IMMAGINE
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AGEs and Inflammation in Metabolic Disorders
Componenti
- Aragno Manuela (Coordinatore)
- Aimaretti Eleonora
Contatti
Attività
Research group
DSCB Unit of Experimental Medicine and Clinical Pathology
Manuela Aragno, PA
Giulia Usseglio Brancardo Thesis student
Research activity
Our research activity is been mainly focused on the role of advanced glycation end products (AGEs), oxidative stress and inflammation in the development of chronic diseases. AGEs are reactive metabolites deriving from exogenous sources or endogenous reactions between reducing sugars or fats and proteins. The tissue accumulation of AGEs is a hallmark of physiological ageing and is correlated to the gradual development of a low grade chronic inflammation, the so called “inflammaging” taking part in most of the age-related diseases. Recently we demonstrated that adult survivors of pediatric cancer which have been exposed to chemotherapy and radiotherapy in the youth display higher levels of plasma AGEs and AGEreceptors, as well as an altered plasma inflammatory and lipid profile that may be involved in the increased risk for early cardiovascular events extensively reported in cancer survivors.
We previously demonstrated in different models in animals models of diet-induced metabolic diseases that AGEs are critical drivers of alterations in many aspects of glucose and lipid metabolism, contributing, through direct and indirect mechanisms, to a general pro-inflammatory condition and energy metabolism impairment thanks to inter-organs crosstalk involving the gut, the liver, the kidney and the brain, thus suggesting their potential role in age-related morbidities, ranging from cardiovascular to neurodegenerative diseases.Another project in the starting phase thanks to a funding from the CRT 2022 Foundation
- HOdgkinLymphoma Disease survivors STUDY: AGE, inflammation and aging which received
a positive opinion from the ethics committee (00096/2023), relating to the evaluation
of oxidative stress, inflammaging and accumulation of AGEs and correlate them with the
presence of clinical and biochemical markers of premature aging, in a cohort of cancer
survivors treated for pediatric or young adult Hodgkin's lymphoma and compare them with
a control population consisting of age-matched subjects and one consisting of
adult-elderly subjects. Hodgkin's lymphoma was chosen for its number within the CAYACS
cohort currently in follow-up of the structures participating in the project, for the
high cumulative incidence of LE that characterizes these survivors and for the relative
homogeneity of the anticancer treatments used . Recently, the group has activated a collaboration with Prof. Ciocan
(Occupational medicine) in the evaluation of biological indicators of aging and
analysis of occupational parameters in a cohort of workers belonging to the
occupational medicine clinic with the relative approval of the Ethics Committee.
Study participants: eleonora Aimeretti and thesis student Atefeh Moradi.
The main object of our research is to evaluate molecular pathways affected by AGEs that are responsible for the onset of premature age-related diseases (i.e. epigenetic modifications of genes involved in pro-inflammatory/defensive pathways; mitochondrial dysfunction)
ATTIVITÀ DI RICERCA
La nostra attività di ricerca si è concentrata principalmente sul ruolo dei prodotti terminali della glicazione avanzata (AGE), dello stress ossidativo e dell'infiammazione nello sviluppo di malattie croniche. Gli AGE sono metaboliti reattivi derivanti da fonti esogene o reazioni endogene tra zuccheri riducenti o grassi e proteine. L'accumulo tissutale di AGE è un segno distintivo dell'invecchiamento fisiologico ed è correlato allo sviluppo graduale di un'infiammazione cronica di basso grado, la cosiddetta “meta infiammazione” che è presente nella maggior parte delle malattie legate all'età.
Recentemente abbiamo dimostrato che gli adulti sopravvissuti al linfoma di Hodgkin in età pediatrica che sono stati esposti a chemioterapia e radioterapia mostrano livelli più elevati di AGE plasmatici, nonché un profilo infiammatorio e lipidico plasmatico alterato che pu essere correlato all’'aumentato rischio cardiovascolare precoce ampiamente riportato nei sopravvissuti al linfoma. Abbiamo precedentemente dimostrato, in diversi modelli animali di malattie metaboliche indotte da dieta che gli AGE sono determinanti critici delle alterazioni del metabolismo del glucosio e dei lipidi, contribuendo, attraverso meccanismi diretti e indiretti, ad una condizione pro-infiammatoria sistemica e al deterioramento del metabolismo energetico grazie al cross-talk tra i vari organi, suggerendo così un loro potenziale ruolo nelle differenti morbilità legate all'età, che vanno dalle malattie cardiovascolari a quelle neurodegenerative. Altro progetto in fase di partenza grazie ad un finanziamento della Fondazione CRT 2022- HOdgkinLymphoma Disease survivors STUDY: AGE, inflammation and aging che ha avuto parere positivo dal comitato etico (00096/2023), relativo alla valutazione di stress ossidativo, inflammaging e l’accumulo di AGE e correlarli con la presenza di marcatori clinici e biochimici di aging prematuro, in una coorte di cancer survivors curati per linfoma di Hodgkin in età pediatrica o giovane adulta e confrontarli con una popolazione di controllo costituita da soggetti pari età ed una costituita da soggetti in età adulto-anziana. Il linfoma di Hodgkin è stato scelto per la sua numerosità all’interno della coorte di CAYACS attualmente in follow-up le strutture partecipanti al progetto, per l’elevata incidenza cumulativa di LE che caratterizza questi survivors e per la relativa omogeneità dei trattamenti antitumorali impiegati.
