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Coronavirus: aggiornamenti per la comunità universitaria / Coronavirus: updates for UniTo Community

Applied Biology

1. Goitre L, DiStefano PV, Moglia A, Nobiletti N, Baldini E, Trabalzini L, Keubel J, Trapani E, Shuvaev VV, Muzykantov VR, Sarelius IH, Retta SF* & Glading AJ. (2017). Up-regulation of NADPH oxidase-mediated redox signaling contributes to the loss of barrier function in KRIT1 deficient endothelium. Scientific Reports, 2017 Aug 15;7(1):8296.

2. Retta SF* and Glading AJ. (2016). Oxidative stress and inflammation in cerebral cavernous malformation disease pathogenesis: Two sides of the same coin. International Journal of Biochemistry & Cell Biolology, 2016 Dec; 81(Pt B):254-270.

3. Choquet H, Trapani E, Goitre L, Trabalzini L, Akers A., Fontanella M, Hart BL, Morrison LA, Pawlikowska L, Kim H, Retta SF*. (2016). Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in Cerebral Cavernous Malformation type 1. Free Radical Biology and Medicine, 2016 Jan 19;92:100-109.

4. Marchi S, Corricelli M, Trapani E, Bravi L, Pittaro A, Delle Monache S, Ferroni L, Patergnani S, Missiroli S, Goitre L, Trabalzini L, Rimessi A, Giorgi C, Zavan B, Cassoni P, Dejana E, Retta SF*, Pinton P. (2015). Defective autophagy is a key feature of cerebral cavernous malformations. EMBO Molecular Medicine, 2015. 7(11):1403-1417.

5. Goitre L, De Luca E, Braggion S, Trapani E, Guglielmotto M, Biasi F, Forni M, Moglia A, Trabalzini L, Retta SF*. (2014) KRIT1 loss of function causes a ROS-dependent upregulation of c-Jun. Free Radical Biology and Medicine, 2014 Mar; 68:134-47.

 

Biostatistica

Berchialla, P., Sciannameo, V., Urru, S., Lanera, C., Azzolina, D., Gregori, D., & Baldi, I. (2021). Adjustment for baseline covariates to increase efficiency in RCTs with binary endpoint: A comparison of Bayesian and frequentist approaches. International Journal of Environmental Research and Public Health, 18(15). https://doi.org/10.3390/ijerph18157758

Sciannameo, V., Berchialla, P., Avogaro, A., Fadini, G. P., & Network, D.‑ (2021). Transposition of cardiovascular outcome trial effects to the real‑world population of patients with type 2 diabetes. Cardiovascular Diabetology, 20(1), 103. https://doi.org/10.1186/s12933-021-01300-y

Berchialla, P., Chiffi, D., Valente, G., & Voutilainen, A. (2021). The power of meta‑analysis: A challenge for evidence‑based medicine. European Journal for Philosophy of Science, 11(1). https://doi.org/10.1007/s13194-020-00321-w

Berchialla, P., Zohar, S., & Baldi, I. (2019). Bayesian sample size determination for phase IIA clinical trials using historical data and semi‑parametric prior’s elicitation. Pharmaceutical Statistics, 18(2), 198–211 https://doi.org/10.1002/pst.1914

Lanera, C., Berchialla, P., Sharma, A., Minto, C., Gregori, D., & Baldi, I. (2019). Screening PubMed abstracts: Is class imbalance always a challenge to machine learning? Systematic Reviews, 8(1). https://doi.org/10.1186/s13643-019-1245-8

Cancer cachexia

PUBLICATIONS

  • Pin, M. Beltrà, L. García-Castillo, B. Pardini, G. Birolo, G. Matullo, F. Penna, D. Guttridge, P. Costelli (2022). Extracellular vesicles derived from tumor cells as a trigger of energy default in the skeletal muscle. Journal of Cachexia, Sarcopenia and Muscle, 10.1002/jcsm.12844, in press.
  • Sartori, A. Hagg, S. Zampieri, A. Armani, C.E. Winbanks, L.R. Viana, M. Haidar , K.I. Watt, H. Qian, C. Pezzini, P. Zanganeh, B.J. Turner, A. Larsson, G. Zanchettin, E.S. Pierobon, L. Moletta, M. Valmasoni, A. Ponzoni, S. Attar, G. DaDalt, C. Sperti, M. Kustermann, R.E. Thomson, L. Larsson, K.L. Loveland, P. Costelli, A. Megighian, S. Merigliano, F. Penna, P. Gregorevic, M.Sandri (2021). Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia. Science Translational Medicine, 4;13(605):eaay9592.
  • Costamagna, R. Duelen, F. Penna, D. Neumann, P. Costelli, M. Sampaolesi (2020). Interleukin 4 administration improves muscle function, adult myogenesis and lifespan of colon carcinoma-bearing mice. Journal of Cachexia, Sarcopenia and Muscle, 11: 783-801.
  • Penna, R. Ballarò, P. Martinez-Cristobal, D. Sala, D. Sebastian, S. Busquets, M. Muscaritoli, JM Argilés, P. Costelli, A. Zorzano (2019). Autophagy exacerbates muscle wasting in cancer cachexia and impairs mitochondrial function. J. Mol. Biol., 431: 2674-2686.
  • Ballarò, M. Beltrà, S. De Lucia, F. Pin, K. Ranjbar, J.J. Hulmi, P. Costelli, F. Penna (2019). Moderate exercise in mice improves cancer plus chemotherapy-induced muscle wasting and mitochondrial alterations. FASEB J., 33: 5482-5494.

Embodied Minds

Ostacoli, L., Cosma, S., Bevilacqua, F. et al.
Psychosocial factors associated with postpartum psychological distress during the Covid-19 pandemic: a cross-sectional study. BMC Pregnancy Childbirth 20, 703 (2020)
https://doi.org/10.1186/s12884-020-03399-5

Carletto, S., Porcaro, C., Settanta, C., Vizzari, V., Stanizzo, M. R., Oliva, F., Torta, R., Fernandez, I., Coletti Moja, M., Pagani, M., & Ostacoli, L. (2019).
Neurobiological features and response to eye movement desensitization and reprocessing treatment of posttraumatic stress disorder in patients with breast cancer. European journal of psychotraumatology, 10(1), 1600832.
https://doi.org/10.1080/20008198.2019.1600832

Ostacoli, L., Carletto, S., Cavallo, M., Baldomir-Gago, P., Di Lorenzo, G., Fernandez, I., Hase, M., Justo-Alonso, A., Lehnung, M., Migliaretti, G., Oliva, F., Pagani, M., Recarey-Eiris, S., Torta, R., Tumani, V., Gonzalez-Vazquez, A. I., & Hofmann, A. (2018).
Comparison of Eye Movement Desensitization Reprocessing and Cognitive Behavioral Therapy as Adjunctive Treatments for Recurrent Depression: The European Depression EMDR Network (EDEN) Randomized Controlled Trial. Frontiers in psychology, 9, 74.
https://doi.org/10.3389/fpsyg.2018.00074

Carletto, S., Tesio, V., Borghi, M., Francone, D., Scavelli, F., Bertino, G., Malucchi, S., Bertolotto, A., Oliva, F., Torta, R., & Ostacoli, L. (2017).
The Effectiveness of a Body-Affective Mindfulness Intervention for Multiple Sclerosis Patients with Depressive Symptoms: A Randomized Controlled Clinical Trial. Frontiers in psychology, 8, 2083.
https://doi.org/10.3389/fpsyg.2017.02083

Carletto, S., Borghi, M., Bertino, G., Oliva, F., Cavallo, M., Hofmann, A., Zennaro, A., Malucchi, S., & Ostacoli, L. (2016).
Treating Post-traumatic Stress Disorder in Patients with Multiple Sclerosis: A Randomized Controlled Trial Comparing the Efficacy of Eye Movement Desensitization and Reprocessing and Relaxation Therapy. Frontiers in psychology, 7, 526
https://doi.org/10.3389/fpsyg.2016.00526

Endocrinology

Giordano. Should all patients with adrenal insufficiency or a subgroup of patients with prediabetes be treated with dual-release hydrocortisone? Clin Endocrinol. 2018;89:297-298.

Parasiliti-Caprino, B. Lucatello, C. Lopez, J. Burrello, F. Maletta, M. Mistrangelo, E. Migliore, F. Tassone, A La Grotta, A. Pia, G. Reimondo, R. Giordano, G. Giraudo, A. Piovesan, G. Ciccone, D. Deandreis, P. Limone, F. Orlandi, G. Borretta, M. Volante, P. Mulatero, M. Papotti, G. Aimaretti, M. Terzolo, M. Morino, B. Pasini, F. Veglio, E. Ghigo, E. Arvat and M. Maccario. PREDICTORS OF RECURRENCE OF PHEOCHROMOCYTOMA AND PARAGANGLIOMA: A MULTICENTER STUDY IN PIEDMONT, ITALY. Hypertens Res. 2020 Jun;43(6):500-510.

