Harald; Di Stilo, Antonella; Aragno, Manuela; Braspenning, Maarten; Van Criekinge, Wim; De Blasio, Miles J.; Ritchie, Rebecca H.; Zaccagnini, Germana; Martelli, Fabio; Farsetti, Antonella; Fleming, Ingrid; Braun, Thomas; Beiras-Fernandez, Andres; Botta, Bruno; Collino, Massimo; Bertinaria, Massimo; Zeiher, Andreas M.; Gaetano, Carlo https://iris.unito.it/handle/2318/1657432

Genetic deletion of RAGE in db/db mice interferes in the liver with other AGE-receptors and AGE-detoxifying systems sustaining lipogenesis and inflammation
2018-01-01 Mastrocola, R; Cento, AS; Collotta, D; Chiazza, F; Barutta, F; Scheijen, J; Aragno, M; Gaens, K; Collino, M; Schalkwijk, CG; Wouters, K https://iris.unito.it/handle/2318/1740098

Effects of Vitamin D on insulin resistance and myosteatosis in diet-induced obese mice
2018-01-01 Benetti, Elisa*; Mastrocola, Raffaella; Chiazza, Fausto; Nigro, Debora; D’Antona, Giuseppe; Bordano, null; Fantozzi, Roberto; Aragno, Manuela; Collino, Massimo; Minetto, Marco Alessandro https://iris.unito.it/handle/2318/1660078

Toxicological impact of high fructose intake on gut microbiota and liver/intestine integrity: Any differences between solid and liquid formulations?
2017-01-01 Mastrocola, R; Cento, As; Chiazza, F; Ferrocino, I; Bitonto, V; Nigro, D; Querio, G; Rantsiou, K; Cutrin, Jc; Aragno, M; Liberto, E; Masini, E; Cordero, C; Cocolin, L; Collino, M. https://iris.unito.it/handle/2318/1657437

Local renin–angiotensin system in the kidney of ascitic cirrhosis: An innocent bystander or a major protagonist?
2017-01-01 Sansoè, G.; Aragno, M.; Mastrocola, R.; Ayoubi, M.; Parola, M. https://iris.unito.it/handle/2318/1708368

Dietary sugars and endogenous formation of advanced glycation endproducts: Emerging mechanisms of disease
2017-01-01 Aragno, Manuela; Mastrocola, Raffaella https://iris.unito.it/handle/2318/1641649

In experimental liver cirrhosis impaired secretion of renalase into blood may lead to organ damage and sympathetic overactivity
2017-01-01 Sansoè, G.; Aragno, M.; Mastrocola, R.; Ayoubi, M.; Parola, M. https://iris.unito.it/handle/2318/1708371

Protective Effects of Pyridoxamine Supplementation in the Early Stages of Diet-Induced Kidney Dysfunction
2017-01-01 Chiazza, F; Cento, A. S; Collotta, D; Nigro, D; Rosa, G; Baratta, F; Bitonto, V; Cutrin, J. C; Aragno, M; Mastrocola, R; Collino, M. https://iris.unito.it/handle/2318/1657424

In experimental ascitic cirrhosis reduction of adrenergic function by means of α2A adrenergic receptor agonists has considerable aquaretic effects
2017-01-01 Sansoè, G.; Aragno, M.; Mastrocola, R.; Ayoubi, M.; Parola, M. https://iris.unito.it/handle/2318/1708372

Effects of chronic sugar consumption on lipid accumulation and autophagy in the skeletal muscle
2017-01-01 de Stefanis, Daniela; Mastrocola, Raffaella; Nigro, Debora; Costelli, Paola; Aragno, Manuela https://iris.unito.it/handle/2318/1528854

Considerable aquaretic effects in experimental ascitic cirrhosis achieved through blunting of adrenergic function with α2A adrenergic receptor agonists
2017-01-01 Sansoe’, G.; Aragno, M.; Mastrocola, R.; Ayoubi, M.; Parola, M. https://iris.unito.it/handle/2318/1708377