Recentemente il gruppo ha attivato una collaborazione con la Prof.ssa Ciocan (Medicina del lavoro) nella valutazione degli indicatori biologici di invecchiamento e analisi dei parametri lavorativi in una coorte di lavoratori afferenti all’ambulatorio di Medicina del Lavoro con relativa approvazione del Comitato etico. Partecipanti allo studio: eleonora Aimeretti e la tesista Atefeh Moradi.
L'obiettivo in tutti gli studi rimane quello di valutare il ruole chiave degli AGEs responsabili di scatenere l'insorgenza di prematura mallattie correlate con l'invecchiamento
Prodotti della ricerca
NEW VIRAL DISEASES AND NEW POSSIBLE REMEDIES THROUGH THE PHARMACOLOGY OF THE RENIN-
2023-01-01 Giovanni Sansoè; https://iris.unito.it/handle/2318/1919950
Anti-inflammatory and anti-glycative properties of zinc-enriched spirulina in diet-induced obese/diabetic mice
2022-01-01 Aimaretti E, Murzio C, Ferreira Alves G, Einaudi G, Collotta D, Porchietto E, Cifani C, Algeri A, Aragno M, Collino M, Mastrocola R https://iris.unito.it/handle/2318/1907200
Different impact of dietary fructose and galactose on metaflammation in rats: protective effects of prebiotic fructooligosaccharydes supplementation
2022-01-01 Mastrocola R, Collotta D, El-Masri F, Murzio C, Aimaretti E, Aragno M, Frank J, Collino M https://iris.unito.it/handle/2318/1907211
ICOS-Fc as innovative immunomodulatory approach to counteract inflammation and organ injury in sepsis
2022-01-01 Alves, Gustavo Ferreira; Stoppa, Ian; Aimaretti, Eleonora; Monge, Chiara; Mastrocola, Raffaella; Porchietto, Elisa; Einaudi, Giacomo; Collotta, Debora; Bertocchi, Ilaria; Boggio, Elena; Gigliotti, Casimiro Luca; Clemente, Nausicaa; Aragno, Manuela; Fernandes, Daniel; Cifani, Carlo; Thiemermann, Christoph; Dianzani, Chiara; Dianzani, Umberto; Collino, Massimo https://iris.unito.it/handle/2318/1876525
Aging, sex and NLRP3 inflammasome in cardiac ischaemic disease
2022-01-01 Alloatti, Giuseppe; Penna, Claudia; Comità, Stefano; Tullio, Francesca; Aragno, Manuela; Biasi, Fiorella; Pagliaro, Pasquale https://iris.unito.it/handle/2318/1881406
Pharmacological Inhibition of FAK-Pyk2 Pathway Protects Against Organ Damage and Prolongs the Survival of Septic Mice
2022-01-01 Alves G.F.; Aimaretti E.; Einaudi G.; Mastrocola R.; de Oliveira J.G.; Collotta D.; Porchietto E.; Aragno M.; Cifani C.; Sordi R.; Thiemermann C.; Fernandes D.; Collino M. https://iris.unito.it/handle/2318/1856357
Advanced glycation end products and their related signaling cascades in adult survivors of childhood Hodgkin lymphoma: A possible role in the onset of late complications
2022-01-01 Felicetti F.; Aimaretti E.; Dal Bello F.; Gatti F.; Godono A.; Saba F.; Einaudi G.; Collino M.; Fagioli F.; Aragno M.; Brignardello E. https://iris.unito.it/handle/2318/1856356
The mitochondrial trigger in an animal model of nonalcoholic fatty liver disease
2021-01-01 Guglielmina Chimienti; Antonella Orlando; Francesco Russo; Benedetta D’Attoma; Manuela Aragno; Eleonora Aimaretti ; Angela Maria Serena Lezza; Vito Pesce https://iris.unito.it/handle/2318/1861221
Altered hepatic sphingolipid metabolism in insulin resistant mice: Role of advanced glycation endproducts
2021-01-01 Mastrocola R.; Dal Bello F.; Cento A.S.; Gaens K.; Collotta D.; Aragno M.; Medana C.; Collino M.; Wouters K.; Schalkwijk C.G. https://iris.unito.it/handle/2318/1789498
Deletion of RAGE fails to prevent hepatosteatosis in obese mice due to impairment of other AGEs receptors and detoxifying systems
2021-01-01 Wouters K.; Cento A.S.; Gaens K.H.; Teunissen M.; Scheijen J.L.J.M.; Barutta F.; Chiazza F.; Collotta D.; Aragno M.; Gruden G.; Collino M.; Schalkwijk C.G.; Mastrocola R. https://iris.unito.it/handle/2318/1802050
COVID-19 and Liver Cirrhosis: Focus on the Nonclassical Renin-Angiotensin System and Implications for Therapy
2021-01-01 Sansoe G.; Aragno M.; Wong F. https://iris.unito.it/handle/2318/1844042