M. Berton, N. Prencipe, R. Giordano, E. Ghigo, S. Grottoli. SYSTEMIC STEROIDS IN PATIENTS WITH COVID-19: PROS AND CONTRAS, AN ENDOCRINOLOGICAL POINT OF VIEW. J Endocrinol Invest. 2020 Jun; 8: 1–3.

Ponzetto, F. Settanni, M. Parasiliti‑Caprino, F. Rumbolo1o, A. Nonnato, M. Ricciardo, E. Amante, G. Priolo, S. Vitali, L. Anfossi, E. Arvat, E. Ghigo, R. Giordano, G. Mengozzi. Reference ranges of late-night salivary cortisol and cortisone measured by LC-MS/MS and accuracy for the diagnosis of Cushing’ syndrome. J Endocrinol Invest 2020; 43 (12): 1797-1806.

Parasiliti-Caprino, F. Bioletto, T. Frigerio, V. D'Angelo, F. Ceccato, F. Ferraù, R. Ferrigno, M. Minnetti, C. Scaroni, S. Cannavò, R. Pivonello, A. M. Isidori, F. Broglio, R. Giordano, M. Spinello, S. Grottoli and E. Arvat. A NEW CLINICAL MODEL TO ESTIMATE THE PRE-TEST PROBABILITY OF CUSHING’S SYNDROME: THE CUSHING SCORE. Front Endocrinol (Lausanne). 2021;12:747549.

Epidemiologia

Tarekegn A, Ricceri F, Costa G, Ferracin E, Giacobini M. Predictive Modeling for Frailty Conditions in Elderly People: Machine Learning Approaches. JMIR Med Inform. 2020 Jun 4;8(6):e16678

Freisling H, Viallon V, Lennon H, Bagnardi V, Ricci C, Butterworth AS, Sweeting M, Muller D, Romieu I, Bazelle P, Kvaskoff M, Arveux P, Severi G, Bamia C, Kühn T, Kaaks R, Bergmann M, Boeing H, Tjønneland A, Olsen A, Overvad K, Dahm CC, Menéndez V, Agudo A, Sánchez MJ, Amiano P, Santiuste C, Gurrea AB, Tong TYN, Schmidt JA, Tzoulaki I, Tsilidis KK, Ward H, Palli D, Agnoli C, Tumino R, Ricceri F, Panico S, Picavet HSJ, Bakker M, Monninkhof E, Nilsson P, Manjer J, Rolandsson O, Thysell E, Weiderpass E, Jenab M, Riboli E, Vineis P, Danesh J, Wareham NJ, Gunter MJ, Ferrari P. Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study. BMC Med. 2020 Jan 10;18(1):5

Sacerdote C, Ricceri F. Epidemiological dimensions of the association between type 2 diabetes and cancer: a review of observational studies. Diabetes Res Clin Pract. 2018;143:369-377

Ricceri F, Fasanelli F, Giraudo MT, Sieri S, Tumino R, Mattiello A, Vagliano L, Masala G, Quirós JR, Travier N, Sánchez MJ, Larranaga N, Chirlaque MD, Ardanaz E, Tjonneland A, Olsen A, Overvad K, Chang-Claude J, Kaaks R, Boeing H, Clavel-Chapelon F, Kvaskoff M, Dossus L, Trichopoulou A, Benetou V, Adarakis G, Bueno-de-Mesquita HB, Peeters PH, Sund M, Andersson A, Borgquist S, Butt S, Weiderpass E, Skeie G, Khaw KT, Travis RC, Rinaldi S, Romieu I, Gunter M, Kadi M, Riboli E, Vineis P, Sacerdote C. Risk of second primary malignancies in women with breast cancer: results from the European Prospective Investigation into Cancer and Nutrition (EPIC). Int J Cancer. Aug 15;137(4):940-948

Bronsino M, Castagneri C, Spinazzola M, Pepe RR, Sacerdote C, Ricceri F. "Journey of hope": a study on sexual gender-based violence reported by asylum-seeking women during their journey to Europe. Epidemiol Prev. 2020 Sep-Dec;44(5-6 Suppl 1):102-106

Ferrante G, Fasanelli F, Gigantesco A, Ferracin E, Contoli B, Costa G, Gargiulo L, Marra M, Masocco M, Minardi V, Violani C, Zengarini N, d'Errico A, Ricceri F. Is the association between precarious employment and mental health mediated by economic difficulties in males? Results from two Italian studies. BMC Public Health. 2019 Jul 3;19(1):869

Stringhini S, Carmeli C, Jokela M, Avendaño M, Muennig P, Guida F, Ricceri F, d’Errico A, Barros H, Bochud M, Chadeau-Hyam M, Clavel-Chapelon F, Costa G, Delpierre C, Fraga S, Goldberg M, Giles G, Krogh V, Kelly Irving M, Layte R, Lasserre AM, Marmot MG, Preisig M, Shipley MJ, Vollenweider P, Zins M, Kawachi I, Steptoe A, Mackenbach JP, Vineis P, Kivimäki M, the LIFEPATH consortium. Socioeconomic status and the 25 × 25 risk factors as determinants of premature mortality: a multicohort study and meta-analysis of 1 × 7 million men and women. 2017 Jan 31. pii: S0140-6736(16)32380-7

Ricceri F, Sacerdote C, Giraudo MT, Fasanelli F, Lenzo G, Galli M, Sieri S, Pala V, Masala G, Bendinelli B, Tumino R, Frasca G, Chiodini P, Mattiello A, Panico R. The association between Socioeconomic Status and Cardiovascular and Cerebrovascular Diseases within the EPICOR study: new evidence for an old inequality problem. PLoS One. Oct 6;11(10):e0164130

Sacerdote C, Ricceri F, Rolandsson O, Baldi I, Chirlaque MD, Feskens E, Bendinelli B, Ardanaz E, Arriola L, Balkau B, Bergmann M, Beulens JWJ, Boeing H, Clavel-Chapelon F, Crowe F, de Lauzon-Guillain B, Forouhi N, Franks P, Gallo V, Gonzalez C, Halkjær J, Illner AK, Kaaks R, Key T, Khaw KT, Navarro C, Nilsson PM, Oksbjerg Dal ton S, Overvad K, Pala V, Palli D, Panico S, Polidoro S, Quirós JR, Romieu I, Sánchez MJ, Slimani N, Sluijs I, Spijkerman A, Teucher B, Tjønneland A, Tumino R, van der A D, Vergnaud AC, Wennberg P, Sharp S, Langenberg C, Riboli E, Vineis P, Wareham N. Lower educational level is a predictor of incident type 2 diabetes in European Countries. The EPIC-InterAct Study. Int J Epidemiology. 2012 Aug; 41(4):1162-73

Caramello V, Macciotta A, Bar F, Mussa A, De Leo AM, De Salve AV, Nota F, Sacerdote C, Ricceri F, Boccuzzi A. The broad spectrum of COVID-like patients initially negative at RT-PCR testing: a cohort study. BMC Public Health. 2022 Jan 7;22(1):45

Caramello V, Boccuzzi A, Basile V, Ferraro A, Macciotta A, Catalano A, Costa G, Vineis P, Sacerdote C, Ricceri F. Are antigenic tests useful for detecting SARS-CoV-2 infections in patients accessing to emergency departments? Results from a North-West Italy Hospital. J Infect. 2021 May 20:S0163-4453(21)00255-3

Fornili M, Petri D, Berrocal C, Fiorentino G, Ricceri F, Macciotta A, Bruno A, Farinella D, Baccini M, Severi G, Baglietto L. Psychological distress in the academic population and its association with socio-demographic and lifestyle characteristics during COVID-19 pandemic lockdown: Results from a large multicenter Italian study. PLoS One. 2021 Mar 10;16(3):e0248370

Caramello V, Maciotta A, De Salve AV, Gobbi V, Ruffino TM, Mazzetti G, Ricagni L, Ling C, Arione R, Boccuzzi A, Costa G, Sacerdote C, Ricceri F. Clinical characteristics and management of COVID-19 patients accessing the emergency department in a hospital in Northern Italy in March and April 2020. Epidemiol Prev. 2020 Sep-Dec;44(5-6 Suppl 2):208-215

Gnavi R, Demaria M, Picariello R, Dalmasso M, Ricceri F, Costa G. Therapy with agents acting on the renin-angiotensin system and risk of SARS-CoV-2 infection. Clin Infect Dis. 2020;71(16):2291-2293

Genomic Regulation Group

Elhasnaoui J, Ferrero G, Miano V, Cutrupi S, De Bortoli M. The Estrogen Receptor α Signaling Pathway Controls Alternative Splicing in the Absence of Ligands in Breast Cancer Cells. Cancers. 2021 Jan;13(24):6261. doi: 10.3390/cancers13246261

Giordano G, Merlini A, Ferrero G, Mesiano G, Fiorino E, Brusco S, Centomo ML, Leuci V, D'Ambrosio L, Aglietta M, Sangiolo D, Grignani G, Pignochino Y. EphA2 Expression in Bone Sarcomas: Bioinformatic Analyses and Preclinical Characterization in Patient-Derived Models of Osteosarcoma, Ewing's Sarcoma and Chondrosarcoma. Cells. 2021 Oct 26;10(11):2893. doi: 10.3390/cells10112893.