Chronic administration of saturated fats and fructose differently affect SREBP activity resulting in different modulation of Nrf2 and Nlrp3 inflammasome pathways in mice liver
2017-01-01 Nigro, Debora; Menotti, Francesca; Cento, Alessia S; Serpe, Loredana; Chiazza, Fausto; Dal Bello, Federica; Romaniello, Francesco; Medana, Claudio; Collino, Massimo; Aragno, Manuela; Mastrocola, Raffaella https://iris.unito.it/handle/2318/1624845

The AGEs inhibitor pyridoxamine prevents kidney injury and dysfunction in mice fed high-fat high-fructose diet
2017-01-01 Collino, M; Chiazza, F; Collotta, D; Cento, As; Nigro, D; Bitonto, V; Cutrin, Jc; Aragno, M; Mastrocola, R. https://iris.unito.it/handle/2318/1657438

Advanced Glycation End Products Inhibition Restores Sphingolipid Rheostat in Mice Liver and Prevents Diet-Induced Insulin Resistance
2016-01-01 Cento, Alessia Sofia; Nigro, Debora; Chiazza, Fausto; Dal Bello, Federica; Romaniello, Francesco; Collino, Massimo; Medana, Claudio; Aragno, Manuela; Mastrocola, Raffaella https://iris.unito.it/handle/2318/1630474

Cardiac Epi-Metabolic Signature Revealed by Integrated Omics Approach in Diabetic Patients: Rescue by Active DNA Demethylation via TET-TDG Complex Reactivation
2016-01-01 Spallotta, F; Cencioni, C; Atlante, S; Garella, D; Cocco, M; Mori, M; Mastrocola, R; Kuenne, C; Guenther, S; Nanni, S; Azzimato, V; Zukunft, S; Kornberger, A; Di Stilo, A; Aragno, M; Martelli, F; Farsetti, A; Fleming, I; Braun, T; Beiras-Fernandez, A; Botta, B; Collino, M; Bertinaria, M; Zeiher, Am; Gaetano, C. https://iris.unito.it/handle/2318/1657445

Pathogenesis of Solute-Free Water Retention in Experimental Ascitic Cirrhosis: Is Vasopressin the Only Culprit?
2016-01-01 Sansoe', Giovanni; Aragno, Manuela; Mastrocola, Raffaella; Parola, Maurizio https://iris.unito.it/handle/2318/1528853

Alpha-2A Adrenoceptor Agonist Guanfacine Restores Diuretic Efficiency in Experimental Cirrhotic Ascites: Comparison with Clonidine
2016-01-01 Sansoè, Giovanni; Aragno, Manuela; Mastrocola, Raffaella; Mengozzi, Giulio; Parola, Maurizio https://iris.unito.it/handle/2318/1585320

Maladaptive Modulations of NLRP3 Inflammasome and Cardioprotective Pathways Are Involved in Diet-Induced Exacerbation of Myocardial Ischemia/Reperfusion Injury in Mice
2016-01-01 Mastrocola, Raffaella; Collino, Massimo; Penna, Claudia; Nigro, Debora; Chiazza, Fausto; Fracasso, Veronica; Tullio, Francesca; Alloatti, Giuseppe; Pagliaro, Pasquale; Aragno, Manuela https://iris.unito.it/handle/2318/1545358

Role of Chymase in the Development of Liver Cirrhosis and Its Complications: Experimental and Human Data
2016-01-01 Sansoè, Giovanni; Aragno, Manuela; Mastrocola, Raffaella; Mengozzi, Giulio; Novo, Erica; Parola, Maurizio https://iris.unito.it/handle/2318/1598612

Fructose-derived advanced glycation end-products drive lipogenesis and skeletal muscle reprogramming via SREBP-1c dysregulation in mice
2016-01-01 Mastrocola, R; Nigro, D; Chiazza, F; Medana, C; Dal Bello, F; Boccuzzi, G; Collino, M; Aragno, M https://iris.unito.it/handle/2318/1542011