Baricitinib counteracts metaflammation protecting against diet-induced metabolic abnormalities in mice
2020-01-01 Collotta D, Hull W, Mastrocola R, Chiazza F, Cento AS, Murphy C, Verta R, Ferreira Alves G, Gaudioso G, Fava F, Aragno M, Tuohy K, Thiemermann C, Collino M https://iris.unito.it/handle/2318/1789502
Diabetic Cardiomyopathy and Ischemic Heart Disease: Prevention and Therapy by Exercise and Conditioning
2020-01-01 Crisafulli, Antonio; Pagliaro, Pasquale; Roberto, Silvana; Cugusi, Lucia; Mercuro, Giuseppe; Lazou, Antigone; Beauloye, Christophe; Bertrand, Luc; Hausenloy, Derek J; Aragno, Manuela; Penna, Claudia https://iris.unito.it/handle/2318/1737773
Baricitinib counteracts metaflammation, thus protecting against diet-induced metabolic abnormalities in mice
2020-01-01 Collotta D.; Hull W.; Mastrocola R.; Chiazza F.; Cento A.S.; Murphy C.; Verta R.; Alves G.F.; Gaudioso G.; Fava F.; Yaqoob M.; Aragno M.; Tuohy K.; Thiemermann C.; Collino M. https://iris.unito.it/handle/2318/1758975
Effect of hyperglycaemia and diabetes on acute myocardial ischaemia–reperfusion injury and cardioprotection by ischaemic conditioning protocols
2020-01-01 Penna C.; Andreadou I.; Aragno M.; Beauloye C.; Bertrand L.; Lazou A.; Falcao-Pires I.; Bell R.; Zuurbier C.J.; Pagliaro P.; Hausenloy D.J. https://iris.unito.it/handle/2318/1737775
Pathway of hepatic and renal damage through non-classical activation of the renin-angiotensin system in chronic liver disease
2020-01-01 Giovanni Sansoè ; Manuela Aragno ; Florence Wong https://iris.unito.it/handle/2318/1793794
Role of temperature in myocardial ischemic injury and protection by conditioning
2020-01-01 Pasquale Pagliaro, Manuela Aragno, Claudia Penna https://iris.unito.it/handle/2318/1737774
Do P2Y12 receptor antagonism and NLRP3 inhibition exert additive cardioprotective effects against ischemia/reperfusion injury?
2020-01-01 Elisa Zicola, Saveria Femminò, Fausto Chiazza, Debora Collotta, Massimo Collino, Manuela Aragno, Massimo Bertinaria, Pasquale https://iris.unito.it/handle/2318/1872839
Effects of exogenous dietary advanced glycation end products on the cross-talk mechanisms linking microbiota to metabolic inflammation
2020-01-01 Mastrocola R.; Collotta D.; Gaudioso G.; Le Berre M.; Cento A.S.; Ferreira G.A.; Chiazza F.; Verta R.; Bertocchi I.; Manig F.; Hellwig M.; Fava F.; Cifani C.; Aragno M.; Henle T.; Joshi L.; Tuohy K.; Collino M. https://iris.unito.it/handle/2318/1758979
Advanced glycation end products and chronic inflammation in adult survivors of childhood leukemia treated with hematopoietic stem cell transplantation
2020-01-01 Francesco Felicetti, Alessia Sofia Cento, Paolo Fornengo, Maurizio Cassader, Raffaella Mastrocola, Fabrizio D’Ascenzo, Fabio Settanni, Andrea Benso, Emanuela Arvat, Massimo Collino, Franca Fagioli, Manuela Aragno, Enrico Brignardello https://iris.unito.it/handle/2318/1725722
Ticagrelor Conditioning Effects Are Not Additive to Cardioprotection Induced by Direct NLRP3 Inflammasome Inhibition: Role of RISK, NLRP3, and Redox Cascades
2020-01-01 Penna, Claudia; Aragno, Manuela; Cento, Alessia Sofia; Femminò, Saveria; Russo, Isabella; Bello, Federica Dal; Chiazza, Fausto; Collotta, Debora; Alves, Gustavo Ferreira; Bertinaria, Massimo; Zicola, Elisa; Mercurio, Valentina; Medana, Claudio; Collino, Massimo; Pagliaro, Pasquale https://iris.unito.it/handle/2318/1748513
Dietary advanced glycation endproducts in the mechanisms linking proteins glycosylation pattern, microbiota, and metabolic inflammation
2020-01-01 Mastrocola R, Collotta D, Manig F, Verta R, Le Berre M, Fava F, Gaudioso G, Aragno M, Chiazza F, Hellwig M, Gerlach JQ, Tuohy KM, Joshi L, Henle T, Collino M https://iris.unito.it/handle/2318/1789501
Do P2Y12 receptor antagonism and NLRP3 inhibition exert additive cardioprotective effects against ischemia/reperfusion injury?