Ferrero G, Licheri N, Coscujuela Tarrero L, De Intinis C, Miano V, Calogero RA, Cordero F, De Bortoli M, Beccuti M. Docker4Circ: a framework for the reproducible characterization of circRNAs from RNA-Seq data. International journal of molecular sciences. 2020 Jan;21(1):293.

Guglielmotto M, Reineri S, Iannello A, Ferrero G, Vanzan L, Miano V, Ricci L, Tamagno E, De Bortoli M, Cutrupi S.E2 Regulates Epigenetic Signature on Neuroglobin Enhancer-Promoter in Neuronal Cells. Front Cell Neurosci. 2016 Jun 1;10:147

Caizzi L, Ferrero G, Cutrupi S, Cordero F, Ballaré C, Miano V, Reineri S, Ricci L, Friard O, Testori A, Corà D, Caselle M, Di Croce L, De Bortoli M.Genome-wide activity of unliganded estrogen receptor-α in breast cancer cells. Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4892-7.

Hepatic Pathophysiology and Hepatocellular Carcinoma

Morello E, Sutti S, Foglia B, Novo E, Cannito S, Bocca C, Rajsky M, Bruzzì S, Abate ML, Rosso C, Bozzola C, David E, Bugianesi E, Albano E, Parola M.
Hypoxia-inducible factor 2α drives nonalcoholic fatty liver progression by triggering hepatocyte release of histidine-rich glycoprotein.
Hepatology. 2018 Jun; 67(6):2196-2214
https://doi.org/10.1002/hep.29754

Parola M, Pinzani M.
Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues.
Mol Aspects Med. 2019 Feb; 65:37-55.
https://doi.org/10.1016/j.mam.2018.09.002

Cannito S, Foglia B, Villano G, Turato C, Delgado TC, Morello E, Pin F, Novo E, Napione L, Quarta S, Ruvoletto M, Fasolato S, Zanus G, Colombatto S, Lopitz-Otsoa F, Fernández-Ramos D, Bussolino F, Sutti S, Albano E, Martínez-Chantar ML, Pontisso P, Parola M.
SerpinB3 Differently Up-Regulates Hypoxia Inducible Factors -1α and -2α in Hepatocellular Carcinoma: Mechanisms Revealing Novel Potential Therapeutic Targets.
Cancers (Basel). 2019 Dec 4;11(12):1933.
https://doi.org/10.3390/cancers11121933

Foglia B, Sutti S, Cannito S, Rosso C, Maggiora M, Autelli R, Novo E, Bocca C, Villano G, Ramavath NN, Younes R, Tusa I, Rovida E, Pontisso P, Bugianesi E, Albano E, Parola M.
Hepatocyte-Specific Deletion of HIF2α Prevents NASH-Related Liver Carcinogenesis by Decreasing Cancer Cell Proliferation.
Cell Mol Gastroenterol Hepatol. 2022;13(2):459-482.
https://doi.org/10.1016/j.jcmgh.2021.10.002

Di Maira G, Foglia B, Napione L, Turato C, Maggiora M, Sutti S, Novo E, Alvaro M, Autelli R, Colombatto S, Bussolino F, Carucci P, Gaia S, Rosso C, Biasiolo A, Pontisso P, Bugianesi E, Albano E, Marra F, Parola M, Cannito S.
Oncostatin M is overexpressed in NASH-related hepatocellular carcinoma and promotes cancer cell invasiveness and angiogenesis.
J Pathol. 2022 Jan 22.
https://doi.org/10.1002/path.5871

Inflammation and oxidative stress in age-related diseases

Testa G, Staurenghi E, Giannelli S, Gargiulo S, Guglielmotto M, Tabaton M, Tamagno E, Gamba P, Leonarduzzi G. A silver lining for 24-hydroxycholesterol in Alzheimer's disease: The involvement of the neuroprotective enzyme sirtuin 1. Redox Biol. 2018 17:423-431. ISSN: 2213-2317.

Gamba P, Staurenghi E, Testa G, Giannelli S, Sottero B, Leonarduzzi G. A Crosstalk Between Brain Cholesterol Oxidation and Glucose Metabolism in Alzheimer's Disease. Front Neurosci. 2019 13:556. ISNN: 1662-453x

Testa G, Staurenghi E, Giannelli S, Sottero B, Gargiulo S, Poli G, Gamba P, Leonarduzzi G. Up-regulation of PCSK6 by lipid oxidation products: A possible role in atherosclerosis. Biochimie. 2021 181:191-203. ISNN: 0300-9084

Staurenghi E, Cerrato V, Gamba P, Testa G, Giannelli S, Leoni V, Caccia C, Buffo A, Noble W, Perez-Nievas BG, Leonarduzzi G. Oxysterols present in Alzheimer's disease brain induce synaptotoxicity by activating astrocytes: A major role for lipocalin-2. Redox Biol. 2021 39:101837. ISSN: 2213-2317.

Gamba P, Giannelli S, Staurenghi E, Testa G, Sottero B, Biasi F, Poli G, Leonarduzzi G. The Controversial Role of 24-S-Hydroxycholesterol in Alzheimer's Disease. Antioxidants (Basel). 2021 10(5):740. ISNN: 2076-3921

Innovative medicine and molecular genetics

Vitale E, Rossin D, Perveen S, Miletto I, Lo Iacono M, Rastaldo R, Giachino C. Silica Nanoparticle Internalization Improves Chemotactic Behaviour of Human Mesenchymal Stem Cells Acting on the SDF1α/CXCR4 Axis. Biomedicines 2022, 10(2), 336. doi.org/10.3390/biomedicines10020336

Lo Iacono M, Puglisi S, Perotti P, Saba L, Petiti J, Giachino C, Reimondo G, Terzolo M. Molecular Mechanisms of Mitotane Action in Adrenocortical Cancer Based on In Vitro Studies. Cancers (Basel). 2021 Oct 20;13(21):5255. doi: 10.3390/cancers13215255.

Lo Iacono M, Signorino E, Petiti J, Pradotto M, Calabrese C, Panuzzo C, Caciolli F, Pergolizzi B, De Gobbi M, Rege-Cambrin G, Fava C, Giachino C, Bracco E, Saglio G, Frassoni F, Cilloni D. Genetic Screening for Potential New Targets in Chronic Myeloid Leukemia Based on Drosophila Transgenic for Human BCR-ABL1. Cancers (Basel). 2021 Jan 14;13(2):293. doi: 10.3390/cancers13020293.

Bellotti E, Cascone MG, Barbani N, Rossin D, Rastaldo R, Giachino C, Cristallini C. Targeting Cancer Cells Overexpressing Folate Receptors with New Terpolymer-Based Nanocapsules: Toward a Novel Targeted DNA Delivery System for Cancer Therapy. Biomedicines. 2021 Sep 21;9(9):1275. doi: 10.3390/biomedicines9091275.

Cristallini C, Vaccari G, Barbani N, Cibrario Rocchietti E, Barberis R, Falzone M, Cabiale K, Perona G, Bellotti E, Rastaldo R, Pascale S, Pagliaro P, Giachino C. Cardioprotection of PLGA/gelatine cardiac patches functionalised with adenosine in a large animal model of ischaemia and reperfusion injury: A feasibility study. J Tissue Eng Regen Med. 2019 Jul;13(7):1253-1264. doi: 10.1002/term.2875.

Internal medicine

PUBLICATIONS

  1. Puglisi S, Calabrese A, Basile V, Ceccato F, Scaroni C, Altieri B, Della Casa S, Loli P, Pivonello R, De Martino MC, Canu L, Russo M, Badalamenti G, Torlontano M, Stigliano A, Ferraù F, Arnaldi G, Saba L, Quirino A, Perotti P, Berchialla P, Terzolo M., Mitotane Concentrations Influence Outcome in Patients with Advanced Adrenocortical Carcinoma,Cancers 2020; 12:740.
  2. Basile V, Puglisi S, Calabrese A, Pia A, Perotti P, Berruti A, Reimondo G, Terzolo M., Unwanted Hormonal and Metabolic Effects of Postoperative Adjuvant Mitotane Treatment for Adrenocortical Cancer, Cancers 2020; 12(9):2615.
  3. Reimondo G, Castellano E, Grosso M, Puglisi S, Pia A, Pellegrino M, Borretta G, Terzolo M., Adrenal incidentalomas are tied to increased risk of diabetes: findings from a prospective study, J Clin Endocrinol Metab 2020; 105: dgz284.
  4. Calabrese A, Basile V, Puglisi S, Perotti P, Pia A, Saba L, Berchialla P, Porpiglia F, Veltri A, Volante M, Reimondo G, Berruti A, Terzolo M., Adjuvant mitotane therapy is beneficial in non-metastatic adrenocortical carcinoma at high risk of recurrence, Eur J Endocrinol. 2019; 180:387-396.
  5. Terzolo M, Angeli A, Fassnacht M, Daffara F, Tauchmanova L, Conton PA, Rossetto R, Buci L, Sperone P, Grossrubatscher E, Reimondo G, Bollito E, Papotti M, Saeger W, Hahner S,  Koschker AC, Arvat E, Ambrosi B, Loli P, Lombardi G, Mannelli M, Bruzzi P, Mantero F, Allolio  B, Dogliotti L, Berruti A., Adjuvant mitotane treatment for adrenocortical carcinoma, N Engl J Med. 2007; 356:2372-80.