Pharmacological inhibition of NLRP3 inflammasome attenuates myocardial ischemia/reperfusion injury by activation of RISK and mitochondrial pathways
2016-01-01 Mastrocola, Raffaella; Penna, Claudia; Tullio, Francesca; Femminò, Saveria; Nigro, Debora; Chiazza, Fausto; Serpe, Loredana; Collotta, Debora; Alloatti, Giuseppe; Cocco, Mattia; Bertinaria, Massimo; Pagliaro, Pasquale; Aragno, Manuela; Collino, Massimo https://iris.unito.it/handle/2318/1624808

Dose-dependecy of clonidine's effects in ascitic cirrhotic rats: Comparison with α1-adrenergic agonist midodrine.
2016-01-01 Sansoè, G; Aragno, M; Mastrocola, R; Parola, M2. https://iris.unito.it/handle/2318/1521213

High-fructose intake as risk factor for neurodegeneration: Key role for carboxy methyllysine accumulation in mice hippocampal neurons
2016-01-01 Mastrocola, Raffaella; Nigro, Debora; Cento, Alessia S; Chiazza, Fausto; Collino, Massimo; Aragno, Manuela https://iris.unito.it/handle/2318/1554565

Pyridoxamine prevents diet-induced insulin resistance through the regulation of ceramide/sphingosine/sphingosine-1-phosphate equilibrium in mice liver
2016-01-01 Mastrocola, R; Nigro, D; Cento, As; Schiano, G; Chiazza, F; Dal Bello, F; Romaniello, F; Collino, M; Medana, C; Aragno, M. https://iris.unito.it/handle/2318/1625266

Fructose-derived advanced glycation end-products induce a negative crosstalk between lipogenesis and muscle reprogramming in mice through SREBP-1c
2015-01-01 Mastrocola R; Collino M; Nigro D; Medana C; Dal Bello F; Chiazza F; Boccuzzi G; Aragno M. https://iris.unito.it/handle/2318/1525579

Targeting the NLRP3 inflammasome to reduce diet-induced metabolic abnormalities in mice
2015-01-01 Chiazza, Fausto; Couturier-Maillard, Aurélie; Benetti, Elisa; Mastrocola, Raffaella; Nigro, Debora; Cutrin, Juan C; Serpe, Loredana; Aragno, Manuela; Fantozzi, Roberto; Ryffel, Bernard; Thiemermann, Christoph; Collino, Massimo https://iris.unito.it/handle/2318/1550762

Accumulation of Advanced Glycation End-Products and Activation of the SCAP/SREBP Lipogenetic Pathway Occur in Diet-Induced Obese Mouse Skeletal Muscle.
2015-01-01 Mastrocola R; Collino M; Nigro D; Chiazza F; D'Antona G; Aragno M; Minetto MA https://iris.unito.it/handle/2318/157075

Is NLRP3 inflammasome a new pharmacological target in myocardial ischemia/reperfusion injury?
2015-01-01 Femminò, S; Chiazza, F; Mastrocola, R; Tullio, F; Penna, C; Nigro, D; Alloatti, G; Cocco, M; Garella, D; Bertinaria, M; Fantozzi, R; Aragno, M; Collino, M; Pagliaro, P https://iris.unito.it/handle/2318/1563302

Exacerbation of myocardial ischemia/reperfusion injury induced by high-fat-high-fructose (HFHF) diet: Role of NLRP3 inflammasome
2015-01-01 Tullio, F.; Chiazza, F.; Mastrocola, R.; Penna, C.; Nigro, D.; Fracasso, V.; Alloatti, G.; Fantozzi, R.; Aragno, M.; Collino, M.; Pagliaro, P. https://iris.unito.it/handle/2318/1563309

A non-erythropoietic peptide derivative of erythropoietin decreases susceptibility to diet-induced insulin resistance in mice
2014-01-01 M Collino;E Benetti;M Rogazzo;F Chiazza;R Mastrocola;D Nigro;J C Cutrin;M Aragno;R Fantozzi;M A Minetto;C Thiemermann https://iris.unito.it/handle/2318/154526

Variability in myosteatosis and insulin resistance induced by high-fat diet in mouse skeletal muscles.
2014-01-01 Collino M;Mastrocola R;Nigro D;Chiazza F;Aragno M;D'Antona G;Minetto MA https://iris.unito.it/handle/2318/149879