2019-01-01 Fausto Chiazza, Saveria Femminò, Debora Collotta, Elisa Zicola, Manuela Aragno, Massimo Bertinaria, Pasquale Pagliaro, Claudia Penna, Massimo Collino https://iris.unito.it/handle/2318/1755511
Inhibition of AGEs by pyridoxamine prevents diet-induced systemic inflammation and skeletal muscle insulin resistance by restoring SphK/S1P3/RhoA signalling
2019-01-01 Cento, AS; Collotta, D; Chiazza, F; Aragno, M; Collino, M; Mastrocola, R https://iris.unito.it/handle/2318/1740402
Identification of Annexina1 as an endogenous regulator of RhoA, and its role in the pathophysiology and experimental therapy of type-2 diabetes
2019-01-01 Purvis G.S.D.; Collino M.; Loiola R.A.; Baragetti A.; Chiazza F.; Brovelli M.; Sheikh M.H.; Collotta D.; Cento A.; Mastrocola R.; Aragno M.; Cutrin J.C.; Reutelingsperger C.; Grigore L.; Catapano A.L.; Yaqoob M.M.; Norata G.D.; Solito E.; Thiemermann C. https://iris.unito.it/handle/2318/1723107
SALIVAGE – EU JPI Project
2018-01-01 Liberto E, Cordero C, Mastrocola R, Ferrocino I, Chiazza F, Cento AS, Collotta D, Rantsiou K, https://iris.unito.it/handle/2318/1678782
Genetic deletion of RAGE in Dbdb mice interferes with AGEs receptors and detoxifying systems in liver
2018-01-01 Cento Alessia; https://iris.unito.it/handle/2318/1889881
IMPAIRED SECRETION OF RENALASE INTO BLOOD MAY LEAD TO SYMPATHETIC OVERACTIVITY AND EARLY SODIUM RETENTION IN EXPERIMENTAL LIVER CIRRHOSIS
2018-01-01 Sansoe, G; Aragno, M; Mastrocola, R; Parola, M https://iris.unito.it/handle/2318/1708360
Reduced Susceptibility to Sugar-Induced Metabolic Derangements and Impairments of Myocardial Redox Signaling in Mice Chronically Fed with D-Tagatose when Compared to Fructose
2018-01-01 Collotta, Debora; Lucarini, Laura; Chiazza, Fausto; Cento, Alessia Sofia; Durante, Mariaconcetta; Sgambellone, Silvia; Chini, Jacopo; Baratta, Francesca; Aragno, Manuela; Mastrocola, Raffaella; Masini, Emanuela; Collino, Massimo https://iris.unito.it/handle/2318/1683457
Fructose liquid and solid formulations differently affect gut integrity, microbiota composition and related liver toxicity: a comparative in vivo study
2018-01-01 Mastrocola, Raffaella; Ferrocino, Ilario; Liberto, Erica; Chiazza, Fausto; Cento, Alessia Sofia; Collotta, Debora; Querio, Giulia; Nigro, Debora; Bitonto, Valeria; Cutrin, Juan Carlos; Rantsiou, Kalliopi; Durante, Mariaconcetta; Masini, Emanuela; Aragno, Manuela; Cordero, Chiara; Cocolin, Luca; Collino, Massimo https://iris.unito.it/handle/2318/1661849
Metaflammation: tissue-specific alterations of the NLRP3 inflammasome platform
2018-01-01 Mastrocola, Raffaella; Aragno, Manuela; Alloatti, Giuseppe; Collino, Massimo; Penna, Claudia; Pagliaro, Pasquale https://iris.unito.it/handle/2318/1634181
TISSUE RENIN-ANGIOTENSIN SYSTEM IN THE KIDNEY OF ASCITIC CIRRHOSIS: AN INNOCENT BYSTANDER OR A PROTAGONIST?
2018-01-01 Sansoe, G; Aragno, M; Mastrocola, R; Parola, M https://iris.unito.it/handle/2318/1708364
IN EXPERIMENTAL ASCITIC CIRRHOSIS REDUCTION OF ADRENERGIC FUNCTION HAS CONSIDERABLE AQUARETIC EFFECTS: PATHOPHYSIOLOGICAL AND CLINICAL CONSEQUENCES
2018-01-01 Sansoe, G; Aragno, M; Mastrocola, R; Parola, M https://iris.unito.it/handle/2318/1708363
AGEs induce alterations of sphingolipids metabolism in the liver of genetically- and diet-induced diabetic mice
2018-01-01 Cento, AS; Gaens, K; Collotta, D; Chiazza, F; Barutta, F; Scheijen, J; Aragno, M; Collino, M; Wouters, K; Schalkwijk, CG; Mastrocola, R https://iris.unito.it/handle/2318/1740097
Stable Oxidative Cytosine Modifications Accumulate in Cardiac Mesenchymal Cells from Type2 Diabetes Patients: Rescue by alpha Ketoglutarate and TET-TDG Functional Reactivation
2018-01-01 Spallotta, Francesco; Cencioni, Chiara; Atlante, Sandra; Garella, Davide; Cocco, Mattia; Mori, Mattia; Mastrocola, Raffaella; Kuenne, Carsten; Guenther, Stefan; Nanni, Simona; Azzimato, Valerio; Zukunft, Sven; Kornberger, Angela; Sã¼rã¼n, Duran; Schnã¼tgen, Frank; Von Melchner, Harald; Di Stilo, Antonella; Aragno, Manuela; Braspenning, Maarten; Van Criekinge, Wim; De Blasio, Miles J.; Ritchie, Rebecca H.; Zaccagnini, Germana; Martelli, Fabio; Farsetti, Antonella; Fleming, Ingrid; Braun, Thomas; Beiras-Fernandez, Andres; Botta, Bruno; Collino, Massimo; Bertinaria, Massimo; Zeiher, Andreas M.; Gaetano, Carlo https://iris.unito.it/handle/2318/1657432
Genetic deletion of RAGE in db/db mice interferes in the liver with other AGE-receptors and AGE-detoxifying systems sustaining lipogenesis and inflammation
2018-01-01 Mastrocola, R; Cento, AS; Collotta, D; Chiazza, F; Barutta, F; Scheijen, J; Aragno, M; Gaens, K; Collino, M; Schalkwijk, CG; Wouters, K https://iris.unito.it/handle/2318/1740098
Effects of Vitamin D on insulin resistance and myosteatosis in diet-induced obese mice
2018-01-01 Benetti, Elisa*; Mastrocola, Raffaella; Chiazza, Fausto; Nigro, Debora; D’Antona, Giuseppe; Bordano, null; Fantozzi, Roberto; Aragno, Manuela; Collino, Massimo; Minetto, Marco Alessandro https://iris.unito.it/handle/2318/1660078
Toxicological impact of high fructose intake on gut microbiota and liver/intestine integrity: Any differences between solid and liquid formulations?