Iron Metabolism

Iron Overload, Oxidative Stress, and Ferroptosis in the Failing Heart and Liver.
Mancardi D, Mezzanotte M, Arrigo E, Barinotti A, Roetto A.
Antioxidants (Basel). 2021 Nov 24;10(12):1864. doi: 10.3390/antiox10121864.

The Functional Versatility of Transferrin Receptor 2 and Its Therapeutic Value.
Roetto A, Mezzanotte M, Pellegrino RM.
Pharmaceuticals (Basel). 2018 Oct 23;11(4):115. doi: 10.3390/ph11040115.

TFR2-Related Hereditary Hemochromatosis.
De Gobbi M, Roetto A.
2005 Aug 29 [updated 2018 Feb 15]. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Mirzaa GM, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2022.
PMID: 20301523

Transferrin Receptor 2 Dependent Alterations of Brain Iron Metabolism Affect Anxiety Circuits in the Mouse.
Pellegrino RM, Boda E, Montarolo F, Boero M, Mezzanotte M, Saglio G, Buffo A, Roetto A.
Sci Rep. 2016 Aug 1;6:30725. doi: 10.1038/srep30725.

Comparison of 3 Tfr2-deficient murine models suggests distinct functions for Tfr2-alpha and Tfr2-beta isoforms in different tissues.
Roetto A, Di Cunto F, Pellegrino RM, Hirsch E, Azzolino O, Bondi A, Defilippi I, Carturan S, Miniscalco B, Riondato F, Cilloni D, Silengo L, Altruda F, Camaschella C, Saglio G.
Blood. 2010 Apr 22;115(16):3382-9. doi: 10.1182/blood-2009-09-240960. Epub 2010 Feb 23.
PMID: 20179178

Laboratory of Cell Biology

Ali MS, Panuzzo C, Calabrese C, Maglione A, Piazza R, Cilloni D, Saglio G, Pergolizzi B, Bracco E. The Giant HECT E3 Ubiquitin Ligase HERC1 Is Aberrantly Expressed in Myeloid Related Disorders and It Is a Novel BCR-ABL1 Binding Partner. Cancers (Basel). 2021 Jan 19;13(2):341. doi: 10.3390/cancers13020341. PMID: 33477751; PMCID: PMC7832311.

Ali MS, Magnati S, Panuzzo C, Cilloni D, Saglio G, Pergolizzi B, Bracco E. The Downregulation of Both Giant HERCs, <i>HERC1</i> and <i>HERC2</i>, Is an Unambiguous Feature of Chronic Myeloid Leukemia, and HERC1 Levels Are Associated with Leukemic Cell Differentiation. J Clin Med. 2022 Jan 10;11(2):324. doi: 10.3390/jcm11020324. PMID: 35054018; PMCID: PMC8778248.

Pergolizzi B, Bozzaro S, Bracco E. Dictyostelium as model for studying ubiquitination and deubiquitination. Int J Dev Biol. 2019;63(8-9-10):529-539. doi: 10.1387/ijdb.190260eb. PMID: 31840790.

Pergolizzi B, Bracco E, Bozzaro S. A new HECT ubiquitin ligase regulating chemotaxis and development in Dictyostelium discoideum. J Cell Sci. 2017 Feb 1;130(3):551-562. doi: 10.1242/jcs.194225. Epub 2017 Jan 3. PMID: 28049717.

Pergolizzi B, Bozzaro S, Bracco E. G-Protein Dependent Signal Transduction and Ubiquitination in Dictyostelium. Int J Mol Sci. 2017 Oct 19;18(10):2180. doi: 10.3390/ijms18102180. PMID: 29048338; PMCID: PMC5666861.

Laboratory of Neuroimmunology

PUBLICATIONS/PUBBLICAZIONI

  • Rolla, S; Ferrocino, I; Bardina, V; Ferraro, M; Cianflone, A; Lanzillo, R; De Mercanti, S; Cocolin, L; Clerico, M. “Gut microbiota and metagenomic diversity in Clinical Isolated Syndrome” In NEUROLOGY - ISSN:0028-3878 vol. 90 (Supplement 15, P2.357);
  • Rolla, S; Bardina, V; Ferrocino, I; De Mercanti, S; Via, AG; Lamberti, A; Lanzillo, R; Bonavita, S; Esposito, S; Giordano, M; Cocolin, LS; Clerico, M. “Alterations in gut microbiome are associated with the onset of multiple sclerosis: an Italian pivotal study” In MULTIPLE SCLEROSIS - ISSN:1352-4585 vol. 24:399;
  • Maglione A, Zuccalà M, Tosi M, Clerico M, Rolla S. “Host Genetics and Gut Microbiome: Perspectives for Multiple Sclerosis” Genes, 2021;12(8):1181

  • Sormani, M.P.; Schiavetti, I.; Carmisciano, L.; Sormani, M.P.; Inglese, M.; Laroni, A.; Lapucci, C.; Uccelli, A.; Inglese, M.; Lapucci, C.; et al. Effect of SARS-CoV-2 MRNA Vaccination in MS Patients Treated with Disease Modifying Therapies. eBioMedicine 2021, 72, doi:10.1016/j.ebiom.2021.103581.
  • Clerico, M.; Maglione, A.; Morra, M.; Francese, R.; Civra, A.; Lembo D. & Rolla S. Anti-SARS-Cov-2 neutralizing antibodies in subjects with multiple sclerosis: an Italian monocentric study. Conference abstract for 2022 AAN Annual Meeting. Seattle, 2022 April 2–7.

  • Di Tella, M.; Perutelli, V.; Miele, G.; Lavorgna, L.; Bonavita, S.; De Mercanti, S. F.; Streito, L. M.; Clerico, M.; Castelli, L. (2021). “Family functioning and Multiple Sclerosis: Study Protocol of a Multicentric Italian project”. Frontiers in Psychology.
  • Lavorgna, L.; Di Tella, M; Miele, G.; De Mercanti, S. F.; Streito, L. M.; Perutelli, V.; Bonavita, S.; Castelli, L. and Clerico, M. (2020). “Online Validation of a Battery of Questionnaires for the Assessment of Family Functioning and Related Factors”. Frontiers in Psychology.

Mechanisms of autophagy-mediated anticancer drug resistance of breast and liver cancer cells

Autelli, R.; Costelli, P.; Crepaldi, T.; Penna, F.; Tamagno, E. (2016)
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
https://iris.unito.it/handle/2318/1550759

Ullio, Chiara, Brunk, Ulf T , Urani, Chiara, Melchioretto, Pasquale, Bonelli, Gabriella, Baccino, Francesco M , Autelli, Riccardo (2015)
AUTOPHAGY OF METALLOTHIONEINS PREVENTS TNF-INDUCED OXIDATIVE STRESS AND TOXICITY IN HEPATOMA CELLS.
https://iris.unito.it/handle/2318/1550662

Cannito S, Turato C, Paternostro C, Biasiolo A, Colombatto S, Cambieri I, Quarta S, Novo E, Morello E, Villano G, Cillo U, Fasolato S, Musso T, David E, Tusa I, Rovida E, Autelli R, Smedile A, Cillo U, Pontisso P, Parola M (2015)
Hypoxia up-regulates SERPINB3 through HIF-2? in human liver cancer cells.
https://iris.unito.it/handle/2318/154507

C BOCCA, M IEVOLELLA, R AUTELLI, M MOTTA, L MOSSO, B TORCHIO, F BOZZO, S CANNITO, C PATERNOSTRO, S COLOMBATTO, M PAROLA, A MIGLIETTA (2014)
EXPRESSION OF COX-2 IN HUMAN BREAST CANCER CELLS AS A CRITICAL DETERMINANT OF EPITHELIAL-MESENCHYMAL TRANSITION AND INVASIVENESS.
https://iris.unito.it/handle/2318/139953

C Ullio, J Casas, U T Brunk, G Sala, G Fabriàs, R Ghidoni, G Bonelli, F M Baccino, R Autelli (2013)
LYSOSOMAL MECHANISMS OF DEATH BY TNF IN HEPATOMA CELLS.
https://iris.unito.it/handle/2318/152996

Autelli R, Ullio C, Prigione E, Crepaldi S, Schiavone N, Brunk UT, Capaccioli S, Baccino FM, Bonelli G (2009)
Divergent pathways for TNF and C(2)-ceramide toxicity in HTC hepatoma cells.
https://iris.unito.it/handle/2318/57488

Neuromuscular function

Lupo C., Ungureanu A.N., Boccia G., Licciardi A., Rainoldi A., Brustio P.R. (2021). Internal training load monitoring, notational and time motion analyses, psychometric status, and neuromuscular responses in elite rugby union. International Journal of Sports Physiology and Performance. 16, 421–428. https://doi.org/10.1123/ijspp.2020-0260. ISSN: 1555-0265.