Fructose-Derived Advanced Glycation End-Products Evoke Skeletal Muscle Damage in Mice by Multiple Interference with SCAP-SREBP Pathway
2014-01-01 Raffaella Mastrocola;Debora Nigro;Fausto Chiazza;Massimo Collino;Manuela Aragno https://iris.unito.it/handle/2318/150148

A LIPIDOMIC STUDY OF HIGH-FAT DIET TREATED MICE.
2014-01-01 Federica Dal Bello; Valentina Santoro; Manuela Aragno; Raffaella Mastrocola; Claudio Medana; Claudio Baiocchi. https://iris.unito.it/handle/2318/153711

Dynamics of sodium retention in preascitic cirrhotic rats assessed through parathyroid hormone injection.
2014-01-01 Sansoe G;Mastrocola R;Aragno M;Parola M https://iris.unito.it/handle/2318/150150

Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR- agonism correlates with impaired NLRP3 inflammasome activation
2013-01-01 Massimo Collino; Elisa Benetti; Mara Rogazzo; Raffaella Mastrocola; Muhammed M. Yaqoob; Manuela Aragno; Christoph Thiemermann; Roberto Fantozzi https://iris.unito.it/handle/2318/119475

A nonerythropoietic peptide analog of erythropoietin decreases susceptibility to diet-induced insulin resistance
2013-01-01 E. Benetti; M. Collino; M. Rogazzo; F. Chiazza; R. Mastrocola; M. Aragno; M. Minetto; C. Thiemermann; R. Fantozzi https://iris.unito.it/handle/2318/144592

Inflammatory signaling and insulin resistance caused by sugar intake: modulation by PPAR-δ agonism
2013-01-01 M. Rogazzo; M. Collino; E. Benetti; F. Chiazza; R. Mastrocola; M. Minetto; M. Aragno; C. Thiemermann; R. Fantozzi. https://iris.unito.it/handle/2318/144597

Multiple courses of G-CSF in patients with decompensated cirrosi: consistent mobilization of immature cells ex pressing hepatocyte markers and exploratory clinical evaluation.
2013-01-01 Gaia S; Olivero A; Smedile A; Ruella M; Abate ML; Fadda M; Rolle E; Omdé P; Bondesan P; Passera r; Risso A; Aragno M; Marzano A; Ciancio A; Rizzetto M; Tarella C. https://iris.unito.it/handle/2318/154133

Calcium receptors located in fibrotic septa: a new target to reduce portal pressure in liver cirrhosis
2013-01-01 Giovanni Sansoè;Manuela Aragno;Raffaella Mastrocola;Claudia Paternostro;Maurizio Parola https://iris.unito.it/handle/2318/130145

High Sugar Intake and Development of Skeletal Muscle Insulin Resistance and Inflammation in Mice: A Protective Role for PPAR- δ Agonism.
2013-01-01 Benetti E;Mastrocola R;Rogazzo M;Chiazza F;Aragno M;Fantozzi R;Collino M;Minetto MA https://iris.unito.it/handle/2318/138588

Advanced glycation end-products promote hepatosteatosis by interfering with SCAP-SREBP pathway in fructose drinking mice
2013-01-01 Mastrocola R; Collino M; Rogazzo M; Medana C; Nigro D; Boccuzzi G; Aragno M. https://iris.unito.it/handle/2318/138695

Study of the photocatalytic transformation of synephrine: a biogenic amine relevant in anti-doping analysis
2013-01-01 C.Medana;P. Calza;V. Giancotti;F. Dal Bello;M. Aragno;C. Baiocchi https://iris.unito.it/handle/2318/141890

Inhibition of chymase-dependent production of kidney angiotensin II improves renal sodium handling and prevents ascites in experimental liver cirrhosis
2012-01-01 Sansoè G; Aragno M; Mastrocola R; Mengozzi G; Novo E; Smedile A; Parola M; Rizzetto M. https://iris.unito.it/handle/2318/99931