2017-01-01 Mastrocola, R; Cento, As; Chiazza, F; Ferrocino, I; Bitonto, V; Nigro, D; Querio, G; Rantsiou, K; Cutrin, Jc; Aragno, M; Liberto, E; Masini, E; Cordero, C; Cocolin, L; Collino, M. https://iris.unito.it/handle/2318/1657437
Local renin–angiotensin system in the kidney of ascitic cirrhosis: An innocent bystander or a major protagonist?
2017-01-01 Sansoè, G.; Aragno, M.; Mastrocola, R.; Ayoubi, M.; Parola, M. https://iris.unito.it/handle/2318/1708368
Dietary sugars and endogenous formation of advanced glycation endproducts: Emerging mechanisms of disease
2017-01-01 Aragno, Manuela; Mastrocola, Raffaella https://iris.unito.it/handle/2318/1641649
In experimental liver cirrhosis impaired secretion of renalase into blood may lead to organ damage and sympathetic overactivity
2017-01-01 Sansoè, G.; Aragno, M.; Mastrocola, R.; Ayoubi, M.; Parola, M. https://iris.unito.it/handle/2318/1708371
Protective Effects of Pyridoxamine Supplementation in the Early Stages of Diet-Induced Kidney Dysfunction
2017-01-01 Chiazza, F; Cento, A. S; Collotta, D; Nigro, D; Rosa, G; Baratta, F; Bitonto, V; Cutrin, J. C; Aragno, M; Mastrocola, R; Collino, M. https://iris.unito.it/handle/2318/1657424
In experimental ascitic cirrhosis reduction of adrenergic function by means of α2A adrenergic receptor agonists has considerable aquaretic effects
2017-01-01 Sansoè, G.; Aragno, M.; Mastrocola, R.; Ayoubi, M.; Parola, M. https://iris.unito.it/handle/2318/1708372
Effects of chronic sugar consumption on lipid accumulation and autophagy in the skeletal muscle
2017-01-01 de Stefanis, Daniela; Mastrocola, Raffaella; Nigro, Debora; Costelli, Paola; Aragno, Manuela https://iris.unito.it/handle/2318/1528854
Considerable aquaretic effects in experimental ascitic cirrhosis achieved through blunting of adrenergic function with α2A adrenergic receptor agonists
2017-01-01 Sansoe’, G.; Aragno, M.; Mastrocola, R.; Ayoubi, M.; Parola, M. https://iris.unito.it/handle/2318/1708377
Chronic administration of saturated fats and fructose differently affect SREBP activity resulting in different modulation of Nrf2 and Nlrp3 inflammasome pathways in mice liver
2017-01-01 Nigro, Debora; Menotti, Francesca; Cento, Alessia S; Serpe, Loredana; Chiazza, Fausto; Dal Bello, Federica; Romaniello, Francesco; Medana, Claudio; Collino, Massimo; Aragno, Manuela; Mastrocola, Raffaella https://iris.unito.it/handle/2318/1624845
The AGEs inhibitor pyridoxamine prevents kidney injury and dysfunction in mice fed high-fat high-fructose diet
2017-01-01 Collino, M; Chiazza, F; Collotta, D; Cento, As; Nigro, D; Bitonto, V; Cutrin, Jc; Aragno, M; Mastrocola, R. https://iris.unito.it/handle/2318/1657438
Advanced Glycation End Products Inhibition Restores Sphingolipid Rheostat in Mice Liver and Prevents Diet-Induced Insulin Resistance
2016-01-01 Cento, Alessia Sofia; Nigro, Debora; Chiazza, Fausto; Dal Bello, Federica; Romaniello, Francesco; Collino, Massimo; Medana, Claudio; Aragno, Manuela; Mastrocola, Raffaella https://iris.unito.it/handle/2318/1630474
Cardiac Epi-Metabolic Signature Revealed by Integrated Omics Approach in Diabetic Patients: Rescue by Active DNA Demethylation via TET-TDG Complex Reactivation
2016-01-01 Spallotta, F; Cencioni, C; Atlante, S; Garella, D; Cocco, M; Mori, M; Mastrocola, R; Kuenne, C; Guenther, S; Nanni, S; Azzimato, V; Zukunft, S; Kornberger, A; Di Stilo, A; Aragno, M; Martelli, F; Farsetti, A; Fleming, I; Braun, T; Beiras-Fernandez, A; Botta, B; Collino, M; Bertinaria, M; Zeiher, Am; Gaetano, C. https://iris.unito.it/handle/2318/1657445
Pathogenesis of Solute-Free Water Retention in Experimental Ascitic Cirrhosis: Is Vasopressin the Only Culprit?