Boccia G, Dardanello D, Brustio PR, Tarperi C, Festa L, Zoppirolli C, Pellegrini B, Schena F, Rainoldi A (2018) Neuromuscular fatigue does not impair the rate of force development in ballistic contractions of submaximal amplitudes, Front. Physiol. 9: 1503. doi: 10.3389/fphys.2018.01503

Brustio, P.R., Moise, P., Marasso, D., Miglio, F., Rainoldi, A., & Boccia, G. (2018) Feasibility of implementing an outdoor walking break in Italian middle schools. PLoS ONE 13(8): e0202091. doi: 10.1371/journal.pone.0202091.

Mulasso, A., Brustio, P.R., Rainoldi, A., Zia G., Feletti, L., N’dja, A., Del Signore, S, Poggiogalle E., Luisi F., Donini, L.M. (2019) A comparison between an ICT tool and a traditional physical measure for frailty evaluation in older adults. BMC Geriatrics, 19:88 doi: 10.1186/s12877-019-1089-z

Brustio, P.R., Lupo, C., Ungureano A.N., Frati, R., Rainoldi, A., & Boccia, G. (2018) The relative age effect is larger in Italian soccer top-level youth categories and smaller in Serie A. PLOS ONE, 13(4): e0196253. doi:10.1371/journal.pone.0196253.

Obstructive Pulmonary Disease Group

Kim RY, Sunkara KP, Bracke KR, Jarnicki AG, Donovan C, Hsu AC, Ieni A, Beckett EL, Galvão I, Wijnant S, Ricciardolo FL, Di Stefano A, Haw TJ, Liu G, Ferguson AL, Palendira U, Wark PA, Conickx G, Mestdagh P, Brusselle GG, Caramori G, Foster PS, Horvat JC, Hansbro PM. A microRNA-21-mediated SATB1/S100A9/NF-κB axis promotes chronic obstructive pulmonary disease pathogenesis. Sci Transl Med. 2021 Nov 24;13(621):eaav7223. doi: 10.1126/scitranslmed.aav7223.

Ricciardolo FLM, Sprio AE, Baroso A, Gallo F, Riccardi E, Bertolini F, Carriero V, Arrigo E, Ciprandi G. Characterization of T2-Low and T2-High Asthma Phenotypes in Real-Life. Biomedicines. 2021 Nov 13;9(11):1684. doi: 10.3390/biomedicines9111684.

Bertolini F, Carriero V, Bullone M, Sprio AE, Defilippi I, Sorbello V, Gani F, Di Stefano A, Ricciardolo FLM. Correlation of matrix-related airway remodeling and bradykinin B1 receptor expression with fixed airflow obstruction in severe asthma. Allergy. 2021 Jun;76(6):1886-1890. doi: 10.1111/all.14691

Carriero V, Bertolini F, Sprio AE, Bullone M, Ciprandi G, Ricciardolo FLM. High levels of plasma fibrinogen could predict frequent asthma exacerbations. J Allergy Clin Immunol Pract. Jul-Aug 2020;8(7):2392-2395.e7. doi: 10.1016/j.jaip.2020.02.034.

Bullone M, Carriero V, Bertolini F, Folino A, Mannelli A, Di Stefano A, Gnemmi I, Torchio R, Ricciardolo FLM. Elevated serum IgE, oral corticosteroid dependence and IL-17/22 expression in highly neutrophilic asthma. Eur Respir J. 2019 Nov 7;54(5):1900068. doi: 10.1183/13993003.00068-2019.

Oxidative stress and chemoresistance

Ambrosio L, Argenziano M, Cucci MA, Grattarola M, de Graaf IAM, Dianzani C, Barrera G, Sánchez Nieves J, Gomez R, Cavalli R, Pizzimenti S. Carbosilane Dendrimers Loaded with siRNA Targeting Nrf2 as a Tool to Overcome Cisplatin Chemoresistance in Bladder Cancer Cells. Antioxidants (Basel). 2020, 9, 993.

Barrera G, Cucci MA, Grattarola M, Dianzani C, Muzio G, Pizzimenti S. Control of Oxidative Stress in Cancer Chemoresistance: Spotlight on Nrf2 Role. Antioxidants (Basel). 2021, 10, 510.

Grattarola M, Cucci MA, Roetto A, Dianzani C, Barrera G, Pizzimenti S. Post-translational down-regulation of Nrf2 and YAP proteins, by targeting deubiquitinases, reduces growth and chemoresistance in pancreatic cancer cells. Free Radic Biol Med. 2021,  174, 202.

Pizzimenti S, Ribero S, Cucci MA, Grattarola M, Monge C, Dianzani C, Barrera G, Muzio G. Oxidative Stress-Related Mechanisms in Melanoma and in the Acquired Resistance to Targeted Therapies. Antioxidants (Basel). 2021, 10, 1942.

Argenziano M, Bessone F, Dianzani C, Cucci MA, Grattarola M, Pizzimenti S*, Cavalli R* Ultrasound-Responsive Nrf2-Targeting siRNA-Loaded Nanobubbles for Enhancing the Treatment of Melanoma. Pharmaceutics 2022, 14, 341. * co-last authors

Pathophysiology of inflammatory intestinal diseases

Rossin D, Barbosa-Pereira L, Iaia N, Sottero B, Danzero AC, Poli G, Zeppa G, Biasi F. Protective Effect of Cocoa Bean Shell against Intestinal Damage: An Example of Byproduct Valorization. Antioxidants (Basel). 2021 Feb 12;10(2):280. doi: 10.3390/antiox10020280. PMID: 33673085; PMCID: PMC7918452.

Rossin D, Barbosa-Pereira L, Iaia N, Testa G, Sottero B, Poli G, Zeppa G, Biasi F. A Dietary Mixture of Oxysterols Induces In Vitro Intestinal Inflammation through TLR2/4 Activation: The Protective Effect of Cocoa Bean Shells. Antioxidants (Basel). 2019 May 31;8(6):151. doi: 10.3390/antiox8060151. PMID: 31151323; PMCID: PMC6617147.

Rossin D, Dias IHK, Solej M, Milic I, Pitt AR, Iaia N, Scoppapietra L, Devitt A, Nano M, Degiuli M, Volante M, Caccia C, Leoni V, Griffiths HR, Spickett CM, Poli G, Biasi F. Increased production of 27-hydroxycholesterol in human colorectal cancer advanced stage: Possible contribution to cancer cell survival and infiltration. Free Radic Biol Med. 2019 May 20;136:35-44. doi: 10.1016/j.freeradbiomed.2019.03.020. Epub 2019 Mar 23. PMID: 30910555.

Serra G, Incani A, Serreli G, Porru L, Melis MP, Tuberoso CIG, Rossin D, Biasi F, Deiana M. Olive oil polyphenols reduce oxysterols -induced redox imbalance and pro-inflammatory response in intestinal cells. Redox Biol. 2018 Jul;17:348-354. doi: 10.1016/j.redox.2018.05.006. Epub 2018 May 16. PMID: 29793168; PMCID: PMC6007813.

Sottero B, Rossin D, Poli G, Biasi F. Lipid Oxidation Products in the Pathogenesis of Inflammation-related Gut Diseases. Curr Med Chem. 2018;25(11):1311-1326. doi: 10.2174/0929867324666170619104105. PMID: 28625152

Peripheral nerve regeneration group

El Soury M, Fornasari BE, Carta G, Zen F, Haastert-Talini K, Ronchi G. The Role of Dietary Nutrients in Peripheral Nerve Regeneration. Int J Mol Sci. 2021, 10; 22:7417.

Fornasari BE, Carta G, Gambarotta G, Raimondo S. Natural-Based Biomaterials for Peripheral Nerve Injury Repair. Front Bioeng Biotechnol. 2020, 16; 8:554257.

Fregnan F, Muratori L, Bassani GA, Crosio A, Biagiotti M, Vincoli V, Carta G, Pierimarchi P, Geuna S, Alessandrino A, Freddi G, Ronchi G. Preclinical Validation of SilkBridgeTM for Peripheral Nerve Regeneration. Front Bioeng Biotechnol. 2020, 7; 8:835.