Key role of chymase in the hepatic production of angiotensin II and in the development of experimental liver cirrhosis and its complications.
2012-01-01 Sansoè G; Aragno M; Mastrocola R; Mengozzi G; Paternostro C; Smedile A; Rizzetto M; Parola M. https://iris.unito.it/handle/2318/99930

Obestatin induced recovery of myocardial dysfunction in type 1 diabetic rats: underlying mechanisms.
2012-01-01 Aragno M; Mastrocola R; Ghé C; Arnoletti E; Bassino E; Alloatti G; Muccioli G. https://iris.unito.it/handle/2318/125766

Advanced Glycation End-Products Promote Lipogenesis in Liver of Fructose-Drinking Mice
2012-01-01 Mastrocola R; Collino M; Nigro D; Medana C; Aragno M. https://iris.unito.it/handle/2318/127265

Key role of chymase in the hepatic production of angiotensin II and in the development of experimental liver cirrhosis and its complications.
2012-01-01 Sansoè G; Aragno M; Mastrocola R; Mengozzi G; Paternostro C; Smedile A; Rizzetto M; Parola M. https://iris.unito.it/handle/2318/101458

Inhibition of chymase-dependent production of kidney angiotensin II improves renal sodium handling and prevents ascites in experimental liver cirrhosis
2012-01-01 Sansoè G; Aragno M; Mastrocola R; Mengozzi G; Novo E; Smedile A; Parola M; Rizzetto M. https://iris.unito.it/handle/2318/99720

High-fructose corn syrup (HFCS) diet induces an NLRP-3 inflammasome-mediated response in the kidney: protection by PPARb/d agonist
2012-01-01 E. Benetti; M. Collino; M. Rogazzo; M. Aragno; R. Mastrocola; R. Fantozzi https://iris.unito.it/handle/2318/121570

Effect of n-3 fatty acids on patients with advanced lung cancer: a double-blind, placebo-controlled study.
2012-01-01 Finocchiaro C;Segre O;Fadda M;Monge T;Scigliano M;Schena M;Tinivella M;Tiozzo E;Catalano MG;Pugliese M;Fortunati N;Aragno M;Muzio G;Maggiora M;Oraldi M;Canuto RA https://iris.unito.it/handle/2318/131008

AGEs/RAGE complex upregulates BACE1 via NF-kappaB pathway activation
2012-01-01 Guglielmotto M; Aragno M; Tamagno E; Vercellinatto I; Visentin S; Medana C; Catalano MG; Smith MA; Perry G; Danni O; Boccuzzi G; Tabaton M. https://iris.unito.it/handle/2318/81738

Dysregulation of SREBP2 induces BACE1 expression.
2011-01-01 R. Mastrocola;M. Guglielmotto;C. Medana;M. G. Catalano;S. Cutrupi;R. Borghi;E. Tamagno;G. Boccuzzi;M. Aragno https://iris.unito.it/handle/2318/154655

Advanced glycation end products (AGEs) as pathology biomarkers: microwave assisted synthesis and biological quantitative analysis by LC-FTMS
2011-01-01 C. Medana; S. Visentin; F. Dal Bello; V. Giancotti; R. Mastrocola ; M. Aragno; C. Baiocchi https://iris.unito.it/handle/2318/99837

Peroxisome proliferator-activated receptor β/δ agonism protects the kidney against ischemia/reperfusion injury in diabetic rats.
2011-01-01 Collino M; Benetti E; Miglio G; Castiglia S; Rosa AC; Aragno M; Thiemermann C; Fantozzi R. https://iris.unito.it/handle/2318/81551

Pioglitazone improves lipid and insulin levels in overweight rats on a high cholesterol and fructose diet by decreasing hepatic inflammation.
2010-01-01 Collino M; Aragno M; Castiglia S; Miglio G; Tomasinelli C; Boccuzzi G; Thiemermann C; Fantozzi R. https://iris.unito.it/handle/2318/99870

Liver cirrhosis and intrahepatic rennin-angiotensin system: a reappraisal.
2010-01-01 Sansoé G; Aragno M; Tomasinelli CE; Mastrocola R; Parola M https://iris.unito.it/handle/2318/84275