2016-01-01 Sansoe', Giovanni; Aragno, Manuela; Mastrocola, Raffaella; Parola, Maurizio https://iris.unito.it/handle/2318/1528853
Alpha-2A Adrenoceptor Agonist Guanfacine Restores Diuretic Efficiency in Experimental Cirrhotic Ascites: Comparison with Clonidine
2016-01-01 Sansoè, Giovanni; Aragno, Manuela; Mastrocola, Raffaella; Mengozzi, Giulio; Parola, Maurizio https://iris.unito.it/handle/2318/1585320
Maladaptive Modulations of NLRP3 Inflammasome and Cardioprotective Pathways Are Involved in Diet-Induced Exacerbation of Myocardial Ischemia/Reperfusion Injury in Mice
2016-01-01 Mastrocola, Raffaella; Collino, Massimo; Penna, Claudia; Nigro, Debora; Chiazza, Fausto; Fracasso, Veronica; Tullio, Francesca; Alloatti, Giuseppe; Pagliaro, Pasquale; Aragno, Manuela https://iris.unito.it/handle/2318/1545358
Role of Chymase in the Development of Liver Cirrhosis and Its Complications: Experimental and Human Data
2016-01-01 Sansoè, Giovanni; Aragno, Manuela; Mastrocola, Raffaella; Mengozzi, Giulio; Novo, Erica; Parola, Maurizio https://iris.unito.it/handle/2318/1598612
Fructose-derived advanced glycation end-products drive lipogenesis and skeletal muscle reprogramming via SREBP-1c dysregulation in mice
2016-01-01 Mastrocola, R; Nigro, D; Chiazza, F; Medana, C; Dal Bello, F; Boccuzzi, G; Collino, M; Aragno, M https://iris.unito.it/handle/2318/1542011
Pharmacological inhibition of NLRP3 inflammasome attenuates myocardial ischemia/reperfusion injury by activation of RISK and mitochondrial pathways
2016-01-01 Mastrocola, Raffaella; Penna, Claudia; Tullio, Francesca; Femminò, Saveria; Nigro, Debora; Chiazza, Fausto; Serpe, Loredana; Collotta, Debora; Alloatti, Giuseppe; Cocco, Mattia; Bertinaria, Massimo; Pagliaro, Pasquale; Aragno, Manuela; Collino, Massimo https://iris.unito.it/handle/2318/1624808
Dose-dependecy of clonidine's effects in ascitic cirrhotic rats: Comparison with α1-adrenergic agonist midodrine.
2016-01-01 Sansoè, G; Aragno, M; Mastrocola, R; Parola, M2. https://iris.unito.it/handle/2318/1521213
High-fructose intake as risk factor for neurodegeneration: Key role for carboxy methyllysine accumulation in mice hippocampal neurons
2016-01-01 Mastrocola, Raffaella; Nigro, Debora; Cento, Alessia S; Chiazza, Fausto; Collino, Massimo; Aragno, Manuela https://iris.unito.it/handle/2318/1554565
Pyridoxamine prevents diet-induced insulin resistance through the regulation of ceramide/sphingosine/sphingosine-1-phosphate equilibrium in mice liver
2016-01-01 Mastrocola, R; Nigro, D; Cento, As; Schiano, G; Chiazza, F; Dal Bello, F; Romaniello, F; Collino, M; Medana, C; Aragno, M. https://iris.unito.it/handle/2318/1625266
Fructose-derived advanced glycation end-products induce a negative crosstalk between lipogenesis and muscle reprogramming in mice through SREBP-1c
2015-01-01 Mastrocola R; Collino M; Nigro D; Medana C; Dal Bello F; Chiazza F; Boccuzzi G; Aragno M. https://iris.unito.it/handle/2318/1525579
Targeting the NLRP3 inflammasome to reduce diet-induced metabolic abnormalities in mice
2015-01-01 Chiazza, Fausto; Couturier-Maillard, Aurélie; Benetti, Elisa; Mastrocola, Raffaella; Nigro, Debora; Cutrin, Juan C; Serpe, Loredana; Aragno, Manuela; Fantozzi, Roberto; Ryffel, Bernard; Thiemermann, Christoph; Collino, Massimo https://iris.unito.it/handle/2318/1550762
Accumulation of Advanced Glycation End-Products and Activation of the SCAP/SREBP Lipogenetic Pathway Occur in Diet-Induced Obese Mouse Skeletal Muscle.
2015-01-01 Mastrocola R; Collino M; Nigro D; Chiazza F; D'Antona G; Aragno M; Minetto MA https://iris.unito.it/handle/2318/157075
Is NLRP3 inflammasome a new pharmacological target in myocardial ischemia/reperfusion injury?
2015-01-01 Femminò, S; Chiazza, F; Mastrocola, R; Tullio, F; Penna, C; Nigro, D; Alloatti, G; Cocco, M; Garella, D; Bertinaria, M; Fantozzi, R; Aragno, M; Collino, M; Pagliaro, P https://iris.unito.it/handle/2318/1563302
Exacerbation of myocardial ischemia/reperfusion injury induced by high-fat-high-fructose (HFHF) diet: Role of NLRP3 inflammasome
2015-01-01 Tullio, F.; Chiazza, F.; Mastrocola, R.; Penna, C.; Nigro, D.; Fracasso, V.; Alloatti, G.; Fantozzi, R.; Aragno, M.; Collino, M.; Pagliaro, P. https://iris.unito.it/handle/2318/1563309
A non-erythropoietic peptide derivative of erythropoietin decreases susceptibility to diet-induced insulin resistance in mice
2014-01-01 M Collino;E Benetti;M Rogazzo;F Chiazza;R Mastrocola;D Nigro;J C Cutrin;M Aragno;R Fantozzi;M A Minetto;C Thiemermann https://iris.unito.it/handle/2318/154526
Variability in myosteatosis and insulin resistance induced by high-fat diet in mouse skeletal muscles.