Fornasari BE, El Soury M, Nato G, Fucini A, Carta G, Ronchi G, Crosio A, Perroteau I, Geuna S, Raimondo S, Gambarotta G. Fibroblasts Colonizing Nerve Conduits Express High Levels of Soluble Neuregulin1, a Factor Promoting Schwann Cell Dedifferentiation. Cells. 2020, 1; 9:1366.

Muratori L, Fregnan F, Ronchi G, Haastert-Talini K, Metzen J, Bertolo R, Porpiglia F, Geuna S. New basic insights on the potential of a chitosan-based medical device for improving functional recovery after radical prostatectomy. BJU Int. 2019, 124:1063-1076.

Polyunsaturated fatty acids in oncology and Tissue regeneration

PUBBLICAZIONI/PUBLICATIONS

  • Schierano G, Baldi D, Peirone B, Mauthe von Degerfeld M, Navone R, Bragoni A, Colombo J, Autelli R, Muzio G. Biomolecular, Histological, Clinical, and Radiological Analyses of Dental Implant Bone Sites Prepared Using Magnetic Mallet Technology: A Pilot Study in Animals. Materials (Basel). 2021 Nov 17;14(22):6945. doi: 10.3390/ma14226945.
  • Schierano G, Canuto RA, Mauthe von Degerfeld M, Navone R, Peirone B, Preti G, Muzio G. Role of rhBMP-7, Fibronectin, And Type I Collagen in Dental Implant Osseointegration Process: An Initial Pilot Study on Minipig Animals. Materials (Basel). 2021 Apr 24;14(9):2185. doi: 10.3390/ma14092185.

Psychiatry

Francesco Oliva, Giulia di Girolamo, Francesca Malandrone, Noemi Iaia, Fiorella Biasi & Giuseppe Maina. Early childhood infections, antistreptococcal and basal ganglia antibodies in adult ADHD: a preliminary study. BMC Psychiatry 20, 542 (2020). https://doi.org/10.1186/s12888-020-02946-w

Sanità pubblica

PUBBLICAZIONI/PUBLICATIONS

  • Piccoli Giorgina Barbara, Chatrenet Antoine, Cataldo Manuela, Torreggiani Massimo, Attini Rossella, Masturzo Bianca, Cabiddu Gianfranca, Versino Elisabetta. Adding creatinine to routine pregnancy tests: a decision tree for calculating the cost of identifying patients with CKD in pregnancy (Accepted) Neph Dyal Trans
  • Blanchi S, Torreggiani M, Chatrenet A, Fois A, Mazé B, Njandjo L, Bianco G, Lepori N, Pili A, Michel PA, Sileno G, Arazzi M, Esposito V, Pani A, Versino E, Esposito C, Fessi H, Cabiddu G, Piccoli GB. COVID-19 Vaccine Hesitancy in Patients on Dialysis in Italy and France. Kidney Int Rep. 2021 Nov;6(11):2763-2774. doi: 10.1016/j.ekir.2021.08.030. Epub 2021 Sep 8.
  • Covella B; Vinturache AE Cabiddu G; Attini R; Gesualdo L; Versino E; Piccoli GB. A systematic review and meta-analysis indicates long-term risk of chronic and end-stage kidney disease after preeclampsia. KIDNEY INTERNATIONAL 2019; 96 (3): 711-727
  • Gabrielli G, Paterno A e . Strozza S. Sexual behavioural differences and risk-taking differences among born-abroad and native university students in Italy”, Genus, 76:17, 2020, pp. 1-19. DOI: https://doi.org/10.1186/s41118-020-00088-1 . Open Access Journal
  • Versino E, Costa G Salmaso S. Registri e sorveglianze: lacune e prospettive. Epidemiologia&Prevenzione 2015, 39 (2) marzo-aprile

Cardiovascular Physiology Laboratory

PUBBLICAZIONI/PUBLICATIONS

  1. Zicola E, Arrigo E, Mancardi D. H2S Pretreatment Is Promigratory and Decreases Ischemia/Reperfusion Injury in Human Microvascular Endothelial Cells. Oxid Med Cell Longev. 2021 Apr 15;2021:8886666. doi: 10.1155/2021/8886666.
  2. Folino A, Accomasso L, Giachino C, Montarolo PG, Losano G, Pagliaro P, Rastaldo R. Apelin-induced cardioprotection against ischaemia/reperfusion injury: roles of epidermal growth factor and Src. Acta Physiol (Oxf). 2018 Feb;222(2). doi: 10.1111/apha.12924.
  3. Penna C, Femminò S, Caldera F, Rubin Pedrazzo A, Cecone C, Alfì E, Comità S, Higashiyama T, Trotta F, Pagliaro P, Cavalli R. Cyclic Nigerosyl-Nigerose as Oxygen Nanocarrier to Protect Cellular Models from Hypoxia/Reoxygenation Injury: Implications from an In Vitro Model. Int J Mol Sci. 2021 Apr 19;22(8):4208. doi: 10.3390/ijms22084208.
  4. Penna C, Sorge M, Tullio F, Comità S, Femminò S, Brancaccio M, Pagliaro P. A TRICk to Improve the Effectiveness of RIC: Role of Limb Temperature in Enhancing the Effectiveness of Remote Ischemic Conditioning. Biology (Basel). 2022 Jan 17;11(1):146. doi: 10.3390/biology11010146. PMID: 35053144; PMCID: PMC8773203.
  5. D'Ascenzo F, Femminò S, Ravera F, Angelini F, Caccioppo A, Franchin L, Grosso A, Comità S, Cavallari C, Penna C, De Ferrari GM, Camussi G, Pagliaro P, Brizzi MF. Extracellular vesicles from patients with Acute Coronary Syndrome impact on ischemia-reperfusion injury. Pharmacol Res. 2021 Aug;170:105715. doi: 10.1016/j.phrs.2021.105715.

Laboratory for Nutrition and Metabolic Disorders Research

Scientific Publications related to research

  1. Felicetti F, Aimaretti E, Dal Bello F, Gatti F, Godono A, Saba F, Einaudi G, Collino M, Fagioli F, Aragno M, Brignardello E. Advanced glycation end products and their related signaling cascades in adult survivors of childhood Hodgkin lymphoma: A possible role in the onset of late complications. Free Radic Biol Med. 2022 Jan;178:76-82. doi: 10.1016/j.freeradbiomed.2021.11.036. Epub 2021 Nov 30.
  2. Chimienti G, Orlando A, Russo F, D'Attoma B, Aragno M, Aimaretti E, Lezza AMS, Pesce V. The Mitochondrial Trigger in an Animal Model of Nonalcoholic Fatty Liver Disease Genes (Basel). 2021 Sep 18;12(9):1439.
  3. Mastrocola R, Dal Bello F, Cento AS, Gaens K, Collotta D, Aragno M, Medana C, Collino M, Wouters K, Schalkwijk CG. Altered hepatic sphingolipid metabolism in insulin resistant mice: Role of advanced glycation endproducts. Free Radic Biol Med. 2021 Jun;169:425-435. doi: 10.1016/j.freeradbiomed.2021.04.028.
  4. Mastrocola R, Collotta D, Gaudioso G, Le Berre M, Cento AS, Ferreira Alves G, Chiazza F, Verta R, Bertocchi I, Manig F, Hellwig M, Fava F, Cifani C, Aragno M, Henle T, Joshi L, Tuohy K, Collino M. Effects of Exogenous Dietary Advanced Glycation End Products on the Cross-Talk Mechanisms Linking Microbiota to Metabolic Inflammation. Nutrients. 2020 Aug 19;12(9):2497. doi: 10.3390/nu12092497.
  5. Aragno M, Mastrocola R. Dietary Sugars and Endogenous Formation of Advanced Glycation Endproducts: Emerging Mechanisms of Disease Nutrients. 2017,9(4). pii: E385.

Laboratory of Human Anatomy

Ronchi G, Cillino M, Gambarotta G, Fornasari BE, Raimondo S, Pugliese P, Tos P, Cordova A, Moschella F, Geuna S. Irreversible changes occurring in long-term denervated Schwann cells affect delayed nerve repair. J Neurosurg. 2017 Oct;127(4):843-856. 

Mazzara PG, Massimino L, Pellegatta M, Ronchi G, Ricca A, Iannielli A, Giannelli SG, Cursi M, Cancellieri C, Sessa A, Del Carro U, Quattrini A, Geuna S, Gritti A, Taveggia C, Broccoli V. Two factor-based reprogramming of rodent and human fibroblasts into Schwann cells. Nat Commun. 2017 Feb 7;8:14088. 

Fregnan F, Ciglieri E, Tos P, Crosio A, Ciardelli G, Ruini F, Tonda-Turo C, Geuna S, Raimondo S. Chitosan crosslinked flat scaffolds for peripheral nerve regeneration. Biomed Mater. 2016 Aug 10;11(4):045010. 