Receptors of calcium and calcimimetic agents inside the cirrotic liver are new targets to reduce portal pressure.
2010-01-01 Sansoè G;Aragno M; Tommasinelli C.E; Parola M. https://iris.unito.it/handle/2318/83052

Free-water retention occurs in experimental preascitic liver cirrosi and is influenced by extracellular calcium.
2010-01-01 Sansoé G; Aragno M; Mastrocola R; Parola M https://iris.unito.it/handle/2318/84274

Hypercholesterolemia and Risk of Alzheimer's Disease: a New Role for the Cholesterogenic Factor SREBP2
2010-01-01 Mastrocola R; Guglielmotto M; Tamagno E; Danni O; Aragno M. https://iris.unito.it/handle/2318/87696

AGEs up-regulates BACE1 through their interaction with RAGE and NFkB activation.
2010-01-01 Guglielmotto M; Mastrocola R; Aragno M; Tamagno E; Danni O; Boccuzzi G; Tabaton M. https://iris.unito.it/handle/2318/87697

Thiamine protects the kidney against the injury and dysfunction caused by ischaemia reperfusion by multiple mechanisms
2010-01-01 Memon S; Kieswich J; Allen D; James A; Patel N; Raftery M; Thiemermann C; Yaqoob M; Collino M; Aragno M; Fantozzi R; Castiglia S; Cuzzocrea S; Mazzon E https://iris.unito.it/handle/2318/127596

Biomolecular expression of target receptors of calcimimetic agents in experimental liver cirrhosis: a new strategy to reduce portal pressure.
2010-01-01 Sansoè G; Aragno M; Tomasinelli C; Valfrè di Bonzo L; Parola M; Smedile A; Rizzetto M. https://iris.unito.it/handle/2318/75983

Identification of the Henle’s loop as a major site of sodium retention in experimental pre-ascitic cirrhosis: effects of parathyroid hormone
2010-01-01 Sansoè G; Aragno M; Novo E; Mastrocola R; Parola M. https://iris.unito.it/handle/2318/75910

Intrahepatic renin-angiotensin system and liver cirrhosis: an updated reappraisal.
2010-01-01 Sansoè G; Aragno M; Tomasinelli C; Mastrocola R; Parola M. https://iris.unito.it/handle/2318/75984

Calcium-dependent diuretic system in preascitic liver cirrhosis.
2010-01-01 Sansoè G; Aragno M; Tomasinelli CE; di Bonzo LV; Wong F; Parola M. https://iris.unito.it/handle/2318/129813

Mitochondrial DNA copy number and citrate synthase activity in nonalcoholic fatty liver disease induced in rats by a high-fat plus fructose diet fortified or not with dehydroepiandrosterone (DHEA)
2009-01-01 Lezza AMS; Cassano P; Mastrocola R; Pesce V; Aragno M; Gadaleta MN https://iris.unito.it/handle/2318/1625596