2014-01-01 Collino M;Mastrocola R;Nigro D;Chiazza F;Aragno M;D'Antona G;Minetto MA https://iris.unito.it/handle/2318/149879
Fructose-Derived Advanced Glycation End-Products Evoke Skeletal Muscle Damage in Mice by Multiple Interference with SCAP-SREBP Pathway
2014-01-01 Raffaella Mastrocola;Debora Nigro;Fausto Chiazza;Massimo Collino;Manuela Aragno https://iris.unito.it/handle/2318/150148
A LIPIDOMIC STUDY OF HIGH-FAT DIET TREATED MICE.
2014-01-01 Federica Dal Bello; Valentina Santoro; Manuela Aragno; Raffaella Mastrocola; Claudio Medana; Claudio Baiocchi. https://iris.unito.it/handle/2318/153711
Dynamics of sodium retention in preascitic cirrhotic rats assessed through parathyroid hormone injection.
2014-01-01 Sansoe G;Mastrocola R;Aragno M;Parola M https://iris.unito.it/handle/2318/150150
Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR- agonism correlates with impaired NLRP3 inflammasome activation
2013-01-01 Massimo Collino; Elisa Benetti; Mara Rogazzo; Raffaella Mastrocola; Muhammed M. Yaqoob; Manuela Aragno; Christoph Thiemermann; Roberto Fantozzi https://iris.unito.it/handle/2318/119475
A nonerythropoietic peptide analog of erythropoietin decreases susceptibility to diet-induced insulin resistance
2013-01-01 E. Benetti; M. Collino; M. Rogazzo; F. Chiazza; R. Mastrocola; M. Aragno; M. Minetto; C. Thiemermann; R. Fantozzi https://iris.unito.it/handle/2318/144592
Inflammatory signaling and insulin resistance caused by sugar intake: modulation by PPAR-δ agonism
2013-01-01 M. Rogazzo; M. Collino; E. Benetti; F. Chiazza; R. Mastrocola; M. Minetto; M. Aragno; C. Thiemermann; R. Fantozzi. https://iris.unito.it/handle/2318/144597
Multiple courses of G-CSF in patients with decompensated cirrosi: consistent mobilization of immature cells ex pressing hepatocyte markers and exploratory clinical evaluation.
2013-01-01 Gaia S; Olivero A; Smedile A; Ruella M; Abate ML; Fadda M; Rolle E; Omdé P; Bondesan P; Passera r; Risso A; Aragno M; Marzano A; Ciancio A; Rizzetto M; Tarella C. https://iris.unito.it/handle/2318/154133
Calcium receptors located in fibrotic septa: a new target to reduce portal pressure in liver cirrhosis
2013-01-01 Giovanni Sansoè;Manuela Aragno;Raffaella Mastrocola;Claudia Paternostro;Maurizio Parola https://iris.unito.it/handle/2318/130145
High Sugar Intake and Development of Skeletal Muscle Insulin Resistance and Inflammation in Mice: A Protective Role for PPAR- δ Agonism.
2013-01-01 Benetti E;Mastrocola R;Rogazzo M;Chiazza F;Aragno M;Fantozzi R;Collino M;Minetto MA https://iris.unito.it/handle/2318/138588
Advanced glycation end-products promote hepatosteatosis by interfering with SCAP-SREBP pathway in fructose drinking mice
2013-01-01 Mastrocola R; Collino M; Rogazzo M; Medana C; Nigro D; Boccuzzi G; Aragno M. https://iris.unito.it/handle/2318/138695
Study of the photocatalytic transformation of synephrine: a biogenic amine relevant in anti-doping analysis
2013-01-01 C.Medana;P. Calza;V. Giancotti;F. Dal Bello;M. Aragno;C. Baiocchi https://iris.unito.it/handle/2318/141890
Inhibition of chymase-dependent production of kidney angiotensin II improves renal sodium handling and prevents ascites in experimental liver cirrhosis
2012-01-01 Sansoè G; Aragno M; Mastrocola R; Mengozzi G; Novo E; Smedile A; Parola M; Rizzetto M. https://iris.unito.it/handle/2318/99931
Key role of chymase in the hepatic production of angiotensin II and in the development of experimental liver cirrhosis and its complications.
2012-01-01 Sansoè G; Aragno M; Mastrocola R; Mengozzi G; Paternostro C; Smedile A; Rizzetto M; Parola M. https://iris.unito.it/handle/2318/99930
Obestatin induced recovery of myocardial dysfunction in type 1 diabetic rats: underlying mechanisms.
2012-01-01 Aragno M; Mastrocola R; Ghé C; Arnoletti E; Bassino E; Alloatti G; Muccioli G. https://iris.unito.it/handle/2318/125766
Advanced Glycation End-Products Promote Lipogenesis in Liver of Fructose-Drinking Mice
2012-01-01 Mastrocola R; Collino M; Nigro D; Medana C; Aragno M. https://iris.unito.it/handle/2318/127265
Key role of chymase in the hepatic production of angiotensin II and in the development of experimental liver cirrhosis and its complications.
2012-01-01 Sansoè G; Aragno M; Mastrocola R; Mengozzi G; Paternostro C; Smedile A; Rizzetto M; Parola M. https://iris.unito.it/handle/2318/101458
Inhibition of chymase-dependent production of kidney angiotensin II improves renal sodium handling and prevents ascites in experimental liver cirrhosis
2012-01-01 Sansoè G; Aragno M; Mastrocola R; Mengozzi G; Novo E; Smedile A; Parola M; Rizzetto M. https://iris.unito.it/handle/2318/99720
High-fructose corn syrup (HFCS) diet induces an NLRP-3 inflammasome-mediated response in the kidney: protection by PPARb/d agonist
2012-01-01 E. Benetti; M. Collino; M. Rogazzo; M. Aragno; R. Mastrocola; R. Fantozzi https://iris.unito.it/handle/2318/121570
Effect of n-3 fatty acids on patients with advanced lung cancer: a double-blind, placebo-controlled study.