Meyer C, Stenberg L, Gonzalez-Perez F, Wrobel S, Ronchi G, Udina E, Suganuma S, Geuna S, Navarro X, Dahlin LB, Grothe C, Haastert-Talini K. Chitosan-film enhanced chitosan nerve guides for long-distance regeneration of peripheral nerves. Biomaterials. 2016 Jan;76:33-51. 

Moimas S, Novati F, Ronchi G, Zacchigna S, Fregnan F, Zentilin L, Papa G, Giacca M, Geuna S, Perroteau I, Arnež ZM, Raimondo S. Effect of vascular endothelial growth factor gene therapy on post-traumatic peripheral nerve regeneration and denervation-related muscle atrophy. Gene Ther. 2013 Oct;20(10):1014-21.

Laboratory of Molecular Virology and Antiviral Research

Research and development of antiviral molecules and materials/Ricerca e sviluppo di molecole e materiali antivirali

  • Sureram S, Arduino I, Ueoka R, Rittà M, Francese R, Srivibool R, Darshana D, Piel J, Ruchirawat S, Muratori L, Lembo D, Kittakoop P, Donalisio M. The Peptide A-3302-B Isolated from a Marine Bacterium Micromonospora sp. Inhibits HSV-2 Infection by Preventing the Viral Egress from Host Cells. Int J Mol Sci. 2022 Jan 15;23(2):947.
  • Donalisio M, Cirrincione S, Rittà M, Lamberti C, Civra A, Francese R, Tonetto P, Sottemano S, Manfredi M, Lorenzato A, Moro GE, Giribaldi M, Cavallarin L, Giuffrida MG, Bertino E, Coscia A, Lembo D. Extracellular Vesicles in Human Preterm Colostrum Inhibit Infection by Human Cytomegalovirus In Vitro. Microorganisms. 2020 Jul 21;8(7):1087.
  • Francese R, Civra A, Rittà M, Donalisio M, Argenziano M, Cavalli R, Mougharbel AS, Kortz U, Lembo D. Anti-zika virus activity of polyoxometalates. Antiviral Res. 2019 Mar;163:29-33.
  • Civra A, Francese R, Gamba P, Testa G, Cagno V, Poli G, Lembo D. 25-Hydroxycholesterol and 27-hydroxycholesterol inhibit human rotavirus infection by sequestering viral particles into late endosomes. Redox Biol. 2018 Oct;19:318-330.
  • Cagno V, Andreozzi P, D'Alicarnasso M, Jacob Silva P, Mueller M, Galloux M, Le Goffic R, Jones ST, Vallino M, Hodek J, Weber J, Sen S, Janeček ER, Bekdemir A, Sanavio B, Martinelli C, Donalisio M, Rameix Welti MA, Eleouet JF, Han Y, Kaiser L, Vukovic L, Tapparel C, Král P, Krol S, Lembo D, Stellacci F. Broad- spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism. Nature Materials. 2018 Feb;17(2):195-203.

Development of environmental virology techniques for the early detection and monitoring of respiratory viruses with pandemic potential/Sviluppo di tecniche di virologia ambientale per la rilevazione precoce e il monitoraggio di virus respiratori con potenziale pandemico

  • Buonanno G, Robotto A, Brizio E, Morawska L, Civra A, Corino F, Lembo D, Ficco G, Stabile L. Link between SARS-CoV-2 emissions and airborne concentrations: Closing the gap in understanding. J Hazard Mater. 2022 Apr 15;428:128279.
  • Robotto A, Lembo D, Quaglino P, Brizio E, Polato D, Civra A, Cusato J, Di Perri G. Wastewater-based SARS-CoV-2 environmental monitoring for Piedmont, Italy. Environ Res. 2022 Jan;203:111901.
  • Robotto A, Civra A, Quaglino P, Polato D, Brizio E, Lembo D. SARS-CoV-2 airborne transmission: A validated sampling and analytical method. Environ Res. 2021 Sep;200:111783.
  • Robotto A, Quaglino P, Lembo D, Morello M, Brizio E, Bardi L, Civra A. SARS-CoV-2 and indoor/outdoor air samples: a methodological approach to have consistent and comparable results. Environ Res. 2021 Apr;195:110847.

Prof. David Lembo and some members of the laboratory are scientific consultants for the following institutions/Il Prof. David Lembo ed alcuni componenti del laboratorio prestano servizio come consulenti scientifici presso i seguenti enti


logo arpa piemonte 

Arpa: Agenzia Regionale Protezione Ambiente

 

logo emba 

EMBA: European Milk Bank Association

 

aiblud logo 

AIBLUD: Associazione Italiana delle Banche del Latte Umano Donato

 

Il professor David Lembo è il Direttore di due Master universitari di II livello afferenti al Dipartimento di Scienze e Cliniche e Biologiche. Alcuni componenti del laboratorio sono coinvolti attivamente nel comitato scientifico e nell’insegnamento presso questi corsi. 

Professor David Lembo is the Director of two Master’s programmes of the Department of Clinical and Biological Sciences. Some components of the laboratory are actively involved in the scientific committee and in the teaching activities in these programmes. 


scuola in ospedale

Master di II Livello in La scuola in ospedale: la realtà professionale e le strategie didattiche di cura

 

master virologia ambientale

Master di II livello in Virologia Ambientale


Notizie ed approfondimenti sui Master:

 

Il laboratorio di Virologia Molecolare e Ricerca Antivirale è spesso coinvolto in attività di Public engagement quali la Notte Europea dei Ricercatori, le settimane della scienza a scuola ed alcune giornate divulgative su vari temi (vaccinazione, igiene delle mani).


 

Laboratory of Pharmacology

PUBLICATIONS/PUBBLICAZIONI

  • Silvia De Francia, Daniele Mancardi, Paola Berchialla, Tiziana Armando, Silvana Storto, Sarah Allegra, Giulia Soave, Silvia Racca, Francesco Chiara, Jennifer Carnovale, Libero Ciuffreda, Maria Valentina Mussa. “Gender-specific side effects of chemotherapy in pancreatic cancer patients”. Canadian Journal of Physiology and
    Pharmacology, 21 oct 2021. DOI: https://doi.org/10.1139/cjpp-2021-0622
  • Andrea Spini, Valentina Giudice, Vincenzo Brancaleone, Maria Grazia Morgese, Silvia De Francia, Amelia Filippelli, Anna Ruggieri, Marina Ziche, Elena Ortona, Andrea Cignarella, Luigia Trabace. “Sex-tailored pharmacology and COVID-19: next steps towards appropriateness and health equity”. DOI: https://doi.org/10.1016/j.phrs.2021.105848. Pharmacological Research, vol 173, nov 2021.
  • "Procedimento per determinare glifosato e acido aminometilfosfonico in un campione". Università degli Studi di Torino, Designated Inventors: Francesco CHIARA, Elisa ARRIGO, Sarah ALLEGRA, Silvia DE FRANCIA, Daniele MANCARDI. Domanda depositata il 27 maggio 2021 con il n. 102021000013796.
  • Andrea Piolatto, Paola Berchialla, Sarah Allegra, Silvia De Francia, Giovanni Battista Ferrero, Antonio Piga, Filomena Longo. “Pharmacological and clinical evaluation of deferasirox formulations for treatment tailoring”. Scientific Reports, Vol 11:12581, issue 1, doi 10.1038/s41598-021-91983-w.
  • Sarah Allegra, Soraya Puglisi, Irene Brescia, Francesco Chiara, Vittoria Basile, Anna Calabrese, Giuseppe Reimondo, Silvia De Francia. “Sex differences on mitotane concentration and treatment outcome in patients with adrenocortical carcinoma”. Life 2021, 11(3), 266; https://doi.org/10.3390/life11030266 - 23 mar 2021. Life | Special Issue : Gender-Specific Medicine and Pharmacology (mdpi.com)
  • Montarolo F, Martire S, Perga S, Spadaro M, Brescia I, Allegra S, De Francia S, Bertolotto A. “NURR1 deficiency is associated to ADHD-likephenotypes in mice”. Translational Psychiatry 2019 Aug 27;9(1):207. DOI: 10.1038/s41398-019-0544-0.