Cardiovascular Physiology

PUBBLICAZIONI/PUBLICATIONS

1. Zicola E, Arrigo E, Mancardi D. H₂S Pretreatment Is Promigratory and Decreases Ischemia/Reperfusion Injury in Human Microvascular Endothelial Cells. Oxid Med Cell Longev. 2021 Apr 15;2021:8886666. doi: 10.1155/2021/8886666.
2. Folino A, Accomasso L, Giachino C, Montarolo PG, Losano G, Pagliaro P, Rastaldo R. Apelin-induced cardioprotection against ischaemia/reperfusion injury: roles of epidermal growth factor and Src. Acta Physiol (Oxf). 2018 Feb;222(2). doi: 10.1111/apha.12924.
3. Penna C, Femminò S, Caldera F, Rubin Pedrazzo A, Cecone C, Alfì E, Comità S, Higashiyama T, Trotta F, Pagliaro P, Cavalli R. Cyclic Nigerosyl-Nigerose as Oxygen Nanocarrier to Protect Cellular Models from Hypoxia/Reoxygenation Injury: Implications from an In Vitro Model. Int J Mol Sci. 2021 Apr 19;22(8):4208. doi: 10.3390/ijms22084208.
4. Penna C, Sorge M, Tullio F, Comità S, Femminò S, Brancaccio M, Pagliaro P. A TRICk to Improve the Effectiveness of RIC: Role of Limb Temperature in Enhancing the Effectiveness of Remote Ischemic Conditioning. Biology (Basel). 2022 Jan 17;11(1):146. doi: 10.3390/biology11010146. PMID: 35053144; PMCID: PMC8773203.
5. D'Ascenzo F, Femminò S, Ravera F, Angelini F, Caccioppo A, Franchin L, Grosso A, Comità S, Cavallari C, Penna C, De Ferrari GM, Camussi G, Pagliaro P, Brizzi MF. Extracellular vesicles from patients with Acute Coronary Syndrome impact on ischemia-reperfusion injury. Pharmacol Res. 2021 Aug;170:105715. doi: 10.1016/j.phrs.2021.105715.

Cell Biology

– mTORC2 Is Activated under Hypoxia and Could Support Chronic Myeloid Leukemia Stem Cells.Panuzzo C, Pironi L, Maglione A, Rocco S, Stanga S, Riganti C, Kopecka J, Ali MS, Pergolizzi B, Bracco E, Cilloni D. Int J Mol Sci. 2023 Jan 8;24(2):1234. doi: 10.3390/ijms24021234.

– Revealing the Mysteries of Acute Myeloid Leukemia: From Quantitative PCR through Next-Generation Sequencing and Systemic Metabolomic Profiling
2022-01-01 Panuzzo C.; Jovanovski A.; Ali M.S.; Cilloni D.; Pergolizzi B. https://iris.unito.it/handle/2318/1875882

– Present and Future Opportunities in Imaging the Ubiquitin System (Ub-System)
2022-01-01 Mortati, Leonardo; Pergolizzi, Barbara; Panuzzo, Cristina; Bracco, Enrico https://iris.unito.it/handle/2318/1877485

– Study of PIA/Rictor Protein Stability using both Dictyostelium discoideum and
2022-01-01 Cristina Panuzzo, Simone Rocco, Enrico Bracco, Barbara Pergolizzi https://iris.unito.it/handle/2318/1875921

– Escaping from hypoxia to enjoy normoxia: insights from the social amoeba
2022-01-01 Barbara Pergolizzi, Marta Biondo, Cristina Panuzzo, Simone Rocco, Matteo https://iris.unito.it/handle/2318/1875922

– The dynamics of the directed migration in response to oxygen gradient
2021-01-01 Barbara Pergolizzi, Marta Biondo, Cristina Panuzzo, M. Shahzad Ali, Matteo Osella, Enrico Bracco. https://iris.unito.it/handle/2318/1875944

– Ali MS, Panuzzo C, Calabrese C, Maglione A, Piazza R, Cilloni D, Saglio G, Pergolizzi B & Bracco E. The Giant HECT E3 Ubiquitin Ligase HERC1 Is Aberrantly Expressed in Myeloid Related Disorders and It Is a Novel BCR-ABL1 Binding Partner. Cancers (Basel). 2021 Jan 19;13(2):341. doi: 10.3390/cancers13020341. PMID: 33477751; PMCID: PMC7832311.

– Ali MS, Magnati S, Panuzzo C, Cilloni D, Saglio G, Pergolizzi B & Bracco E. The Downregulation of Both Giant HERCs, <i>HERC1</i> and <i>HERC2</i>, Is an Unambiguous Feature of Chronic Myeloid Leukemia, and HERC1 Levels Are Associated with Leukemic Cell Differentiation. J Clin Med. 2022 Jan 10;11(2):324. doi: 10.3390/jcm11020324. PMID: 35054018; PMCID: PMC8778248.

– Pergolizzi B, Bozzaro S, Bracco E. Dictyostelium as model for studying ubiquitination and deubiquitination. Int J Dev Biol. 2019;63(8-9-10):529-539. doi: 10.1387/ijdb.190260eb. PMID: 31840790.