2012-01-01 Finocchiaro C;Segre O;Fadda M;Monge T;Scigliano M;Schena M;Tinivella M;Tiozzo E;Catalano MG;Pugliese M;Fortunati N;Aragno M;Muzio G;Maggiora M;Oraldi M;Canuto RA https://iris.unito.it/handle/2318/131008
AGEs/RAGE complex upregulates BACE1 via NF-kappaB pathway activation
2012-01-01 Guglielmotto M; Aragno M; Tamagno E; Vercellinatto I; Visentin S; Medana C; Catalano MG; Smith MA; Perry G; Danni O; Boccuzzi G; Tabaton M. https://iris.unito.it/handle/2318/81738
Dysregulation of SREBP2 induces BACE1 expression.
2011-01-01 R. Mastrocola;M. Guglielmotto;C. Medana;M. G. Catalano;S. Cutrupi;R. Borghi;E. Tamagno;G. Boccuzzi;M. Aragno https://iris.unito.it/handle/2318/154655
Advanced glycation end products (AGEs) as pathology biomarkers: microwave assisted synthesis and biological quantitative analysis by LC-FTMS
2011-01-01 C. Medana; S. Visentin; F. Dal Bello; V. Giancotti; R. Mastrocola ; M. Aragno; C. Baiocchi https://iris.unito.it/handle/2318/99837
Peroxisome proliferator-activated receptor β/δ agonism protects the kidney against ischemia/reperfusion injury in diabetic rats.
2011-01-01 Collino M; Benetti E; Miglio G; Castiglia S; Rosa AC; Aragno M; Thiemermann C; Fantozzi R. https://iris.unito.it/handle/2318/81551
Pioglitazone improves lipid and insulin levels in overweight rats on a high cholesterol and fructose diet by decreasing hepatic inflammation.
2010-01-01 Collino M; Aragno M; Castiglia S; Miglio G; Tomasinelli C; Boccuzzi G; Thiemermann C; Fantozzi R. https://iris.unito.it/handle/2318/99870
Liver cirrhosis and intrahepatic rennin-angiotensin system: a reappraisal.
2010-01-01 Sansoé G; Aragno M; Tomasinelli CE; Mastrocola R; Parola M https://iris.unito.it/handle/2318/84275
Receptors of calcium and calcimimetic agents inside the cirrotic liver are new targets to reduce portal pressure.
2010-01-01 Sansoè G;Aragno M; Tommasinelli C.E; Parola M. https://iris.unito.it/handle/2318/83052
Free-water retention occurs in experimental preascitic liver cirrosi and is influenced by extracellular calcium.
2010-01-01 Sansoé G; Aragno M; Mastrocola R; Parola M https://iris.unito.it/handle/2318/84274
Hypercholesterolemia and Risk of Alzheimer's Disease: a New Role for the Cholesterogenic Factor SREBP2
2010-01-01 Mastrocola R; Guglielmotto M; Tamagno E; Danni O; Aragno M. https://iris.unito.it/handle/2318/87696
AGEs up-regulates BACE1 through their interaction with RAGE and NFkB activation.
2010-01-01 Guglielmotto M; Mastrocola R; Aragno M; Tamagno E; Danni O; Boccuzzi G; Tabaton M. https://iris.unito.it/handle/2318/87697
Thiamine protects the kidney against the injury and dysfunction caused by ischaemia reperfusion by multiple mechanisms
2010-01-01 Memon S; Kieswich J; Allen D; James A; Patel N; Raftery M; Thiemermann C; Yaqoob M; Collino M; Aragno M; Fantozzi R; Castiglia S; Cuzzocrea S; Mazzon E https://iris.unito.it/handle/2318/127596
Biomolecular expression of target receptors of calcimimetic agents in experimental liver cirrhosis: a new strategy to reduce portal pressure.
2010-01-01 Sansoè G; Aragno M; Tomasinelli C; Valfrè di Bonzo L; Parola M; Smedile A; Rizzetto M. https://iris.unito.it/handle/2318/75983
Identification of the Henle’s loop as a major site of sodium retention in experimental pre-ascitic cirrhosis: effects of parathyroid hormone
2010-01-01 Sansoè G; Aragno M; Novo E; Mastrocola R; Parola M. https://iris.unito.it/handle/2318/75910
Intrahepatic renin-angiotensin system and liver cirrhosis: an updated reappraisal.
2010-01-01 Sansoè G; Aragno M; Tomasinelli C; Mastrocola R; Parola M. https://iris.unito.it/handle/2318/75984
Calcium-dependent diuretic system in preascitic liver cirrhosis.
2010-01-01 Sansoè G; Aragno M; Tomasinelli CE; di Bonzo LV; Wong F; Parola M. https://iris.unito.it/handle/2318/129813
Mitochondrial DNA copy number and citrate synthase activity in nonalcoholic fatty liver disease induced in rats by a high-fat plus fructose diet fortified or not with dehydroepiandrosterone (DHEA)
2009-01-01 Lezza AMS; Cassano P; Mastrocola R; Pesce V; Aragno M; Gadaleta MN https://iris.unito.it/handle/2318/1625596