  • Racca S, Piccione F, Spaccamiglio A, Carriero VM, De Francia S, Cangemi L, Esculapio P, Papotti M, Migliaretti G, Portaleone P, Di Carlo F, Abbadessa G. Effects of subchronic nandrolone administration on hormonal adaptive response to acute stress in rats. Psychoneuroendocrinology. 2012 Aug;37(8):123447. doi:10.1016/j.psyneuen.2011.12.017. PMID: 22226432.
  • Pergolizzi B, Carriero V, Abbadessa G, Penna C, Berchialla P, De Francia S, Bracco E, Racca S. Subchronic nandrolone administration reduces cardiac oxidative markers during restraint stress by modulating protein expression patterns. Mol Cell Biochem. 2017 Apr 21. doi: 10.1007/s1101001730367.
  • Ivan Dimauro, Loredana Grasso, Simona Fittipaldi, Cristina Fantini, Neri Mercatelli, Silvia Racca, Stefano Geuna, Alessia Di Gianfrancesco, Daniela Caporossi, Fabio Pigozzi, Paolo Borrione, PlateletRich Plasma and Skeletal Muscle Healing: A Molecular Analysis of the Early Phases of the Regeneration Process in an Experimental Animal Model. PLoS One. 2014; 9(7): e102993. Published online 2014 Jul 23. doi: 10.1371/journal.pone.0102993
  • Paolo Borrione, Loredana Grasso, Elena Chierto, Stefano Geuna, Silvia Racca, Giuliana Abbadessa, Giulia Ronchi, Fabio Faiola, Alessia Di Gianfrancesco, Fabio Pigozzi, Experimental model for the study of the effects of plateletrich plasma on the early phases of muscle healing. Blood Transfus. 2014 Jan; 12(Suppl 1): s221–s228. doi: 10.2450/2013.027512
  • Borrione P, Grasso L, Racca S, Abbadessa G, Carriero V, Fagnani F, Quaranta F, Pigozzi F,Systemic effects of locally injected platelet rich plasma in a rat model: an analysis on muscle and bloodstream. J Biol Regul Homeost Agents. 2015 JanMar;29(1):2518.

Identification of molecular markers in the saliva of patients with oral and systemic inflammatory diseases

  • Baima G, Iaderosa G, Citterio F, Grossi S, Romano F, Berta GN, Buduneli N, Aimetti M. “Salivary metabolomics for the diagnosis of periodontal diseases: a systematic review with methodological quality assessment”. Metabolomics. 2021 Jan 1;17(1):1.
  • Citterio F, Romano F, Meoni G, Iaderosa G, Grossi S, Sobrero A, Dego F, Corana M, Berta GN, Tenori L, Aimetti M. “Changes in the Salivary Metabolic Profile of Generalized Periodontitis Patients after Non-surgical Periodontal Therapy: A Metabolomic Analysis Using Nuclear Magnetic Resonance Spectroscopy”. J Clin Med. 2020 Dec 8;9(12):3977.
  • Romano F, Del Buono W, Bianco L, Arena M, Mariani GM, Di Scipio F, Berta GN, Aimetti M. “Gingival Crevicular Fluid Cytokines in Moderate and Deep Sites of Stage III Periodontitis Patients in Different Rates of Clinical Progression”. Biomedicines. 2020 Nov 18;8(11):515.
  • Romano F, Castiblanco A, Spadotto F, Di Scipio F, Malandrino M, Berta GN, Aimetti M. “ICP-Mass-Spectrometry Ionic Profile of Whole Saliva in Patients with Untreated and Treated Periodontitis”. Biomedicines. 2020 Sep 15;8(9):354.
  • Romano F, Bongiovanni L, Bianco L, Di Scipio F, Yang Z, Sprio AE, Berta GN, Aimetti M. Clin Oral Investig. “Biomarker levels in gingival crevicular fluid of generalized aggressive periodontitis patients after non-surgical periodontal treatment”. 2018 Mar;22(2):1083-1092.

Mesenchymal stem cells derived from granulation tissue: potential therapeutic for periodontal regeneration

  • Olgasi C, Talmon M, Merlin S, Cucci A, Richaud-Patin Y, Ranaldo G, Colangelo D, Di Scipio F, Berta GN, Borsotti C, Valeri F, Faraldi F, Prat M, Messina M, Schinco P, Lombardo A, Raya A, Follenzi A. (2018). “Patient-Specific iPSC-Derived Endothelial Cells Provide Long-Term Phenotypic Correction of Hemophilia A”. Stem Cell Reports. 2018 Nov 3. pii: S2213-6711(18)30435-1. doi: 10.1016/j.stemcr.2018.10.012.
  • Di Scipio F, Sprio AE, Folino A, Carere ME, Salamone P, Yang Z, Berrone M, Prat M, Losano G, Rastaldo R, Berta GN. “Injured cardiomyocytes promote dental pulp mesenchymal stem cell homing”. Biochim Biophys Acta. 2014 Mar 12;1840(7):2152-2161. doi: 10.1016/j.bbagen.2014.03.005.
  • Zamperone A, Pietronave S, Merlin S, Colangelo D, Ranaldo G, Medico E, Di Scipio F, Berta GN, Follenzi A, Prat M. “Isolation and characterization of a spontaneously immortalized multipotent mesenchymal cell line derived from mouse subcutaneous adipose tissue”. Stem Cells Dev. 2013 Nov 1;22(21):2873-84. doi: 10.1089/scd.2012.0718.
  • Testa G, Gamba P, Di Scipio F, Sprio AE, Salamone P, Gargiulo S, Sottero B, Biasi F, Berta GN, Poli G, Leonarduzzi G. “Potentiation of amyloid-β peptide neurotoxicity in human dental-pulp neuron-like cells by the membrane lipid peroxidation product 4-hydroxynonenal”. Free Radic Biol Med. 2012 Sep 3;53(9):1708-1717. doi: 10.1016/j.freeradbiomed.2012.08.581.
  • Sprio AE, Di Scipio F, Raimondo S, Salamone P, Pagliari F, Pagliari S, Folino A, Forte G, Geuna S, Di Nardo P, Berta GN. “Self-Renewal and Multipotency Coexist in a Long-Term Cultured Adult Rat Dental Pulp Stem Cell Line: An Exception to the Rule?”. Stem Cells Dev. 2012 Jun 25. doi: 10.1089/scd.2012.0141.

Rheumatology

Pubblicazioni/Publications

  1. Novel and reliable DACTylitis glObal Sonographic (DACTOS) score in psoriatic arthritis. Zabotti A, Sakellariou G, Tinazzi I, Idolazzi L, Batticciotto A, Canzoni M, Carrara G, De Lucia O, Figus F, Girolimetto N, Macchioni P, McConnell R, Possemato N, Iagnocco A. Ann Rheum Dis. 2020;79:1037-43
  2. The predictive role of ultrasound-detected tenosynovitis and joint synovitis for flare in patients with rheumatoid arthritis in stable remission. Results of an Italian multicentre study of the Italian Society for Rheumatology Group for Ultrasound: the STARTER study. Filippou G, Sakellariou G, Scirè CA, Carrara G, Rumi F, Bellis E, Adinolfi A, Batticciotto A, Bortoluzzi A, Cagnotto G, Caprioli M, Canzoni M, Cavatorta FP, De Lucia O, Di Sabatino V, Draghessi A, Farina I, Focherini MC, Gabba A, Gutierrez M, Idolazzi L, Luccioli F, Macchioni Pi, Massarotti MS, Mastaglio C, Menza L, Muratore M, Parisi S, Picerno V, Piga M, Ramonda R, Raffeiner B, Rossi D, Rossi S, Rossini P, Scioscia C, Venditti C, Volpe A, Iagnocco A. Ann Rheum Dis 2018; 77:1283-89
  3. Identification of calcium pyrophosphate deposition disease (CPPD) by ultrasound: reliability of the OMERACT definitions in an extended set of joints-an international multiobserver study by the OMERACT Calcium Pyrophosphate Deposition Disease Ultrasound Subtask Force. Filippou G, Scirè CA, Adinolfi A, Damjanov NS, Carrara G, Bruyn GAW, Cazenave T, D'Agostino MA, Delle Sedie A, Di Sabatino V, Diaz Cortes ME, Filippucci E, Gandjbakhch F, Gutierrez M, Maccarter DK, Micu M, Möller Parera I, Mouterde G, Mortada MA, Naredo E, Pineda C, Porta F, Reginato AM, Satulu I,  Schmidt WA, Serban T, Terslev L, Vlad V, Vreju FA, Zufferey P, Bozios P, Toscano C, Picerno V, Iagnocco Ann Rheum Dis 2018; 77:1194-1199
  4. EULAR recommendations for the use of imaging in the clinical management of peripheral joint osteoarthritis. Sakellariou G, Conaghan PG, Zhang W,  Bijlsma JWJ, Boyesen P, D'Agostino MA, Doherty M, Fodor D,  Kloppenburg M, Miese F, Naredo E, Porcheret M, Iagnocco A. Ann Rheum Dis 2017;76:1484-94
  5. An OMERACT reliability exercise of inflammatory and structural abnormalities in patients with knee osteoarthritis using ultrasound assessment. AW Bruyn G, Naredo E, Damjanov N, Bachta A, Baudoin P, Hammer HB, Lamers-Karnebeek FBg, Moller Parera I, Richards B, Taylor M, Ben-Artzi A, D'Agostino MA, Garrido J, Iagnocco Ann Rheum Dis 2016; 75:842-6
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