– Pergolizzi B, Bracco E, Bozzaro S. A new HECT ubiquitin ligase regulating chemotaxis and development in Dictyostelium discoideum. J Cell Sci. 2017 Feb 1;130(3):551-562. doi: 10.1242/jcs.194225. Epub 2017 Jan 3. PMID: 28049717.

– Pergolizzi B, Bozzaro S, Bracco E. G-Protein Dependent Signal Transduction and Ubiquitination in Dictyostelium. Int J Mol Sci. 2017 Oct 19;18(10):2180. doi: 10.3390/ijms18102180. PMID: 29048338; PMCID: PMC5666861.

Molecular Virology and Antiviral Research

Publications/Pubblicazioni

Pharmacology

PUBLICATIONS/PUBBLICAZIONI

Rheumatology

Pubblicazioni/Publications

1. Novel and reliable DACTylitis glObal Sonographic (DACTOS) score in psoriatic arthritis. Zabotti A, Sakellariou G, Tinazzi I, Idolazzi L, Batticciotto A, Canzoni M, Carrara G, De Lucia O, Figus F, Girolimetto N, Macchioni P, McConnell R, Possemato N, Iagnocco A. Ann Rheum Dis. 2020;79:1037-43
2. The predictive role of ultrasound-detected tenosynovitis and joint synovitis for flare in patients with rheumatoid arthritis in stable remission. Results of an Italian multicentre study of the Italian Society for Rheumatology Group for Ultrasound: the STARTER study. Filippou G, Sakellariou G, Scirè CA, Carrara G, Rumi F, Bellis E, Adinolfi A, Batticciotto A, Bortoluzzi A, Cagnotto G, Caprioli M, Canzoni M, Cavatorta FP, De Lucia O, Di Sabatino V, Draghessi A, Farina I, Focherini MC, Gabba A, Gutierrez M, Idolazzi L, Luccioli F, Macchioni Pi, Massarotti MS, Mastaglio C, Menza L, Muratore M, Parisi S, Picerno V, Piga M, Ramonda R, Raffeiner B, Rossi D, Rossi S, Rossini P, Scioscia C, Venditti C, Volpe A, Iagnocco A. Ann Rheum Dis 2018; 77:1283-89
3. Identification of calcium pyrophosphate deposition disease (CPPD) by ultrasound: reliability of the OMERACT definitions in an extended set of joints-an international multiobserver study by the OMERACT Calcium Pyrophosphate Deposition Disease Ultrasound Subtask Force. Filippou G, Scirè CA, Adinolfi A, Damjanov NS, Carrara G, Bruyn GAW, Cazenave T, D'Agostino MA, Delle Sedie A, Di Sabatino V, Diaz Cortes ME, Filippucci E, Gandjbakhch F, Gutierrez M, Maccarter DK, Micu M, Möller Parera I, Mouterde G, Mortada MA, Naredo E, Pineda C, Porta F, Reginato AM, Satulu I,  Schmidt WA, Serban T, Terslev L, Vlad V, Vreju FA, Zufferey P, Bozios P, Toscano C, Picerno V, Iagnocco Ann Rheum Dis 2018; 77:1194-1199
4. EULAR recommendations for the use of imaging in the clinical management of peripheral joint osteoarthritis. Sakellariou G, Conaghan PG, Zhang W,  Bijlsma JWJ, Boyesen P, D'Agostino MA, Doherty M, Fodor D,  Kloppenburg M, Miese F, Naredo E, Porcheret M, Iagnocco A. Ann Rheum Dis 2017;76:1484-94
5. An OMERACT reliability exercise of inflammatory and structural abnormalities in patients with knee osteoarthritis using ultrasound assessment. AW Bruyn G, Naredo E, Damjanov N, Bachta A, Baudoin P, Hammer HB, Lamers-Karnebeek FBg, Moller Parera I, Richards B, Taylor M, Ben-Artzi A, D'Agostino MA, Garrido J, Iagnocco Ann Rheum Dis 2016; 75:842-6